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US20100003226 |
Methods and Compositions for Treating Disease
The present invention relates to methods and compositions for treating a subject comprising destroying diseased cells in the subject. The methods comprise obtaining a population of cells from a...
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US20100003286 |
PHARMACEUTICAL PRODUCT COMPRISING TISSUE OF THE MALE VEGETAL REPRODUCTIVE SYSTEM
The present invention discloses pharmaceutical products useful for the treatment of allergies, autoimmune diseases, vaccination of mammals, as well as for in vitro diagnostics. These products...
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US20100003225 |
HSP60, HSP60 PEPTIDES AND T CELL VACCINES FOR IMMUNOMODULATION
The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention...
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US20090324643 |
COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING INFECTION
This invention relates to cholesterol-sequestering agents and methods of using cholesterol-sequestering agents to treat or prevent infection. The compositions of the invention can be used in vitro...
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US20090326423 |
STIMULATION OF CARTILAGE FORMATION USING REDUCED PRESSURE TREATMENT
Provided is a method of stimulating cartilage formation at a tissue site in a mammal. Also provided is a biocompatible scaffold. Additionally, a system for stimulating cartilage formation at a...
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US20090324674 |
GENETICALLY MODIFIED HEART VALVE XENOGRAFTS
A method for producing a heart valve xenograft from bovine tissue expressing reduced or undetectable levels of I1-3 galactosyl transferase are provided.
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US20090324546 |
Method for modulating gene expression by modifying the cpg content
The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic...
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US20090324562 |
Defensin Proteins
This invention relates to the novel proteins, termed INSP108 and INSP109, herein identified as members of the defensin family of proteins and to the use of these proteins and nucleic acid sequences...
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US20090317428 |
Immunogenic T-Helper Epitopes From Human Tumour Antigens and Immunotherapeutic Methods Using Said Epitopes
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
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US20090317368 |
B7-H1, A NOVEL IMMUNOREGULATORY MOLECULE
The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the...
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US20090317369 |
COMPOSITIONS COMPRISING CARDIAC STEM CELLS OVEREXPRESSING SPECIFIC MICRORNAS AND METHODS OF THEIR USE IN REPAIRING DAMAGED MYOCARDIUM
The invention provides compositions comprising modified stem cells containing a transgene that affects the expression of at least one gene that inhibits or promotes cardiomyogenesis. In particular,...
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US20090317403 |
Use of CSF-1 Inhibitors
Disclosed is the use of inhibitors of CSF-1 activity for preparing a medicament for the treatment of tumor diseases.
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US20090311224 |
THERAPEUTIC AGENT COMPRISING LIPOCALIN 2 AGAINST CANCER METASTASIS, AND METHODS OF EARLY DIAGNOSIS AND INHIBITION OF CANCER METASTASIS USING LIPOCALIN 2
The present invention relates to a pharmaceutical composition for the inhibition of cancer metastasis, more precisely, a novel pharmaceutical composition against cancer metastasis comprising...
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US20090311226 |
COMPOSITION AND METHOD FOR TREATING ESOPHAGEAL DYSPLASIA
Enhancing the immune response to esophageal tumor cells reduces the incidence of esophageal cancer developing, recurring, or metastasizing. Esophageal cancer cells are modified to render them more...
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US20090311225 |
Compositions of and Methods of Using Stabilized PSMA Dimers
The invention includes cysteine-modified PSMA polypeptides and disulfide-bond-stabilized dimers thereof, compositions and kits containing the cysteine-modified PSMA polypeptides, including dimers...
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US20090304649 |
Methods of inducing or increasing the expression of proteoglycans such as aggrecan in cells
Methods of inducing the expression of a proteoglycan such as aggrecan in a cell are described. A method is described which includes transfecting a cell with an isolated nucleic acid comprising a...
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US20090304588 |
BIOLOGICALLY EXCITABLE CELLS
As an alternative strategy to electronic pacemaker devices, we explored the feasibility of converting normally-quiescent ventricular myocytes into pacemakers by somatic cell fusion. The idea is to...
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US20090304651 |
Insulin-Like Growth Factor II (IGF-II) Binding Factors
This invention relates to modified IGF-II binding domains of the Insulin-like Growth Factor 2 Receptor (IGF2R) which have enhanced binding affinity for IGF-II relative to the wild type IGF-II...
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US20090304654 |
METHODS FOR ISOLATING ADIPOSE-DERIVED STEM CELLS AND THERAPEUTIC USE THEREOF
The application discloses adipose tissue-derived stem cells (ADSC) and related compositions and methods. ADSCs are useful for (i) production of insulin producing cells, (ii) treatment of diabetes,...
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US20090304652 |
IDENTIFICATION AND SELECTION OF STEM CELLS BEING COMMITTED TO DIFFERENTIATE TO A SPECIFIC TYPE FOR OBTAINING A HOMOGENEOUS POPULATION OF STEM CELLS
The stem cell ( 1 ) includes a cellular DNA ( 2 ) comprising a plurality of sequences coding different genes and promoters allowing DNA-protein-interactions, at least one protein molecule ( 3 )...
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US20090304650 |
Repair of the Bone Marrow Vasculature
Stem cells repair the marrow vascular niche following bone marrow transplantation. Donor-derived vasculogenesis occurred whether whole bone marrow cells, isolated stem cells, or single stem cells...
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US20090304653 |
METHODS TO IDENTIFY POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES WHICH MAY BE ASSOCIATED WITH PHYSIOLOGICAL AND MEDICAL CONDITIONS
Disclosed are methods to identify an agent which may modulate resistance to HIV-1-mediated disease, comprising contacting at least one agent to be tested with a cell comprising human ICAM-1, and...
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US20090297487 |
METHOD FOR INTRODUCING SIRNA INTO CELLS BY PHOTOCHEMICAL INTERNALISATION
The present invention relates to a method for introducing an siRNA molecule into the cytosol of a cell, said method comprising i) contacting said cell with an siRNA molecule, a carrier and a...
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US20090297488 |
METHODS OF USING REGENERATIVE CELLS IN THE TREATMENT OF PERIPHERAL VASCULAR DISEASE AND RELATED DISORDERS
Cells present in adipose tissue are used to treat patients, including patients with PVD and related diseases or disorders. Methods of treating patients include processing adipose tissue to deliver...
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US20090297486 |
Survival, Differentiation and Structural Integration Of Human Neural Stem Cells Grafted Into the Adult Rat Spinal Cord
The present invention provides methods and compositions for treating spinal cord diseases and injuries. The methods involve transplanting neural stem cells which have been previously expanded in...
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US20090291068 |
Modulation of bio-electrical rhythms via a novel engineering approach
The present invention relates to novel compositions and methods to induce, and/or modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of...
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US20090285788 |
RANDOM RNAi LIBRARIES, METHODS OF GENERATING SAME, AND SCREENING METHODS UTILIZING SAME
This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and...
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US20090285789 |
METHODS FOR ENHANCING INNATE AND ADAPTIVE IMMUNITY AND ANTIGEN IMMUNOGENICITY
The present invention is related to a method for enhancing innate and adaptive immunity by activating dendritic cells (DCs) and macrophages, comprising administering a subject LZ-8 protein. The...
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US20090274670 |
DPH2 GENE DELETION MUTANT AND USES THEREOF
Diphtheria and Pseudomonas infections are very common worldwide. The toxins involved in the pathogenesis of those diseases act by inactivating the elongation factor-2 (EF-2), therefore blocking...
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US20090274671 |
VECTOR ENCODING HUMAN GLOBIN GENE AND USE THEREOF IN TREATMENT OF HEMOGLOBINOPATHIES
Recombinant lentiviral vectors having a region encoding a functional β-globin gene; and large portions of the β-globin locus control regions which include DNase I hypersensitive sites HS2, HS3...
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US20090274714 |
TUMOUR-ASSOCIATED PEPTIDES BINDING TO HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS I OR II MOLECULES AND RELATED ANTI-CANCER VACCINE
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
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US20090274669 |
Dendritic Cells Transiently Transfected with a Membrane Homing Polypeptide and their use
The invention provides improved methods of producing dendritic cells (“DCs”) that transiently express a membrane homing peptide and optionally at least one additional antigen. These DCs have...
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US20090274699 |
UL16 BINDING PROTEIN 4
ULBP4, a novel member of the ULBP family has been isolated and characterized. ULBP4 is a useful activator of immune effector cells, particularly of NK cells.
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US20090269320 |
VARIANTS OF PIGMENT EPITHELIUM DERIVED FACTOR AND USES THEREOF
The present invention provides anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising at least one altered phosphorylation site, polynucleotides encoding same and uses...
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US20090263364 |
Method and constructs for delivering double stranded rna to pest organisms
The present invention relates in generally to RNAi and its use in gene silencing. In particular, the present invention relates to methods and constructs for delivering double stranded RNA (dsRNA)...
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US20090263395 |
GENES AND POLYPEPTIDES RELATING TO BREAST CANCERS
The present application provides novel human genes B1194, A2282V1, A2282V2, and A2282V3 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be...
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US20090263365 |
Methods and compositions for transforming dendritic cells and activating cells
Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates...
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US20090257991 |
Engineering and Delivery of Therapeutic Compositions of Freshly Isolated Cells
The present invention relates to the transient modification of cells. In particular embodiments, the cells are immune systems, such as PBMC, PBL, T (CD3+ and/or CD8+) and Natural Killer (NK) cells....
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US20090257990 |
Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
Polynucleotide expression constructs, populations of cells and methods of treating diseases caused by dysfunction in, or damage to, excitable tissues are provided.
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US20090252714 |
Autoantigenes for Improved Diagnosis, Prognosis and Treatment of Inflammatory Neurological Diseases
According to the invention, autoantibodies, the appearance of which is characteristic of neurological autoimmune diseases, especially multiple sclerosis, are detected and the respective...
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US20090252713 |
CIRCULAR DNA MOLECULE HAVING A CONDITIONAL ORIGIN OF REPLICATION, PROCESS FOR THEIR PREPARATION AND THEIR USE IN GENE THERAPY
A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of...
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US20090252715 |
IMMORTALIZATION OF MAMMALIAN CELLS
Genomic instability in T antigen expressing cells can be overcome by modifying the gene expressing T antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the...
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US20090246182 |
METHOD FOR CULTURING CELLS DERIVED FROM THE ADIPOSE TISSUE AND USES THEREOF
The invention concerns a method for culturing cells derived from the adipose tissue and in particular the stromal vascular fraction (SVF) to induce formation of cardiomyocytes, the use of the cells...
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US20090246189 |
Methods for Promoting Neurite Outgrowth and Survival of Dopaminergic Neurons
The present invention relates generally to methods for promoting regeneration, outgrowth and survival of dopaminergic neurons comprising contacting said dopaminergic neurons with an effective...
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US20090246183 |
eNOS mutations useful for gene therapy and therapeutic screening
The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the...
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US20090238804 |
USE OF CELLS CONTAINING A SPECIFIC DNA MOLECULE AS CYTOPATHIC AGENTS TO INHIBIT THE PROLIFERATION OF CELLS
The present invention relates to the use of cells containing in their genome a specific DNA molecule, as cytopathic agents able to inhibit the proliferation of cells, when these proliferative cells...
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US20090238864 |
DNA VACCINES ENCODING HEAT SHOCK PROTEINS
The present invention is related to a method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a...
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US20090238805 |
METHODS AND COMPOSITIONS FOR INCREASING RNA INTERFERENCE
The present invention relates to compositions containing a combination of a first active component comprising one or more sulfated polysaccharides and/or glycosaminoglycans and a second active...
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US20090238807 |
CELL LINE
The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.
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US20090238806 |
TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
The present application discloses a method for preventing or retarding degeneration of intervertebral disc at an intervertebral disc defect site, which includes injecting a mammalian connective...
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