Matches 201 - 250 out of 409 < 1 2 3 4 5 6 7 8 9 >


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US20120237496 PROTEASE VARIANTS  
The present invention relates to polypeptides comprising protease variants of wild type human neprilysin having an altered specificity and/or activity. In particular the present invention relates...
US20080206228 Pharmaceutical Compositions Containing Hyaluronic Acid and Collagenase for the Topical Treatment of Wounds, Burns and Ulcers  
The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical...
US20130287817 FLOWABLE IMPLANT WITH CROSSLINKABLE SURFACE MEMBRANE  
A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable...
US20080145357 Tissue fusion method using collagenase for repair of soft tissue  
The present invention provides a method of using locally administered collagenase as a non-invasive means of enhancing cell release from the cartilage or fibrocartilage tissues adjacent to a...
US20140242064 METHODS AND APPARATUS FOR DELIVERING A THERAPEUTIC AGENT TO NASOPHARYNGEAL MUCOSA TARGETS  
A system for delivering a therapeutic agent to a nasopharyngeal mucosa target comprises a foam generating mechanism, a gas, a therapeutic agent in liquid form that inhibits mucus production, and a...
US20140348828 INHIBITION OF SECRETION FROM NON-NEURONAL CELLS  
The present invention relates to treatment of disease by inhibition of cellular secretory processes, to agents and compositions therefor, and to manufacture of those agents and compositions. The...
US20110097383 APPARATUS AND METHODS FOR ENZYMATIC ESCHAROTOMY IN BURN INDUCED COMPARTMENT SYNDROME  
Apparatus suitable for use in the prevention and treatment of burn induced compartment syndrome facilitates the rapid and efficient deployment of enzymatic compositions to the affected limb or...
US20140341879 METHODS FOR THE PREVENTION OR TREATMENT OF VESSEL OCCLUSION INJURY  
This invention provides methods of preventing or treating cardiac ischemia-reperfusion injury in a mammalian subject. The methods comprise administering to the subject an effective amount of an...
US20140271897 COMPOSITIONS, METHODS AND DEVICES FOR LOCAL DRUG DELIVERY  
This invention provide novel compositions, methods and devices for sustained drug delivery. The microencapsulated sustained drug delivery compositions are deposited using oscillating needle...
US20150056179 NEW PROCESS FOR THE PRODUCTION AND PURIFICATION OF THE COLLAGENASE ENZYME FROM VIBRIO ALGINOLYTICUS  
The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacterium...
US20080107707 POLYMERIZABLE ANTIMICROBIAL COMPOSITION  
The present invention provides a polymerizable antimicrobial composition and a method for using the same. The polymerizable antimicrobial composition of the invention comprises an antimicrobial...
US20130078295 SKIN ANTIAGING TREATMENT  
A method for skin antiaging treatment including administering Botulinum toxin to an area of facial and/or neck skin, combined with the administration of a cosmetic or pharmaceutical composition...
US20140004098 METHODS OF TREATMENT WITH ELASTASE  
The invention provides methods to for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
US20150247138 Enhanced Staphylolytic Activity of the Staphylococcus aureus Bacteriophage vB_SauS-philPLA88 Virion-Associated Peptidoglycan Hydrolase HydH5: Fusions, Deletions and Synergy with LysH5  
Virion-associated peptidoglycan hydrolases have a potential as antimicrobial agents due to their ability to lyse Gram positive bacteria on contact. Full-length HydH5, a virion-associated...
US20090202517 AGENTS FOR IMPROVING INFLAMMATORY BOWEL DISEASE  
The present inventors discovered for the first time that intestinal inflammation could be efficiently suppressed by suppressing the production or accumulation of chondroitin sulfate proteoglycans....
US20140322190 Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques  
Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases...
US20130195828 Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques  
Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases...
US20140377319 ALTERING PROTEIN CONCENTRATIONS IN CEREBROSPINAL FLUID AND/OR BRAIN INTERSTITIAL FLUID  
Devices and methods of altering protein concentrations in cerebrospinal fluid and/or brain interstitial fluid are disclosed. Devices include a support having at least one protease attached to the...
US20110311510 Compositions and methods for prion decontamination  
The invention relates to compositions and methods for prion degradation, decontamination or disinfection. The composition comprises an oxidizing agent, one or more proteases and a surfactant such...
US20140286931 BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR  
The present invention relates to new biphenyl-3-carboxylic acid modulators of beta-3-adrenoceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
US20120301453 INHIBITING INTEGRIN RECEPTOR BINDING WITH NON-NATIVE MONOMERIC DISINTEGRIN OR MONOMERIC DISINTEGRIN DOMAINS  
This invention relates to methods of inhibiting binding between a cell expressing integrin receptors specific for one or more integrins selected from the group consisting of αIIbβ3, αvβ3, αvβ5, or...
US20120141454 Methods of Use of Inhibitors of Phosphodiesterases and Modulators of Nitric Oxide, Reactive Oxygen Species, and Metalloproteinases in the Treatment of Peyronie's Disease, Arteriosclerosis and Other Fibrotic Diseases  
The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction,...
US20150182606 Multimodal Antimicrobial Therapy  
The present invention is directed to compositions and methods for preventing and/or treating diseases and disorders of patients caused by non-Staphylococcal microorganisms. In particular,...
US20100061972 Method of Treating Peyronie's Disease  
The invention is directed to methods of treating patients suffering from Peyronie's disease, methods of identifying patients suffering from Peyronie's disease and a computer program for...
US20090181007 CULTURE MEDIUM AND PHARMACEUTICAL COMPOSITION FOR REGENERATING CARTILAGE TISSUE, A METHOD, USES AND PRODUCTS RELATED THERETO  
A composition for in vitro use as a culture medium or in vivo use as a pharmaceutical composition or a medical device, capable of accelerating the differentiation of stem cells into cells with a...
US20140127233 PHARMACEUTICAL COMPOSITION FOR TREATING ISCHEMIC EVENTS  
Methods and pharmaceutical compositions for treating severe ischemic events including cerebral infarction, cardiac infarction, or pulmonary embolism, comprising a thrombolytic intervention...
US20120003203 Compositions and Methods for Treating S. Pneumoniae Infection  
The present invention relates to novel compounds that are useful for inhibition and prevention of pathogen cell adhesion and cell adhesion-mediated pathologies. This invention also relates to...
US20100183617 COMPOSITIONS AND METHODS FOR REGULATING SAS1R  
The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm...
US20100143289 UMBILICAL CORD STEM CELL SECRETED PRODUCT DERIVED TOPICAL COMPOSITIONS AND METHODS OF USE THEREOF  
Compositions including topical formulations comprising secreted products obtained from the culture medium of human umbilical cord stem cells and particular combinations of components therefrom are...
US20140065107 DEVICES, SYSTEMS, AND METHODS FOR MODULATING UTERINE FUNCTION  
One aspect of the present disclosure relates to a method for modulating uterine function in a mammal. One step of the method includes placing a therapy delivery device into direct contact with a...
US20150197739 FUSION PROTEINS AND METHODS FOR TREATING, PREVENTING OR AMELIORATIONG PAIN  
A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, which protease is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory...
US20110159005 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF  
A method for treating a patient suffering from inflammation, chronic inflammation, pain, rheumatoid arthritis (RA), osteoarthritis and osteoporosis, comprising administering an effective amount of...
US20100150899 PYRAZOLINONE SCAVENGERS OF FREE RADICAL  
The present invention relates to new pyrazolinone scavengers of free radicals, pharmaceutical compositions thereof, and methods of use thereof.
US20140242063 PHARMACEUTICAL COMPOSITIONS  
The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g.,...
US20140030249 Pharmaceutical Compositions  
The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g.,...
US20090123454 METHODS FOR TREATING ADHESIVE CAPSULITIS  
The invention relates to the discovery that collagenase injections are effective in lyse the collagenous adhesions in the shoulder and treat the disorder, adhesive capsulitis. As such, the...
US20150064166 Lyophilized Preparation of Botulinum Toxin  
There are provided a lyophilized preparation of botulinum toxin without a protein stabilizer derived from animals. The lyophilized preparation of botulinum toxin according to the present invention...
US20140086900 Lyophilized Preparation of Botulinum Toxin  
There are provided a lyophilized preparation of botulinum toxin without a protein stabilizer derived from animals. The lyophilized preparation of botulinum toxin according to the present invention...
US20100247512 Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue  
Methods are provided for regulating fat storage, carbohydrate metabolism and fatty acid synthesis using modulators of membrane type matrix metalloproteinase 1 (MT1-MMP).
US20100233151 COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES  
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II...
US20140140982 SELECTIVE SEROTONIN 2A/2C RECEPTOR INVERSE AGONISTS AS THERAPEUTICS FOR NEURODEGENERATIVE DISEASES  
Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This...
US20100040598 KIT OF PARTS COMPRISING AN ACID LABILE AND AN ACID RESISTANT PHARMACEUTICALLY ACTIVE INGREDIENT  
The present invention relates to a combination of pharmaceutical compositions adapted for oral administration one of which comprises a pharmaceutically active ingredient being acid resistant, and...
US20090010910 COMPOSITIONS AND METHODS FOR DERMATOLOGICAL WOUND HEALING  
The invention relates to compositions for debriding damaged skin comprising at least one enzymatic debriding agent and at least one antiseptic compound comprising heavy metal ions. The present...
US20130195839 Polymer-Based Compositions and Conjugates of Antimicrobial Agents  
Provided herein are water-soluble polymer conjugates and polymer-based compositions of antimicrobial agents. Also provided are methods for synthesizing and administering such conjugates and...
US20120251523 Methods of Modulating TGFbeta Signaling  
The present invention provides methods of identifying the presence of or quantifying the amount of one or more of T helper (Th) cells and iTreg cells present in a sample by identifying the...
US20090130185 Anti-Microbial Compositions Comprising a Cationic Peptide and a Glycylglycine Endopeptidase  
There is provided an anti-microbial composition comprising a cationic peptide and a glycineglycine endopeptidase. The composition has been found to be synergistic against bacteria, especially Gram...
US20120070416 Macrocyclic Proline Derived HCV Serine Protease Inhibitors  
The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of...
US20150182605 Ultra-Low Dose Lysostaphin for Treating MRSA  
The present invention is directed to compositions and methods for treating diseases and disorders of patients and, in particular, compositions and methods for treating Staphylococcus infections of...
US20110293559 CATABOLIC AGENTS  
This invention relates to the use of agents which are capable of the catabolism of components of cartilage extracellular matrix to promote cartilage regeneration within cartilage pathologies and...
US20100221237 ENZYME DISRUPTION OF BACTERIAL BIOFILMS  
Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by...

Matches 201 - 250 out of 409 < 1 2 3 4 5 6 7 8 9 >