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US20140272922 ORGAN/TISSUE DISSECTION BASIN SYSTEM  
A basin system is provided comprising a basin, a tissue supporting plate, a platform ring and a suspension rod, the basin system configured to permit a single clinician to effectively and...
US20140024010 METHOD FOR PRODUCING ARTIFICIAL SKIN MODEL, AND ARTIFICIAL SKIN MODEL  
Provided is a novel method capable of producing an artificial skin model. A method for producing an artificial skin model includes: providing coated cells (1), each of which is obtained by...
US20140187496 SGEF CONTROLS MACULAR, CORPUS CALLOSUM AND HIPPOCAMPAL FUNCTION AND DEVELOPMENT, LIVER HOMEOSTASIS, FUNCTIONS OF THE IMMUNE SYSTEM, FEVER RESPONSE ATHEROSCLEROSIS AND TUMOROGENIC CELL GROWTH  
The invention provides a composition comprising SGEF protein or gene as a therapeutic means to clinical or subclinical defects associated with anomalies of at least one from among the macula,...
US20130317569 Optogenetic Control of Reward-Related Behaviors  
Provided herein are compositions and methods for disrupting at least one reward-related behavior in an individual through the use of light-responsive opsin proteins used to control the...
US20120295835 SGEF CONTROLS MACULAR, CORPUS CALLOSUM AND HIPPOCAMPAL FUNCTION AND DEVELOPMENT, LIVER HOMEOSTASIS, FUNCTIONS OF THE IMMUNE SYSTEM, FEVER RESPONSE ATHEROSCLEROSIS AND TUMOROGENIC CELL GROWTH  
The invention provides a composition comprising SGEF protein or gene as a therapeutic means to clinical or subclinical defects associated with anomalies of at least one from among the macula,...
US20140134594 METHODS FOR CROSS-LINKING BIOPROSTHETIC TISSUE USING BIO-ORTHOGONAL BINDING PAIRS  
Methods for treating a bioprosthetic tissue are described. The methods comprise contacting the biological tissue with an anchor compound, the anchor compound comprising first and second functional...
US20140030231 METHODS AND COMPOSITIONS FOR PRESERVING TISSUES AND ORGANS  
The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a...
US20120276518 Method and Device for Perfusing Tissue by ExVivo Attachment to a Living Organism  
The present invention is a holding vessel that has bioreactor and perfusion bioreactor components, a temperature specific environment and holes for transporting substances from a living organism....
US20150212071 THREE-DIMENSIONAL, PREVASCULARIZED, ENGINEERED TISSUE CONSTRUCTS, METHODS OF MAKING AND METHODS OF USING THE TISSUE CONSTRUCTS  
Three-dimensional (3D), prevascularized, engineered tissue constructs, 3D prevascularized engineered tissue models of cancer, and bioreactors and bioreactor arrays including the tissue constructs...
US20130236879 THREE-DIMENSIONAL, PREVASCULARIZED, ENGINEERED TISSUE CONSTRUCTS, METHODS OF MAKING AND METHODS OF USING THE TISSUE CONSTRUCTS  
Embodiments of the present disclosure provide for three-dimensional (3D), prevascularized, engineered tissue constructs, 3D prevascularized engineered tissue models of cancer, and bioreactors and...
US20120282591 Compositions and Methods for Tissue Preservation  
Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function,...
US20120264103 Compositions And Method For Tissue Preservation  
Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function,...
US20150079069 METHODS FOR MODIFICATION OF TISSUES  
Methods for modification of mechanical properties or a shape of a mammalian tissue, excluding scar, blood clot, fat; including a step of contacting the tissue with an isolated eukaryotic...
US20150182665 METHODS FOR STABILIZING A BIOPROSTHETIC TISSUE BY CHEMICAL MODIFICATION OF ANTIGENIC CARBOHYDRATES  
Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence...
US20110082199 USE OF NON-TOXIC CROSSLINKING REAGENTS TO IMPROVE FATIGUE RESISTANCE AND REDUCE MECHANICAL DEGRADATION OF INTERVERTEBRAL DISC AND OTHER COLLAGENOUS TISSUES  
A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous...
US20120028234 TISSUE AND ORGAN GRAFT BIOREACTOR AND METHOD OF OPERATION  
A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts,...
US20130177898 Method of Treating Organs  
A method of treating tissue, including organs, with electromagnetic energy to decrease the fat content of the tissue comprises the steps of providing a source of electromagnetic energy, and...
US20140115728 DOUBLE KNOCKOUT (GT/CMAH-KO) PIGS, ORGANS AND TISSUES  
The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional ╬▒GAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are...
US20120258439 Protein-Free Culture Media Products  
Disclosed herein are compositions and methods for a substantially protein-free media (PFM) optimized for stem cell research.
US20140274802 ENGINEERED LIVER TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME  
Engineered, living, three-dimensional liver tissue constructs comprising: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a...
US20150135344 METHODS OF MODULATING THROMBOCYTOPENIA AND MODIFIED TRANSGENIC PIGS  
The application provides methods of modulating platelet uptake by liver sinusoidal endothelial cells and of modulating thrombocytopenia. Transgenic pigs modified to bind fewer platelets are provided.
US20120276202 COLLAGEN MATRIX FOR TISSUE ENGINEERING  
The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.
US20140128846 USE OF PULMONARY SURFACTANTS IN LUNG TRANSPLANTATION AND METHODS THEREOF  
The present invention concerns a method of treating an advanced lung disease in a patient in need thereof by lung transplantation.
US20130344163 UMBILICAL CORD PRODUCTS  
Disclosed herein, in certain instances, are tissue grafts derived from UCAM. Further disclosed herein, in certain instances, are use for tissue grafts derived from UCAM.
US20130108588 MULTIPOTENT STEM CELL CULTURES  
The invention provides methods for propagation of multipotent stem cells from human skin fibroblast samples using an appropriate medium, such as an amniotic fluid medium (AFM), and subsequent...
US20140200659 CAPPING BIOPROSTHETIC TISSUE TO REDUCE CALCIFICATION  
A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a...
US20130134064 CAPPING BIOPROSTHETIC TISSUE TO REDUCE CALCIFICATION  
A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a...
US20150111193 METHODS AND SOLUTIONS FOR TISSUE PRESERVATION  
Described herein are compositions and methods particularly useful in the medical arts. The compositions and methods may be used in connection with the preservation of a portion of a mammal, for...
US20140147830 COMPOSITIONS AND METHODS RELATED TO ORGAN OR TISSUE DECELLULARIZATION  
Embodiments include methods for decellularizing an organ or tissue comprising conditioning the organ or tissue to be decellularized by exposing the organ or tissue to an electric current, as well...
US20120052479 METHODS, COMPOSITIONS AND DEVICES FOR INDUCING STASIS IN TISSUES AND ORGANS  
The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so...
US20150064686 OXYGEN UPTAKE COMPOSITIONS AND PRESERVATION OF OXYGEN PERISHABLE GOODS  
The preservation or extension of the life of oxygen perishable products such as fresh or cooked meats; fresh vegetables and fruits; dried vegetables, fruits and meats; packaged pharmaceuticals or...
US20130288949 COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN  
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such...
US20130102521 COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN  
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such...
US20150044663 TECHNIQUE FOR REGULATING REGENERATION OF TISSUE OR FAULTY OR ABNORMAL PART IN ORGAN USING NELL-1  
The object aims to form and maintain a cell, a tissue or an organ induced by differentiation. Disclosed is a composition for inducing the differentiation of a cell capable of being differentiated...
US20150224226 METHODS OF TISSUE GENERATION  
Provided herein are methods of generating tissues and organs in vitro or ex vivo comprising depositing cells and extracellular matrix onto a surface, as well as methods of using such tissues and...
US20140147831 METHODS FOR FORMING NORMAL REGENERATED TISSUES, THE NORMAL REGENERATED TISSUES AND METHODS FOR ASSESSING SENSITIVITIES AND SO ON  
A normal regenerated tissue is formed by exposing to radiation a connective tissue or a supporting tissue originating in an organ to thereby form a feeder layer and then transplanting epithelial...
US20120288848 Multi-Dimensional Flow Pad Technology for Covering Three-Dimensional Dome Shaped Anatomies  
A three dimensional dome wrap or pad for direct patient surface tissue applications for symmetrical dome shaped anatomy and extremities is disclosed herein. The pad of the present invention...
US20130130222 DEVICE, KIT AND METHOD FOR USE IN OPHTHALMOLOGY  
The present invention refers to a device and a kit for the shipment and the preservation of corneal lenticules ready for use in a lamellar keratoplasty surgery. The present invention also refers...
US20120244067 METHODS FOR INDUCING REVERSIBLE STASIS  
The present invention concerns compositions and methods involving incubating biological materials under hypoxic or anoxic conditions to induce stasis or suspended animation. Methods of screening...
US20140242569 Poultry Performance  
Methods for increasing breast muscle weight in poultry are disclosed herein. These methods can include delivery of compositions via in ovo administration. The methods disclosed herein also...
US20150164065 ORGAN ARREST, PROTECTION, PRESERVATION AND RECOVERY  
The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist, a compound for inducing local anaesthesia...
US20140011181 ORGAN ARREST, PROTECTION, PRESERVATION AND RECOVERY  
The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist, a compound for inducing local anaesthesia...
US20120190003 ORGAN ARREST, PROTECTION, PRESERVATION AND RECOVERY  
The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist, a compound for inducing local anaesthesia...
US20140294777 IMMUNOCOMPATIBLE AMNIOTIC MEMBRANE PRODUCTS  
Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The...
US20140342345 Compositions and Methods for Refolding of Denatured Proteins  
Compounds and methods for refolding of proteins in an aqueous solution. In particular, biocompatible multiblock copolymer surfactants such as poloxamers, meroxapols, poloxamines, or polyols are...
US20140289877 METHOD FOR PRODUCING TISSUE AND ORGAN  
The present invention provides a means for reconstituting tissues and organs having mature functions. A method of preparing a tissue or an organ, comprising coculturing an organ cell with a...
US20110287403 Graft Tensioning Device  
A graft tensioning device comprising a basin capable of containing a fluid, a heating element capable of heating the fluid to an appropriate temperature, a tray disposed within the basin, and a...
US20120164622 Method for Harvesting and Preparing Porcine Hearts for Use in a Cardiac Surgical Simulator  
A method is described and disclosed for harvesting and preparing porcine hearts that may be used, among other things, as an improved analog of the human heart in cardiac simulator systems for...
US20150164064 METHODS, COMPOSITIONS AND DEVICES FOR INDUCING STASIS IN CELLS, TISSUES, ORGANS, AND ORGANISMS  
The present invention concerns the use of oxygen antagonists for inducing stasis in cells, tissues, and/or organs in vivo or in an organism overall. It includes methods and apparatuses for...
US20130189225 METHODS OF INCREASING EFFICIENCY OF VECTOR PENETRATION OF TARGET TISSUE  
Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the...