Matches 101 - 150 out of 409 < 1 2 3 4 5 6 7 8 9 >


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US20150086531 METHODS FOR MODIFYING PROGRESSION OF OSTEOARTHRITIS  
Methods for modifying progression of osteoarthritis by local administration of a clostridial derivative, such as a botulinum toxin, to an arthritis-affected site are disclosed herein.
US20110189120 AEGYPTIN AND USES THEREOF  
The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel...
US20120237497 COMPOSITIONS AND METHODS FOR PRODUCING CLOSTRIDIAL COLLAGENASES  
The present invention provides a method for producing a drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum. The method utilizes...
US20110212161 TREATMENT SKIN DISORDERS  
Disclosed are a composition and a method for treating skin disorders, including rosacea, pityriasis rosea, erythema, rhinophyma, and rosacea-associated disorders including pimples, papules,...
US20120219506 Catenae: Serosal Cancer Stem Cells  
The present invention relates to a clonally pure population of serosal cancer stem cells (CSCs) as well as methods of producing and culturing the CSCs and uses thereof. The CSCs form catenae (free...
US20120141468 MAINTENANCE OF PLATELET INHIBITION DURING ANTIPLATELET THERAPY  
A method for reducing or maintaining platelet inhibition in a patient by administering cangrelor prior to an invasive procedure is described. The method of this invention can be used for patients...
US20110117170 Controlled Release of Growth Factors and Signaling Molecules for Promoting Angiogenesis  
The present invention comprises compositions, methods, and devices for delivering angiogenic factors and signaling molecules to a target tissue, and controlling the release of these factors and...
US20150132283 Botulinum Toxin and the Treatment of Primary Disorders of Mood and Affect  
The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and CNS disorders comprising the administration of a...
US20130177548 TREATING NEOPLASMS WITH NEUROTOXIN  
The present invention provides a method of treating a neoplasm using a neurotoxin, preferably botulinum toxin. Neurotoxin administered around a neoplasm acts to decrease the contractile forces of...
US20120189610 TREATMENT OF PAIN  
Use of a therapeutic molecule, for the treatment of specific pain conditions, wherein the therapeutic molecule is a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease,...
US20140294923 ACTH FOR TREATMENT OF MIGRAINE HEADACHE  
Provided herein are methods of treatment of migraine headaches comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog, complex or aggregate thereof, or any...
US20140127188 METHOD FOR TREATMENT OF ADIPOSE DEPOSITS  
Embodiments of the invention include methods and compositions for treatment of adipose deposits.
US20140302142 COMPOSITIONS AND METHDS FOR ENHANCING PENETRATION OF BIOLOGICALLY ACTIVE SUBSTANCES INTO TISSUES OR ORGANS  
According to this invention, compositions and methods for increasing the extent of penetration of a biologically active substance into the tissues and organs are proposed, the methods comprising...
US20150150945 Modifying Macrophage Phenotype for Treatment of Disease  
The present invention provides compositions and methods for modulating one or more phenotypes of a macrophage-related cell, e.g., a macrophage. The invention further provides methods of treating...
US20120225114 Modifying Macrophage Phenotype for Treatment of Disease  
The present invention provides compositions and methods for modulating one or more phenotypes of a macrophage-related cell, e.g., a macrophage. The invention further provides methods of treating...
US20140205589 NEW STABLE ANESTHETIC COMPOSITION FOR REDUCING SKIN REACTIONS  
A composition is described with reduced degradation rate and/or improved stability of its components. The composition can alleviate or even annihilate cutaneous reactions and can include an...
US20150010532 Clostridium Histolyticum Enzymes and Methods for the Use Thereof  
The invention relates to recombinant nucleic acid and polypeptides encoding collagenase I and collagenase II, methods for the preparation thereof and methods for the use thereof. The invention...
US20140105883 Use of Botulinum Toxin for the Treatment of Cerebrovascular Disease, Renovascular and Retinovascular Circulatory Beds  
Methods of using botulinum toxin based pharmaceuticals are disclosed. The methods cause vasodilatation and decreased flow resistance of certain vascular beds for the purpose of increasing blood...
US20100333216 Non-human gene-disrupted animal with disrupted Adam11 gene  
It is an object of the present invention to provide a non-human gene-disrupted animal with a disrupted ADAM11 gene. According to the present invention, a non-human gene-disrupted animal, wherein...
US20130171156 BMP-1 Procollagen C-Proteinase for Diagnosis and Treatment of Bone and Soft Tissue Defects and Disorders  
Uses of BMP-1 isoforms for diagnosing and treating defects and disorders of bone and soft tissues are described. Also described is a newly isolated variant of the BMP-1 isoform BMP-1-3.
US20150197741 METHODS AND COMPOSITIONS FOR TREATMENT OF TRAUMATIC BRAIN INJURY AND FOR MODULATION OF MIGRATION OF NEUROGENIC CELLS  
Disclosed herein are methods for the treatment of traumatic brain injury by transplantation of cells descended from marrow adherent stem cells that express an exogenous Notch intracellular domain....
US20150174217 Multiprotease Therapeutics for Chronic Pain  
The invention includes Clostridial neurotoxin derivatives containing at least two light chain endopeptidase domains, and nucleic acids encoding such Clostridial neurotoxin derivatives. In...
US20130251761 ORGANIC COMPOUNDS  
The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods...
US20140044695 BOTULINUM TOXIN COMPOSITIONS  
A high potency botulinum toxin pharmaceutical composition comprising two excipients (such as albumin and sodium chloride) in a weight to weight ratio of between about 1 and about 100.
US20120301455 BOTULINUM TOXIN COMPOSITIONS  
A high potency botulinum toxin pharmaceutical composition comprising two excipients (such as albumin and sodium chloride) in a weight to weight ratio of between about 1 and about 100.
US20120288509 ANALYSIS OF METHYLATED NUCLEIC ACID  
The present invention provides a method for analysis methylation patterns in DNA and identifying aberrantly methylated genes in disease tissue. The invention also provides a method of identifying...
US20140242065 Compositions for Regenerating Defective or Absent Myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
US20110243920 COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES  
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II...
US20110243919 Compositions and Methods for Treating Collagen-Mediated Diseases  
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II...
US20110189163 Compositions and Methods for Treating Collagen-Mediated Diseases  
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II...
US20100330065 COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES  
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II...
US20140271610 COLLAGEN AND ALGINATE-BASED FORMULATIONS FOR HEMOSTASIS  
The present invention relates to composition(s) comprising collagen, calcium ions and alginate, wherein the composition polymerizes in situ when contacted with blood. The composition may further...
US20140112908 NON-PROTEIN STABILIZED CLOSTRIDIAL TOXIN PHARMACEUTICAL COMPOSITIONS  
A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin, wherein the Clostridial toxin present in the pharmaceutical composition is stabilized by a...
US20150196490 NANOPARTICLE COMPOSITIONS  
The present invention describes novel nanoparticle compositions, and systems and methods utilizing them for treating disorders and/or conditions associated with the epidermal and/or dermal level...
US20150044171 Gain-of-Function ADAMTS13 Variants Resistant to Auto Antibody Inhibition and Methods of Use Thereof  
Compositions and methods for the treatment of thrombotic thrombocytopenic purpura are disclosed.
US20090098102 Cosmetic Composition Containing Enzyme and Amino Acid  
The present invention relates to a skin cosmetic composition containing enzyme and amino acid. More particularly, the skin cosmetic composition according to the invention contains enzyme and amino...
US20110104059 Membrane Associated Tumor Endothelium Markers  
To gain a better understanding of tumor angiogenesis endothelial cells (ECs) were isolated and gene expression patterns were evaluated. When transcripts from ECs derived from normal and malignant...
US20150104439 PHARMACEUTICAL REMOVAL OF NEURONAL EXTENSIONS FROM A DEGENERATING DISC  
The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated...
US20150151077 Devices And Methods For Renal Denervation  
Devices and methods that produce alterations of renal sympathetic nerve activity by use of tissue modifying implants. Devices for percutaneous delivery of implants into a renal artery or vein wall...
US20130177528 COMPOSITIONS AND METHODS FOR INHIBITING VIRAL INFECTION  
Provided herein are compositions and methods for inhibiting viral infection of a host cell. The methods comprise contacting the the host cell with an effective amount of one or more polypeptides...
US20130295156 PROGENITOR ENDOTHELIAL CELL CAPTURING WITH A DRUG ELUTING IMPLANTABLE MEDICAL DEVICE  
A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a...
US20140161783 Pharmaceutical Liquid Composition of Botulinum Toxin With Improved Stability  
Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine....
US20150060462 PORTABLE NEUROTOXIN INJECTION TRAY AND ASSOCIATED APPARATUS, SYSTEM, AND METHOD  
A portable neurotoxin injection tray apparatus that includes a vial section with multiple compartments. Each compartment is capable of storing at least one neurotoxin vial or at least one saline...
US20110002912 COMPOSITION  
The present invention relates to a composition for improving stem cell integration. The present invention also relates to a method of improving stem cell integration and kits for improving stem...
US20120100125 LOCAL DEHYDRATION FOR CARPAL TUNNEL SYNDROME  
A procedure for treating carpal tunnel syndrome can involve delivering a dehydrating agent into and/or near the carpal tunnel. The dehydrating agent can reduce swelling of the flexor tendons...
US20140017225 METALLOPROTEINASE-9 OLIGOPEPTIDES AND THEIR THERAPEUTIC USE  
The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides, SEQ ID wherein the matrix metalloproteinase oligopeptide is at least one of SEQ ID 7, 11, 12,...
US20150197740 FUNCTION AND REGULATION OF ADAMTS-1  
The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention...
US20140294846 FUNCTION AND REGULATION OF ADAMTS-1  
The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention...
US20110059065 FUNCTION AND REGULATION OF ADAMTS-1  
The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention...
US20090010918 METHODS FOR TREATMENT USING COLLAGENASE  
Methods for treatment by collagenase injections are provided, which are effective in dissolving and lysing a collagenase septa network to treat carpal tunnel, plantar fasciitis and lateral...

Matches 101 - 150 out of 409 < 1 2 3 4 5 6 7 8 9 >