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US20150164965 Transgenic Microalgae And Use Thereof For Oral Delivery Of Proteins  
Transgenic microalgae expressing at least one exogenous biologically active protein. The protein-expressing microalgae are used for the oral delivery of the biologically active protein to the...
US20140255361 ESTROGEN-RECEPTOR BASED LIGAND SYSTEM FOR REGULATING PROTEIN STABILITY  
Disclosed herein are systems, methods and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic...
US20150037370 DIATOM-BASED VACCINES  
This invention provides diatom-based vaccines.
US20120114619 PROTEIN WITH PROMOTING EFFECTS FOR AXONAL GROWTH OF NEURONS OF CENTRAL NERVOUS SYSTEM  
This invention comprises a polypeptide, a recombinant vector, a recombinant organism as well as RNA- and DNA-sequences. Furthermore, the use of polypeptides and recombinant vectors is described....
US20150118287 SYSTEMIC DELIVERY AND REGULATED EXPRESSION OF PARACRINE GENES FOR CARDIOVASCULAR DISEASES AND OTHER CONDITIONS  
In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition...
US20110286985 METHOD OF TREATMENT USING ORGANOTYPICALLY CULTURED SKIN TISSUE COMPRISING NIKS CELLS THAT EXPRESS EXOGENOUS HIF-1A  
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the...
US20150147271 TARGETS FOR DIAGNOSIS, PROGNOSIS AND THERAPY OF ACUTE MYELOID LEUKEMIA AND MYELODYSPLASTIC SYNDROMES  
Methods are disclosed for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes using interleukin 1 receptor accessory protein and other targets.
US20080274092 Erythrocytes Containing Arginine Deiminase  
Use of erythrocytes containing arginine deirainase for the preparation of a medicinal product for lowering the plasma concentration of arginine in vivo. Said use relates in particular to the...
US20140271583 CRYOPRESERVATION OF VIABLE HUMAN SKIN SUBSTITUTES  
The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates...
US20120210462 SYNTHETIC INSECTICIDAL PROTEINS ACTIVE AGAINST CORN ROOTWORM  
Traditionally, the primary method for impacting insect pest populations is the application of broad-spectrum chemical insecticides. However, there is increasing concern about the environmental...
US20150139967 METHOD OF TREATING ISCHEMIC DISORDERS  
Provided are methods of treating ischemic disorders in a subject includes administering stromal cell derived factor-1 (SDF-1) to ischemic tissue of the subject.
US20150224148 TREATMENT OF PAIN USING PLACENTAL STEM CELLS  
Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture...
US20120328583 TREATMENT OF PAIN USING PLACENTAL STEM CELLS  
Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture...
US20140242048 Methods For Controlling Pests  
Involved is a method for controlling the pest Sesamia inferens, comprising the step of contacting Sesamia inferens with Cry1B protein. Sesamia inferens is controlled by the Cry1B protein having...
US20120010499 USE OF NANOPARTICLES FOR THE TREATMENT OF CANCER  
The invention relates to the tracking of mesenchymal stem cells (MSCs) labeled with magnetic nanoparticles using magnetic resonance imaging (MRI) and the use of this method for the treatment of...
US20120100116 NEURON GENERATION, REGENERATION AND PROTECTION  
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth...
US20140161779 METHODS FOR CONTROLLING PEST  
Involved is a method for controlling the pest Sesamia inferens, comprising a step of contacting Sesamia inferens with Cry1F protein. Sesamia inferens is controlled by the Cry1F protein having...
US20140219976 METHODS AND COMPOSITIONS FOR TREATMENT OF RETINAL DEGENERATION  
Disclosed herein are methods and compositions for treating glaucoma, using descendents of marrow adherent stem cells that have been engineered to express an exogenous Notch intracellular domain.
US20110256113 METHOD FOR PREVENTING AND TREATING DIABETES USING NEURTURIN  
The present invention relates generally to methods for preventing and/or treating pancreatic disorders, particularly those related to diabetes, by administering a neurturin protein product.
US20140112896 METHODS AND COMPOSITIONS FOR THE PROVISION OF PROTEINS DEFICIENT IN LYSOSOMAL STORAGE DISEASES  
Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for the...
US20110300113 Death Receptor CD95 Controls Neurogenesis of Adult Neural Stem Cells in Vivo and in Vitro  
The present invention relates to the activation of the CD95L/CD95 system for inducing neuronal differentiation in vitro and in vivo and the use of CD95L compositions to effect differentiation.
US20140017214 METHODS AND COMPOSITIONS FOR DELIVERY OF BIOLOGICS  
Nucleases and methods of using these nucleases for genetic alteration of red blood cells (RBCs), for example for providing for a protein lacking in a monogenic disorder or a biologic for the...
US20140170123 Hepatocyte Based Insulin Gene Therapy For Diabetes  
A method and vectors for controlling blood glucose levels in a mammal are disclosed. In one embodiment, the method comprises the steps of: treating the hepatocyte cells of a patient with a first,...
US20120315255 Hepatocyte Based Insulin Gene Therapy For Diabetes  
A method and vectors for controlling blood glucose levels in a mammal are disclosed. In one embodiment, the method comprises the steps of: treating the hepatocyte cells of a patient with a first,...
US20150216948 CYTOCHROME P450 SUICIDE GENE SYSTEM  
The invention relates to a modified human CYP4B1 protein and a nucleic acid encoding for the modified human CYP4B1 protein. The invention further relates to an expression vector comprising a...
US20140099291 METHODS AND COMPOSITIONS FOR TREATMENT OF RETINAL DEGENERATION  
Disclosed herein are methods and compositions for treating retinal degeneration, such as occurs in retinitis pigmentosa and age-related macular degeneration, using descendents of marrow adherent...
US20140219975 SWITCH COSTIMULATORY RECEPTORS  
The present invention relates generally to a fusion protein that when displayed on a cell can convert a negative signal into a positive signal in the cell. The fusion protein is a chimeric protein...
US20140335064 HUMAN SKIN EQUIVALENTS EXPRESSING EXOGENOUS POLYPEPTIDES  
The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides...
US20100255052 INTEGRATED IMPLANT SYSTEM (IIS) BIOCOMPATIBLE, BIODEGRADABLE AND BIOACTIVE, COMPRISING A BIOCOMPATIBLE STERILE POROUS POLYMERIC MATRIX AND A GEL, INTEGRATING IN SITU THE TRIDIMENSIONAL MATRIX STRUCTURE  
The present invention refers to an Integrated Implant System constituted as a gel-matrix-cells integrated system, that allows providing implants in a brief time period, for covering a great skin...
US20110027241 Intraperitoneal Delivery of Genetically Engineered Mesenchymal Stem Cells  
A method of expressing at least one protein in an animal by intraperitoneal administration of mesenchymal stem cells genetically engineered with at least one polynucleotide encoding the at least...
US20130177538 HUMAN LYSOSOMAL PROTEINS FROM PLANT CELL CULTURE  
A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or...
US20120282231 HUMAN LYSOSOMAL PROTEINS FROM PLANT CELL CULTURE  
A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or...
US20110182868 HUMAN LYSOSOMAL PROTEINS FROM PLANT CELL CULTURE  
A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or...
US20120282230 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF GENETIC AND RETINAL DISEASE  
A process of detecting the presence of or susceptibility to a disease involving the Frizzled-4 receptor is provided. The inventive method determines the presence or absence of one or more...
US20150258143 METHOD OF PROVIDING CELLULAR THERAPY USING MODIFIED NATURAL KILLER CELLS OR T LYMPHOCYTES  
A method of decreasing cytokine production and release is disclosed. In one embodiment, the method comprises the step of providing cytotoxic cells to a subject wherein the cells are preferably...
US20140079675 Repair of Neurodegenerative Diseases  
Disclosed are methods and means for treatment of neurodegenerative disease. In particular, the methods entail administration of stem cells expressing genes encoding therapeutically effective...
US20150135363 Compositions and Methods for the Control of Root Lesion Nematode  
The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Pratylenchus (root lesion nematodes). The present...
US20110171228 Methods and Compositions Relating to the Regulation of Apoptosis by MUC1 and BH3-Containing Proapoptotic Proteins  
This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or immune cell growth. The invention provides methods of inhibiting...
US20120058091 DIAGNOSTIC AND THERAPEUTIC TREATMENTS RELATED TO MITOCHONDRIAL DISORDERS  
The invention is based in part on the discovery that chromosomal disorders such as Down Syndrome can be diagnosed by assessing maternal mitochondrial status. Thus the invention relates to...
US20120171215 NOGO-A BINDING MOLECULES AND PHARMACEUTICAL USE THEREOF  
The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant <1000 nM, a polynucleotide encoding such...
US20110159043 ALLOGENEIC VACCINE AND METHODS TO SYNTHESIZE SAME  
This invention provides a retroviral vector comprising (a) a 3′LTR; and (b) an insert having (i) a promoter, (ii) a sequence encoding an immunomolecule selected from the group consisting of...
US20110135613 METHODS FOR TREATING APOLIPOPROTEIN E4-ASSOCIATED DISORDERS  
The present disclosure provides a method of increasing the functionality of a GABAergic interneuron in the hilus of the hippocampus of an individual having at least one apolipoprotein E4 (apoE4)...
US20140234275 METHOD FOR TREATING ALS VIA THE INCREASED PRODUCTION OF FACTOR H  
Methods and systems for the treatment for ALS incorporating stem cells harvested from the subject to be treated. These stem cells may be genetically altered with the addition of several genes of...
US20120121558 COMPOSITIONS AND METHODS FOR TREATING PLASMA PROTEIN DEFICIENCY DISORDERS  
The disclosure of the present application provides compositions and methods for treating a blood disorder. In at least one embodiment of a method for treating a patient with a plasma protein...
US20110027239 ADIPOSE-DERIVED STROMAL CELLS (ASC) AS DELIVERY TOOL FOR TREATMENT OF CANCER  
The present invention generally relates to use of adult Adipose-derived stromal cells (ASC) and genetically engineered ASC for the treatment of cancer. In particular, the present invention...
US20140370039 IL-12 IMMUNOTHERAPY FOR CANCER  
Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery...
US20140140969 METHODS AND COMPOSITIONS FOR MUSCULAR DYSTROPHIES  
Methods and compositions for editing of genes involved in muscular dystrophies.
US20150224172 USE OF KGF IN THE TREATMENT OF MENOPAUSAL DISORDERS  
The present invention relates to the use of keratinocyte growth factor (KGF/FGF7) and pharmaceutical compositions thereof in the treatment of vaginal atrophy, dysuria, vaginal pain and/or vaginal...
US20110059057 KERATINOCYTES EXPRESSING EXOGENOUS ANGIOGENIC GROWTH FACTORS  
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the...
US20120263693 Methods for Treating Progressive Multifocal Leukoencephalopathy (PML)  
The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.