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US20090300779 |
Cancer selective auxotrophs
Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective anti tumor treatments, labeling agents, and vaccines against infection. Improved antitumor...
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US20090298762 |
CONJUGATES OF BIOLOGICALLY ACTIVE PROTEINS HAVING A MODIFIED IN VIVO HALF-LIFE
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating...
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US20090298125 |
HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES
The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid...
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US20090298119 |
Genetically encoded coumarin amino acids
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine into proteins...
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US20090298046 |
Assays for Histone Deacetylase 1/2 Selective Inhibitors
The present invention relates to an assay specific for histone deacetylases HDAC1 and/or 2 inhibitors which comprises: (i) incubating an HDAC1 and/or 2 enzymes(s) together with a protein that...
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US20090297479 |
DC-HIL CONJUGATES FOR TREATMENT OF T-CELL DISORDERS
The present invention relates to the use of DC-HIL and fragments and variants thereof to selectively target toxins to activated T-cells expressing a unique form of syndecan-4 that is not found on...
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US20090297436 |
ANTIBODIES TO IL-6 AND USE THEREOF
The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the...
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US20090286852 |
RNA containing modified nucleosides and methods of use thereof
This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing...
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US20090286279 |
Genetically programmed expression of selectively sulfated proteins in eubacteria
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such...
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US20090286261 |
METHOD FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE
An exemplary embodiment may be directed to a fluorescence polarization assay that screens compounds or agents for their affinity to hematopoietic prostaglandin D synthase (H-PGDS) based on their...
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US20090286251 |
Enzyme Reagents for Amplification of Polynucleotides in the Presence of Inhibitors
Compositions and methods are provided for amplifying polynucletoides from samples containing inhibitors that normally inhibit amplification using an enzyme blend containing a plurality of...
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US20090285933 |
Product and Process
The present invention concerns a new α-galactosidase with transgalactosylating activity isolated from Bifidobacterium bifidum . The α-galactosidase is capable of converting mellibiose to...
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US20090281353 |
Use of dimethyl disulfide for methionine production in microoragnisms
The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants...
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US20090280996 |
DELTA 17 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS
The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to...
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US20090280551 |
A REAGENT FORMULATION USING RUTHENIUM HEXAMINE AS A MEDIATOR FOR ELECTROCHEMICAL TEST STRIPS
Described herein are various embodiments of a test strip, which may be capable of measuring an analyte. The test strip may include a working electrode and a reference electrode where the reagent...
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US20090280212 |
METHOD OF PRODUCING FILAMENTOUS FUNGUS CULTURE PRODUCT
It is an object of the present invention to provide a method of adjusting productivity of enzymes, in particular, amylolytic enzymes, plant fiber degradation enzymes and proteolytic enzymes in a...
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US20090275635 |
SCREENING METHOD
The invention provides a method of modulating Wnt signalling comprising modulating Trabid activity. Preferably modulating Trabid activity comprises inhibiting; Trabid activity. The invention also...
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US20090275066 |
IMMOBILIZATION OF MEMBRANE PORTEINS ONTO SUPPORTS VIA AN AMPHIPHILE
The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof,...
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US20090275050 |
14273 receptor, a novel G-protein coupled receptor
The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The...
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US20090275047 |
CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLATE CYCLASE
The invention provides the crystal structure of the solAC catalytic domain. The structure is set out in Tables 1 to 5. The structure may be used in to model the interaction of ligands such as...
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US20090275031 |
Biomolecular nano device
Methods for measuring environmental parameters using chemical recording are provided. In some embodiments, the methods include generating a polymer comprising an ordered series of chemical units,...
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US20090274719 |
CHLAMYDIA TRACHOMATIS GENOMIC SEQUENCE AND POLYPEPTIDES, FRAGMENTS THEREOF AND USES THEREOF, IN PARTICULAR FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF INFECTION
The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis , such as cellular envelope polypeptides, which are secreted or...
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US20090271888 |
METHODS OF PRODUCING POLYKETIDE SYNTHASE MUTANTS AND COMPOSITIONS AND USES THEREOF
The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic...
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US20090269830 |
Culture System and Method for Propagation of Human Blastocyst-Derived Stem Cells
The present invention relates to a culture system for and a method for propagation of human blastocyst-derived stem cells (hBS cells) upon enzymatic dissociation into a single cell suspension. The...
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US20090269827 |
Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldadarius and related organisms, methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering...
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US20090269820 |
Dna coding for polypeptide participating in biosynthesis of pladienolide
The present invention provides polypeptides that participate in the biosynthesis of the pladienolide macrolide compounds, DNA that encodes these polypeptides and variants of this DNA, transformants...
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US20090269766 |
NUCLEIC ACID AMPLIFICATION IN THE PRESENCE OF MODIFIED RANDOMERS
The present invention is directed to a composition comprising a DNA Polymerase which is preferably thermostable, Deoxynucleotides, at least one primer oligonucleotide or a pair of amplification...
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US20090264616 |
Cyclodipeptide Synthetases and Their Use for Synthesis of Cyclo(Leu-Leu) Cyclodipeptide
Isolated, natural or synthetic polynucleotides and the polypeptides encoded by said polynucleotides, that are involved in the synthesis of cyclodipeptides, the recombinant vectors comprising said...
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US20090263879 |
Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples
This invention pertains to a method for detecting a compound in the presence of other compounds that are substantially similar in structure and metabolically related to the analyte. The invention...
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US20090263875 |
METHODS OF GENERATING PROTEIN VARIANTS WITH ALTERED FUNCTION
The present invention provides methods of designing and generating polypeptide variants that have altered function compared to a parent polypeptide. The present invention further provides a...
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US20090263554 |
Nucleic acid molecules encoding enzymes from wheat which are involved in starch synthesis
The present invention relates to nucleic acid molecules encoding enzymes which are involved in the starch synthesis in plants. These enzymes are starch synthases from wheat. The invention further...
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US20090253169 |
Use of genetically modified organisms to generate biomass degrading enzymes
The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of...
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US20090246852 |
THERAPEUTIC USE OF ANTI-CS1 ANTIBODIES
The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such...
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US20090246851 |
METHOD FOR PRODUCTION OF ENZYME
The present invention provides a process for producing an enzyme, which includes recovering an enzyme by microfiltering an enzyme-containing solution, having a cell density of 1% (v/v) or less and...
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US20090246826 |
Bi-Directional Selection Markers With Improved Activity
The present invention discloses a polypeptide selected from the group consisting of: a polypeptide having an amino acid sequence according to SEQ ID NO 3, a polypeptide having an amino acid...
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US20090246349 |
Wheat pigment
The present invention relates to genes, and markers therefor, involved in lutein production in cereal plants such as wheat. In particular, the invention characterizes ε-cyclase and phytoene...
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US20090246183 |
eNOS mutations useful for gene therapy and therapeutic screening
The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the...
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US20090239761 |
Protein arrays and uses thereof
The inventors herein describe methods for the production of a functional human, animal, plant or microbe protein arrays and methods to assay for interactions between the proteins on the array with...
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US20090239283 |
PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION (PAP)
A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification...
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US20090239281 |
Moving A Small Object in A Direction
For directional motion of a small object, a combination of at least two different properties is imparted to the object. At least one of the properties being responsive to an external influence to...
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US20090238888 |
RADICAL POLYMERIZATION METHOD AND PRODUCTS PREPARED THEREBY
In one embodiment, the present invention relates to a method for initiating radical polymerization of at least one monomer composition, the method comprising the steps of: supplying at least one...
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US20090235390 |
Isoforms of eIF-5A: senescence-induced eIF-5A; wounding-induced eIF-5A; growth eIF-5A: and DHS
The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides...
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US20090233316 |
Protein, An Antibody and Measurement of the Protein
A novel mammalian protein related to human hypothetical protein FLJ22662 (SEQ ID NO: 1) and homologous hypothetical proteins from mammal species other than Homo sapiens . The protein is expressed...
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US20090233290 |
Mutant SepRS, and method for site-specific introduction of phosphoserine into protein using the same
A mutant SepRS which is suitable for a site-specific introduction of phosphoserine into a protein is prepared by analyzing the structure and functions of a phosphoseryl-tRNA synthetase (SepRS)...
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US20090226996 |
Oxygen scavenger coating composition
A coating composition having an multicopper oxidase enzyme and an oxidizable substrate in combination with an organic binder polymer which may be dispersed or dissolved in a non-aqueous liquid...
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US20090226973 |
Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification
An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length...
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US20090226968 |
Engineering Intracellular Sialylation Pathways
Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using...
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US20090226966 |
Polypeptide having activity of aminoacyl-tRNA synthetase and use thereof
A polypeptide according to the present invention includes: an altered polypeptide obtained by altering an ArgRS, a CysRS, a MetRS, a GlnRS, a GluRS, a LysRS, a TyrRS, or a TrpRS so that an...
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US20090226964 |
Polymyxin Synthetase and Gene Cluster Thereof
The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from ...
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US20090226919 |
METHOD FOR CONSTRUCTING AN OPERON CONTAINING TRANSLATIONALLY COUPLED GENES
The present invention provides a method for constructing recombinant translationally coupled operons, a method for producing useful metabolites using the bacterium containing the coupled operons,...
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