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US20120322066 Development of Novel Detergents for Use in PCR Systems  
This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (PCR). Methods for...
US20120245173 INHIBITION OF ACTIVATED CDC42-ASSOCIATED KINASE 1  
Compounds, compositions, and methods for specific inhibition of activated cdc42-associated kinase 1 (Ack1) are provided.
US20140360403 Organic-Inorganic Composite Materials as a Result of Biomineralization  
A method for producing organic-inorganic composite materials includes at least one biomineralising protein and/or polypeptide-encoding recombinant polynucleotide being introduced into at least one...
US20150044731 PSYCHROPHILIC ENZYMES COMPOSITIONS AND METHODS FOR MAKING AND USING SAME  
Enzyme compositions with enhanced enzyme activity and/or thermophilic and psychrophilic stability are described. Additionally, methods and kits for making and using the enzyme compositions are...
US20150197755 EPCAM APTAMER FOR DETECTION OF CANCER STEM CELLS  
The present disclosure relates to an RNA aptamer and uses thereof, in particular, an aptamer which specifically bind to EpCAM and which demonstrates superior tumor penetrating ability.
US20140050666 SCAVENGER RECEPTOR UPTAKE FOR FABRY DISEASE ENZYME REPLACEMENT THERAPY  
The present invention relates to a composition comprising a lysosomal enzyme conjugated to a negatively charged scavenger receptor ligand. In some embodiments, the lysosomal enzyme is conjugated...
US20110118434 METHOD FOR POLYMERISING GLYCOLIC ACID WITH MICROORGANISMS  
The present invention relates to a method for producing and preparing polyglycolate (PGA) from genetically engineered organisms. More specifically, the invention relates to a method comprising two...
US20150147276 NANOTHERAPEUTICS FOR DRUG TARGETING  
The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded...
US20120201811 GENERATION AND USE OF FAB, SCFV, AND RELATED BINDING MOLECULES SPECIFIC FOR HIV-1 REV  
Described herein is the identification, though phage display, of a chimeric rabbit/human anti-Rev Fab (SJS-R1) that readily solubilized polymeric HIV-1 Rev. The Fab binds with very high affinity...
US20120045391 Formulations Targeting IGFBP7 for Diagnosis and Therapy of Cancer  
The invention relates to antibodies or fragments thereof specific for insulin-like growth factor binding protein-7 (IGFBP7). A method of raising anti-IGFBP7 single domain antibodies is also...
US20150175999 STABILIZED LACCASE ENZYME AND METHODS OF MAKING AND USING THE SAME  
Provided herein are compositions and methods for enhancing enzyme activity, half-life, thermostability, enhanced activity at elevated temperature, and/or decreasing the pH dependency of laccase...
US20140377836 CRYSTAL  
The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes,...
US20120090043 TARGETS FOR RETROVIRUS ASSOCIATED DISEASES  
The invention concerns an isolated complex comprising an HIV or HTLV protein and a human protein. Corresponding nucleic acids, vectors, host cells, host organisms, compositions, kits, medical...
US20130323752 BLID; a novel protein domain for interaction with the Bcl-2 family of proteins  
In this invention, a novel protein interaction domain is provided along with several of its variants. This domain is involved in protein-protein interactions with the Bcl-2 family of proteins. It...
US20150126387 AMPK ACTIVATOR SCREENING METHOD, AND AMPK ACTIVATOR  
A method for screening an AMPK activator, wherein inhibition of an interaction between prohibitin and AMPK is used as an index is provided. Besides, an AMPK activator comprising, as an active...
US20130266981 EXPRESSION OF CLASS 2 MANNOSIDASE AND CLASS III MANNOSIDASE IN LOWER EUKARYOTIC CELLS  
A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manα1,3 and Manα1,6 glycosidic linkages in a lower eukaryote is disclosed....
US20140336119 POLYPEPTIDES TARGETING GLYCOSYLATED MUC2 PROTEINS, METHODS OF SYNTHESIS, THEIR NUCLEIC ACIDS AND USES THEREOF  
The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the...
US20130273531 AMBIENT TEMPERATURE STABLE KITS FOR MOLECULAR DIAGNOSTICS  
A method for processing DNA polymerase and/or dNTPs for use in an amplification procedure, includes providing a solution mixture, the solution mixture including a DNA polymerase and/or dNTPs, a...
US20130130248 ENDORIBONUCLEASE COMPOSITIONS AND METHODS OF USE THEREOF  
The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant...
US20110189671 NUCLEOSIDE TRIPHOSPHATE DERIVATIVE, NUCLEIC ACID PROBE, MULTILABELED NUCLEIC ACID PROBE, METHOD FOR PRODUCTION OF MULTILABELED NUCLEIC ACID PROBE, AND METHOD FOR DETECTION OF TARGET NUCLEIC ACID  
A novel nucleoside triphosphate derivative, a nucleic acid probe, and a multilabeled nucleic acid probe that can detect a target nucleic acid conveniently and with high sensitivity, as well as a...
US20140295437 Cyanine compounds and their application as quenching compounds  
The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium,...
US20110105362 CYANINE COMPOUNDS AND THEIR APPLICATION AS QUENCHING COMPOUNDS  
The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium,...
US20140193481 STABILISED VACCINE COMPOSITION  
A component for a HIV vaccine comprising: a) an immunogenic fusion protein comprising Nef or an immunogenic fragment or derivative thereof, and p17 Gag and/or p24 Gag or immunogenic fragments or...
US20120328592 STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF  
Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing...
US20130302308 THERAPEUTIC STRATEGIES TO TREAT CNS PATHOLOGY IN MUCOPOLYSACCHARIDOSES  
The invention refers to nucleotide sequence encoding for a chimeric sulfatase, viral vectors expressing such sequences for gene therapy and pharmaceutical uses of the chimeric expressed protein....
US20110269194 MATERIALS AND METHODS FOR NUCLEIC ACID FRACTIONATION BY SOLID PHASE ENTRAPMENT AND ENZYME-MEDIATED DETACHMENT  
Materials and methods are provided for the gel-free fractionation of polynucleotide molecules. According to the present invention, fractionation is size-based or sequence-based.
US20120003714 BLENDS CONTAINING PROTEASES  
Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with...
US20130059306 PRIMER AND PROBE FOR DETECTING CHLAMYDIA TRACHOMATIS, AND METHOD FOR DETECTING CHLAMYDIA TRACHOMATIS USING SAME  
The present invention relates to an oligonucleotide which is designed on the basis of a nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2 and hybridizes with the endogenous plasmid gene of...
US20120230911 TNF-ALPHA BINDING PROTEINS  
TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A...
US20150159148 PEGYLATED ASPARTYL-TRNA SYNTHETASE POLYPEPTIDES  
The present invention provides PEGylated aspartyl-tRNA synthetase (DRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or...
US20140255378 PEGYLATED TYROSYL-TRNA SYNTHETASE POLYPEPTIDES  
The present invention provides PEGylated tyrosyl-tRNA synthetase (YRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or...
US20110305685 SUPRAMOLECULAR APPROACH FOR PREPARATION OF SIZE CONTROLLABLE NANOPARTICLES  
A supramolecular approach has been developed for preparation of size-controllable nanoparticles, from three different molecular building blocks.
US20130344099 FUSION PROTEIN FOR SECRETORY PROTEIN EXPRESSION  
There is provided a fusion protein suitable for secretion of more than one polypeptide(s) of interest (POI) comprising a signal peptide, a POI, a passenger domain comprising a beta stem domain...
US20120225447 COMPOSITIONS AND METHODS FOR QUANTITATIVELY MONITORING LIPIDS  
Provided herein are fluorescent lipid binding proteins (FLBPs). The FLBPs comprise a lipid binding domain linked to a fluorophore, whrereby the fluorophore's fluorescence emission undergoes a...
US20140147459 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA  
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were...
US20120196278 RNA POLYPHOSPHATASE COMPOSITIONS, KITS, AND USES THEREOF  
The present invention relates to the discovery of RNA 5′ polyphosphatase enzymes not previously described in the art, methods for discovery of said enzymes, compositions of said enzymes, methods...
US20140141485 ZCYTOR17 HETERODIMERIC CYTOKINE RECEPTOR  
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors...
US20150037311 TARGETED LYSOSOMAL ENZYME COMPOUNDS  
The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and...
US20130236945 Fusion Protein Having Factor VII Activity  
A fusion protein comprising factor VII (FVII) and transferrin according to the present invention has an improved specific activity of FVII compared to existing FVII fusion proteins comprising...
US20130143299 RNF8-FHA DOMAIN-MODIFIED PROTEIN AND METHOD OF PRODUCING THE SAME  
Provided is an antigen-binding protein prepared merely by a method of in vitro selection using the RNF8-FHA domain, which has no intramolecular disulfide bond and functions in cells as it is. One...
US20140255376 Regulation of Specific Spinal Neurons Regulating Pain Transmission  
A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the...
US20120149084 FUSION PROTEINS  
The invention provides a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein...
US20140227723 ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF  
Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding...
US20110275134 Arrestin Biosensor  
The present invention relates to a novel biosensor. A resonance energy transfter (RET) biosensor comprising a beta(β)-arrestin tagged with a first and a second chromophore, wherein said first...
US20140259215 METHOD FOR EXPRESSING DEOXYRIBONUCLEASE IN PLANTS  
The present invention provides, in one aspect, to a method for expressing DNase in a plant comprising growing a plant that has been transformed with a nucleic acid construct comprising a nucleic...
US20110318808 Engineered Plant Cysteine Proteases and Their Uses  
The present invention relates to potato virus NIa protease variants or fragments thereof, polynucleotides encoding them, and methods of making and using the foregoing.
US20120107902 Processes For Forming Amide Bonds And Compositions Related Thereto  
The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an...
US20110070610 Processing Enzymes Fused to Basic Protein Tags  
The invention is related to processing enzyme comprising an N-terminally attached tag derived from highly basic proteins from thermophilic bacteria. The processing enzymes are useful for modifying...
US20140045241 MICELLAR POLYSILOXANE ENZYME IMMOBILIZATION MATERIALS  
The present invention generally relates to immobilized enzymes for use in carbon capture and other systems; particularly, materials used to immobilize carbonic anhydrase are disclosed.
US20130309748 ENZYMATIC CONVERSION OF VOLATILE ORGANIC COMPOUNDS  
The present invention relates to a composition comprising a stable aqueous dispersion of polymer particles, an oxidoreductase, and a cofactor for the oxidoreductase and a method for its...