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US20090317372 |
SMALL MOLECULES FOR THE REDUCTION OF HIGH BLOOD GLUCOSE LEVEL
Embodiments of the present invention include the in vivo use of a family of heterocyclic compounds containing a quaternary ammonium group as exemplified by the thioxanthone and thioxanthene...
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US20090311234 |
USE OF BETA-LACTAMASE
Class A beta-lactamase may be used for reducing side-effects in the intestine associated with antibiotic therapy with a combination of beta-lactam antibiotic and beta-lactamase inhibitor.
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US20090311233 |
MATERIALS AND METHODS DIRECTED TO ASPARAGINE SYNTHETASE AND ASPARAGINASE THERAPIES
Materials and Methods for use in treating cell proliferative disorders related to asparagine metabolism are provided. Cell proliferative disorders include such cancers as forms of leukemia, ovarian...
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US20090311236 |
Therapeutic Peptide Compositions And Methods Of Making And Using Same
Therapeutic compositions include peptide formulations having a mixture of serum, albumin, casein, peptone, pacreatin, and sodium hydroxide. The peptide compositions do not include nucleic acid or...
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US20090304667 |
Method of Regulating Mammalian Target-of-Rapamycin Activity by Interaction Between Phospholipase D and RHEB
The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog...
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US20090304665 |
Super fast-acting insulin compositions
Provided are combinations, compositions and kits containing an fast-acting insulin composition and a hyaluronan degrading enzyme composition formulated for parenteral administration. Such products...
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US20090297495 |
HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR IMPROVING PAPER STRENGTH
The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides,...
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US20090297496 |
Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
The present invention comprises methods and compositions for the treatment or alleviation of NAFLD (non-alcoholic fatty liver disease) and those conditions associated with NAFLD, including fatty...
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US20090300778 |
Neutral Sphingomyelinase-E and Its Use
The present invention provides a neutral sphingomyelinase-3 (nSMase3), a nucleic acid encoding said nSMase3, a vector containing said nucleic acid, and cells and non-human organisms transformed or...
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US20090291049 |
Targeted delivery to human diseases and disorders
The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target...
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US20090280101 |
Method for conversion of uric acid to allantoin and related enzymes
It is described a polypeptide molecule able to selectively modulate uric acid conversion into S(+)-allantoin. A pharmaceutical composition for treating uric acid related disorders and a process to...
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US20090280106 |
Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use
This invention provides peptides with novel modifications that provide suitable derivatization sites to improve the pharmacokinetic properties of the peptides. These modified peptides function in...
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US20090274680 |
Human Phospholipases
The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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US20090274715 |
TICK CHITINASE
A novel chitinase, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the chitinase, and a screening method for screening a substance...
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US20090274681 |
NOVEL GENE ENCODING A DNA REPAIR ENZYME AND METHODS OF USE THEREOF
An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids,...
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US20090274679 |
PRODUCTION AND USE OF HUMAN BUTYRYLCHOLINESTERASE
The present invention concerns the production of human butyrylcholinesterase (BuChE) in transgenic plants and use of the derived BuChE as effective countermeasures against toxic agents such as...
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US20090271881 |
MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM A RAG GENE AND USES THEREOF
An I-CreI variant, wherein one of the I-CreI monomers has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG core domain situated respectively from positions...
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US20090269326 |
Compositions of and methods of using sulfatases from flavobacterium heparinum
This invention is related, in part, to sulfatase enzymes and methods of their use.
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US20090269303 |
METHOD FOR TREATING OR PREVENTING CONDITIONS BY ELEVATION OF THE ADENOSINE LEVEL IN AN INDIVIDUAL
This invention concerns a method of inducing an elevated level of adenosine in an individual by administering to the individual an effective amount of either i) recombinant protein CD73 or ii) a...
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US20090263429 |
Method of Preparing a Hydrogel
A method of preparing a hydrogel comprises: (i) reacting a first molecule comprising a carboxylic acid group and second molecule comprising an amine group or an alcohol group with a hydrolase...
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US20090263372 |
PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF THE SYMPTOMS OF ADDICTION AND METHOD OF DIAGNOSING SAME
A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation...
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US20090263371 |
Use Polysaccharides for Promotion of Enzymatic Activity
This disclosure provides methods and compositions for the promotion of enzymatic activity of Target Enzymes, including but not limited to oligosaccharide/polysaccharide enzymes, protein enzymes,...
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US20090263370 |
METHODS FOR TREATING TACHYKININ-MEDIATED DISEASES WITH CHOLINESTERASE
Methods for treating or preventing a tachykinin-mediated disease, a skin disorder, or a symptom thereof in a mammal by administering to a mammal in need thereof cholinesterase or a pharmaceutical...
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US20090252718 |
Phospholipase(s) and Use(s) Thereof
The invention relates to phospholipase(s), isoforms, derivatives, mutants and/or fragments thereof, for the preparation of a medicament for the treatment and/or prevention of ischemia. Preferred is...
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US20090246187 |
PROCESS FOR CONCENTRATION OF A POLYPEPTIDE
The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for the treatment of diseases in mammals,...
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US20090238814 |
COMPOSITIONS AND METHODS FOR TREATING HYPOPHOSPHATASIA
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by...
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US20090238813 |
Compositions And Methods For Engineered Human Arginine Deiminases
The present invention discloses the engineering of a human enzyme with arginine hydrolytic activity suitable for human therapy. An enzyme comprising of a human sequence is not likely to induce...
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US20090238887 |
Highly Impact-Resistant Granules
The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.
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US20090232788 |
Enzyme With Microbial Lysis Activity From Trichoderma Reesei
The invention provides fungal polypeptides from Trichoderma reesei that possess anti-microbial activity, polynucleotides encoding the polypeptides, compositions comprising the polypeptides and...
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US20090232789 |
NOVEL PHARMACEUTICAL PREPARATION FOR PREECLAMPSIA, ECLAMPSIA, AND TOXEMIA, AND THEIR RELATED SYMPTOMS AND RELATED DISORDERS OF PREGNANCY
A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and the method for preparing the therapeutic agents is disclosed. The therapeutic agent is a stable pharmaceutical...
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US20090226411 |
CHEMICAL DERIVATIVES AND THEIR APPLICATION AS ANTITELOMERASE AGENTS
The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their...
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US20090228996 |
Means and Methods for influencing Interactions Between Dc-Sign and Dc-Sign Ligands
The invention provides a method for influencing interaction between a DC-SIGN ligand receptor that is exposed to said DC-SIGN ligand, comprising at least one Lewis X sugar epitope, or a functional...
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US20090220452 |
Method Of Producing A Modified (POLY) Peptide
This invention relates to a method of producing a modified (poly)peptide, said method comprising the step of modifying in an organic solvent a crown ether-bound (poly)peptide at one or more...
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US20090220478 |
Pharmaceutical active substance
Pharmaceutical active substance for treating tumors in the area of breast tissue (breast carcinoma) while using peptide toxin, a substance that acts in an antagonistic manner thereto, and/or a...
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US20090220479 |
EGLN2 VARIANTS AND USE THEREOF IN PREVENTING OR TREATING THROMBOEMBOLIC DISORDERS AND CORONARY HEART DISEASE
The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or...
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US20090220586 |
PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES
The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha...
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US20090214512 |
METHODS OF TREATING SKIN DISEASE, SCALP DISEASE, SENSITIVE SKIN OR SUPPRESSING HAIR LOSS WITH MICROBUBBLE WASHING COMPOSITIONS
The present invention provides a microbubble washing composition for washing a human body or an animal, a microbubble washing method using the microbubble washing composition, and a microbubble...
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US20090214510 |
Broad Spectrum Antiviral Compositions
The instant invention provides compositions and methods for the treatment of viral infections caused by enveloped viruses comprising phospholipase nucleic acid molecules or polypeptides, or fusion...
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US20090208479 |
Compositions and Methods for Effecting the Levels of High Density Lipoprotein (HDL) Cholesterol and Apolipoprotein AI, Very Low Density Lipoprotein (VLDL) Cholesterol and Low Density Lipoprotein (LDL) Cholesterol
Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including...
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US20090208480 |
LONG HALF-LIFE RECOMBINANT BUTYRYLCHOLINESTERASE
The present invention provides for butyrylcholinesterase (BChE) attached to polyethylene glycol (PEG) to form a complex having greatly increased mean residence time (MRT) in the system of an animal...
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US20090202516 |
INHIBITION AND TREATMENT OF GASTROINTESTINAL BIOFILMS
Orally administered physiologically acceptable anti-biofilm compositions comprising enzymes and if desired additional components such as antimicrobials, antibiotics, antifungals, herbals, chelating...
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US20090202513 |
RIBONUCLEASE AND THIAZOLIDINEDIONE COMPOUNDS AND THEIR USE IN METHODS TO TREAT CANCER
The present invention relates to methods and kits for the treatment of cancer. A novel drug combination comprising a ribonuclease compound and a thiazolidinedione compound has been identified as...
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US20090202511 |
Targeted protein replacement for the treatment of lysosomal storage disorders
The present invention relates to compositions and methods for delivering lysosomal proteins. The compositions and methods described herein permit the targeted delivery of exogenous lysosomal...
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US20090202512 |
PROTEINS FOR USE IN HUMAN AND ANIMAL STAPHYLOCOCCUS INFECTIONS
The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO: 1 as well as variants of this polypeptide. Furthermore, the present invention...
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US20090202437 |
Therapeutic Use of Lpi, a Staphylococcal Lectin Pathway Inhibitor in Inflammatory diseases
The invention relates to nucleic acid molecules encoding (poly)peptides having LPI (Lectin Pathway Inhibitor) activity, to recombinant vectors harboring such molecules, and the host cells carrying...
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US20090191206 |
Human Semen Enhancer of Viral Infection Peptides (SEVI) and Their Use
Subject of the invention are peptides corresponding to a fragment of amino acids 240-290 of human prostatic acid phosphatase. The invention also relates to nucleic acids, antibodies, medicaments...
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US20090191175 |
THERAPEUTIC METHODS USING PEG-CONJUGATED AGENTS AND DEVICES FOR PERFORMING THE SAME
The present invention discloses methods and devices for selectively removing anti-PEG antibodies from a patient's blood prior to administration of a PEG-conjugated therapeutic agent so as to...
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US20090186010 |
METHODS FOR THE IDENTIFICATION OF IKKALFA FUNCTION AND OTHER GENES USEFUL FOR TREATMENT OF INFLAMMATORY DISEASES
The invention provides a method for identifying genes involved in the NF-κB pathway comprised of the steps of determining the level of expression of a gene in an experimental sample obtained from...
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US20090186011 |
Manufacture of Active Highly Phosphorylated Human Lysosomal Sulfatase Enzymes and Uses Thereof
This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase...
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US20090181007 |
CULTURE MEDIUM AND PHARMACEUTICAL COMPOSITION FOR REGENERATING CARTILAGE TISSUE, A METHOD, USES AND PRODUCTS RELATED THERETO
A composition for in vitro use as a culture medium or in vivo use as a pharmaceutical composition or a medical device, capable of accelerating the differentiation of stem cells into cells with a...
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