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US20090285820 |
Methods of Treating Degenerative Disorders With Rac 1B Inhibitor
The invention relates to compositions and methods for treating degenerative disorders. More particularly, the invention relates to methods of treating amyloïd beta peptide-related disorders,...
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US20090280512 |
TUMOR MARKER FOR RENAL CANCER AND METHOD FOR DETERMINATION OF OCCURRENCE OF RENAL CANCER
The present invention provides a tumor marker more highly specific to renal cancer. The present invention provides a method for identifying the morbidity of renal cancer. A tumor marker for renal...
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US20090275633 |
Novel Tumour Suppressor
A method of diagnosing cancer includes the steps of, in a sample obtained from a subject, determining the level or activity of HDAC2. A reduced level or activity of HDAC2 is indicative of cancer....
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US20090275066 |
IMMOBILIZATION OF MEMBRANE PORTEINS ONTO SUPPORTS VIA AN AMPHIPHILE
The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof,...
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US20090275065 |
METHODS AND COMPOUNDS FOR DETECTING BETA-LACTAMASE ACTIVITY
The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a...
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US20090275063 |
Distinguishing cells in a sample by inactivating extracellular enzyme before releasing intracellular enzyme
A method for detecting the absence or presence of cells of interest in a liquid sample, wherein: (a) the sample: (i) comprises an extracellular medium containing an enzyme with a measurable...
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US20090275052 |
ADJUSTABLE MOLECULAR MOTOR MICROPOWER BIOSENSOR AND ITS APPLICATION
A regulable molecular motor micropower biosensor comprises: a rotary motor, an optical energy conversion device, a signal molecular output device, a power resource system, a protective layer, a...
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US20090274681 |
NOVEL GENE ENCODING A DNA REPAIR ENZYME AND METHODS OF USE THEREOF
An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids,...
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US20090269792 |
ACETAMINOPHEN ASSAY
In general, the present invention provides a reliable assay for the quantitative determination of p-aminophenol in an aqueous sample. More particularly, the present invention provides a rapid...
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US20090269326 |
Compositions of and methods of using sulfatases from flavobacterium heparinum
This invention is related, in part, to sulfatase enzymes and methods of their use.
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US20090263843 |
Protein labeling with cyanobenzothiazole conjugates
The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the...
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US20090263842 |
METHOD OF ASSESSING THE METASTATIC STATUS OF A PRIMARY TUMOR
The current invention provides a method for determining the metastatic potential, capability, status, or characteristics of a primary tumor from a human cancer patient by determining expression...
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US20090260090 |
APOBEC3 MEDIATED DNA EDITING
The present invention relates to methods and compositions for preventing the occurance or progression of a cancer or pre-cancerous condition associated with expression, or over-expression of human...
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US20090255811 |
BIOSENSOR COATING COMPOSITION AND METHODS THEREOF
The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The...
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US20090253157 |
METHOD OF DIRECTED DIFFERENTIATION OF PORCINE EMBRYONIC STEM CELLS AND USING THE SAID CELLS IN DRUG SCREENING
The present invention relates to a method of directed differentiation of porcine embryonic stem cells into specific neural lineages. The present invention also relates to a method for identifying...
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US20090253134 |
Cellular Pyrogen Test
The invention concerns methods, agents and kits for qualitative and quantitative detection and identification of pathogens and pathogen spectra based on endotoxins and other pyrogens.
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US20090252755 |
CLONED GENOME OF INFECTIOUS HEPATITIS C VIRUS STRAIN HC-TN AND USES THEREOF
Embodiments described herein include nucleic acid sequences, which encode hepatitis C virus of strain HC-TN, genotype 1 a , proteins and polypeptides and fragments thereof. Use of these...
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US20090239807 |
Methods and kits for diagnosing and/or assessing severity and treating gaucher disease
Methods and kits for treating Gaucher disease are provided. The methods are based on using agents capable of inhibiting proteasomal degradation of glucocerebrosidase and/or elevating a level of...
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US20090233858 |
STRUCTURE OF A PROTEIN PHOSPHATASE 2A HOLOENZYME: INSIGHTS INTO TAU DEPHOSPHORYLATION
Embodiments of the present invention relate to crystals and atomic coordinates for PP2A, as well as methods for using these atomic coordinates to prepare modulators of PP2A and inhibitors prepared...
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US20090232910 |
Biomarkers and therapeutics targets for cognitive decline
Enrichment of S and Z polymorphisms of alpha-1-antitrypsin (AAT) in distinct subsets of patients with cognitive disorder (pre-existing affective disorders and APOE2 allele carriers) suggests that...
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US20090228996 |
Means and Methods for influencing Interactions Between Dc-Sign and Dc-Sign Ligands
The invention provides a method for influencing interaction between a DC-SIGN ligand receptor that is exposed to said DC-SIGN ligand, comprising at least one Lewis X sugar epitope, or a functional...
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US20090227558 |
AMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
This invention comprises the novel compounds of formula (I)
wherein n, m, t, R 1 , R 2 , L, Q, X, Y, Z and
have defined meanings, having histone deacetylase inhibiting enzymatic activity;...
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US20090226948 |
Enzyme-based time temperature indicator
The present invention relates to a time temperature indicator for indicating temperature change over time, comprising an immobilized enzyme and a substrate of the enzyme, wherein the reaction of...
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US20090226947 |
NON-INVASIVE ENZYME SCREEN FOR TISSUE REMODELLING-ASSOCIATED CONDITIONS
Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are...
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US20090226941 |
Detection of Trichomonas
The present invention is directed to diagnostic devices and methods for detecting Trichomonas infections.
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US20090226937 |
Methods for the Detection and Monitoring of Congestive Heart Failure
Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive...
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US20090226898 |
Mitochondrial markers of ischemia
Damage to tissue, such as ischemic damage, can cause the release of mitochondrial markers. The released markers can be detected in a sample taken from a subject, indicating that the subject has...
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US20090221014 |
Enzymatic Biosensors With Enhanced Activity Retention For Detection Of Organic Compounds
Enzymatic biosensors and methods of producing distal tips for biosensor transducers for use in detecting one or more analytes selected from organic compounds susceptible to dehalogenation, organic...
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US20090221013 |
METHOD FOR QUANTIFYING LIVING COLIFORM MICROORGANISMS IN A WATER SAMPLE
The invention relates to a method of rapidly quantifying living coliform microorganisms in a sample of water in which the microorganisms are put into contact with a fluorogenic substrate that is...
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US20090220982 |
COMPOSITIONS AND METHODS FOR DETERMINING NEPHROTOXICITY
The present invention provides novel in vitro assays for determining the nephrotoxicity of a compound. These assays correlate well with in vivo nephrotoxicity and also provide high-throughput...
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US20090220479 |
EGLN2 VARIANTS AND USE THEREOF IN PREVENTING OR TREATING THROMBOEMBOLIC DISORDERS AND CORONARY HEART DISEASE
The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or...
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US20090215100 |
Process for producing sugar chain derivative, structure analysis method, and sugar chain derivative
A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group...
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US20090209489 |
Compositions for the treatment of diabetis, system PH disorders, high blood pressure, and a cancer marker system
In accordance with the present invention, there is to provide a dietary supplement that provides a mammal with the essential carbohydrates needed to maintain proper health and functionality, to...
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US20090203057 |
PROTEIN DEMETHYLASES COMPRISING A JMJC DOMAIN
Post-translational modification, including protein methylation, plays an important role in regulating protein function. The present invention provides a novel assay for evaluating demethylase...
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US20090203056 |
KIT FOR DIAGNOSIS OF CANCER
The present invention relates to a kit for assaying the activity of the human arylsulphatase or its isozymes, including 4-MUS and 4-MU. The kit can be used for initial screening, therapeutic effect...
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US20090203055 |
Compositions and methods for RNA interference with sialidase expression and uses thereof
The present invention provides RNAi agents targeted to sialidase. The RNAi agents include siRNA, shRNA, and expression vectors that comprise a template for transcription of an siRNA or shRNA. The...
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US20090202516 |
INHIBITION AND TREATMENT OF GASTROINTESTINAL BIOFILMS
Orally administered physiologically acceptable anti-biofilm compositions comprising enzymes and if desired additional components such as antimicrobials, antibiotics, antifungals, herbals, chelating...
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US20090202515 |
AGENTS FOR SUPPRESSING NEURAL FIBROTIC DEGENERATION
The present invention examined the accumulation of chondroitin sulfate proteoglycans (CSPGs). The present invention relates to neurodegeneration-suppressing agents that are suitable for gene...
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US20090202514 |
AGENTS FOR IMPROVING CHRONIC OBSTRUCTIVE PULMONARY DISEASES
The present invention relates to agents for suppressing pulmonary emphysematous lesions and agents for suppressing emphysematous lesions which are suitable for treating and/or preventing COPD,...
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US20090202513 |
RIBONUCLEASE AND THIAZOLIDINEDIONE COMPOUNDS AND THEIR USE IN METHODS TO TREAT CANCER
The present invention relates to methods and kits for the treatment of cancer. A novel drug combination comprising a ribonuclease compound and a thiazolidinedione compound has been identified as...
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US20090202512 |
PROTEINS FOR USE IN HUMAN AND ANIMAL STAPHYLOCOCCUS INFECTIONS
The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO: 1 as well as variants of this polypeptide. Furthermore, the present invention...
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US20090202502 |
HEPATIC STELLATE CELL SPECIFIC PROMOTER AND USES THEREOF
Methods and reagents for effecting transgene expression in Hepatic Stellate Cells (HSC) comprising a 2.2 kb fragment of the promoter region of the Glial Fibrillary Acidic Protein (GFAP) gene, said...
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US20090186011 |
Manufacture of Active Highly Phosphorylated Human Lysosomal Sulfatase Enzymes and Uses Thereof
This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase...
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US20090181879 |
Methods for Monitoring Neuroinflammatory Destruction of Neurons and for Treating Diseases Having an Inflammatory component related to phospholipase A2
The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods...
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US20090181379 |
MOLECULAR MARKERS OF HEPATOCELLULAR CARCINOMA AND THEIR APPLICATIONS
By means of a proteomic approach, the markers of hepatocellular carcinoma (HCC) in the liver of a knockout mouse (MAT1A−/−) have been identified for the MAT1A gene (deficient in the synthesis...
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US20090181010 |
Arginase II: a target for the prevention of atherosclerosis
The instant invention provides methods and compositions for the treatment of. atherosclerotic disease. Specifically, the invention provides methods and compositions for modulating the activity of...
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US20090170145 |
MODIFIED CREATININE AMIDE HYDROLASE HAVING IMPROVED AFFINITY FOR SUBSTRATE, AND REAGENT COMPOSITION FOR DETERMINATION OF CREATININE
[Problems] To overcome disadvantages of a known creatinine amide hydrolase, and provide a creatinine amide hydrolase having improved affinity for creatinine or having a decreased Km value for...
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US20090170144 |
DETERMINATION OF VIABLE MICROORGANISMS USING COATED PARAMAGNETIC BEADS
The present invention relates to methods for the detection of microorganisms. In one embodiment, the present invention provides methods for detecting live microorganisms in a culture by capturing...
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US20090170143 |
Determination of Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Diagnostic Marker for Renal Disorders
Methods for diagnosing renal disorders by measuring human neutrophil gelatinase-associated lipocalin (NGAL) are provided.
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US20090170069 |
Cell free methods for detecting protein-ligand binding
Provided are rapid and sensitive cell-free assay methods for detecting and/or measuring specific bimolecular or higher order interactions via reassembly of a split monomeric reporter protein, and...
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