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US20140242111 Engineered Bacteria for Oral Delivery of Glucoregulatory Proteins  
Disclosed is an oral delivery system that overcomes major barriers encountered in the gastrointestinal tract, particularly rapid proteolytic degradation and low intestinal permeability. Provided...
US20140023618 SYSTEMS AND METHODS FOR TREATMENT OF ANDROGENETIC SKIN CONDITIONS BY MICROBIAL ORGANISMS  
A specific naturally occurring or genetically modified bacterial strain can be introduced into the hair follicle of patients suffering from androgenetic alopecia as to reduce the bioavailable...
US20140271549 Use of Antibiotics to Enhance Treatment With Therapeutic Viruses  
Provided are methods for increasing the therapeutic efficacy of viral therapy by administering an antibiotic effective against commensal bacteria with the viral therapy. Included are methods for...
US20140134236 INDIVIDUALIZED CANCER THERAPY  
In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal...
US20120171230 ORAL VACCINES PRODUCED AND ADMINISTERED USING EDIBLE MICRO-ORGANISM  
The anti-pathogen vaccine of the present invention is produced in recombinant bacteria and/or transgenic plants and then administered through standard vaccine introduction method or through the...
US20110045023 Recombinant RSV Virus Expression Systems And Vaccines  
The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in...
US20150079038 SELECTIVE RECOVERY  
Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
US20120321696 Accelerating Thrombus Resolution Through Augmentation of p53 Activity  
A novel function for the p53 gene related to resolution of deep venous thrombosis is disclosed herein. Lack of the p53 gene results in impaired thrombus resolution in a clinically relevant in vivo...
US20120027845 Adenovirus AD36 E4 ORF1 Protein For Prevention and Treatment of Non-Alcoholic Fatty Liver Disease  
This invention generally relates to methods for treating or preventing the symptoms of non-alcoholic fatty liver disease, methods for reducing excessive fat from the liver, methods of improving...
US20120114619 PROTEIN WITH PROMOTING EFFECTS FOR AXONAL GROWTH OF NEURONS OF CENTRAL NERVOUS SYSTEM  
This invention comprises a polypeptide, a recombinant vector, a recombinant organism as well as RNA- and DNA-sequences. Furthermore, the use of polypeptides and recombinant vectors is described....
US20120141420 TARGETED DELIVERY OF G-CSF FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS  
The present invention relates to a method of treating Amyotrophic Lateral Sclerosis by the targeted delivery of granulocyte-colony stimulating factor to the central nervous system with an...
US20100330038 METHODS FOR EXPRESSING PROTEINS IN AXONS  
The invention relates to expressing proteins in the axons of mammalian polypeptide in neuronal axons, viruses that can be used deliver nucleic acids of the invention into neuronal axons, as well...
US20150150959 BACTERIAL BIOFILM MATRIX AS A PLATFORM FOR PROTEIN DELIVERY  
Some aspects of this disclosure provide engineered exopolysaccharide-associated proteins, engineered bacteria expressing such proteins, and engineered biofilms comprising such proteins. Some...
US20130287738 DISEASE-ASSOCIATED PROTEIN  
Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best...
US20150118287 SYSTEMIC DELIVERY AND REGULATED EXPRESSION OF PARACRINE GENES FOR CARDIOVASCULAR DISEASES AND OTHER CONDITIONS  
In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition...
US20130202639 Synthetic Herpes Simplex Viruses for Treatment of Cancers  
New recombinant oncolytic viral vectors have been constructed based on a known herpes simplex virus-1 with a single 34.5 gene and a synctial mutation (called OncSyn (OS) virus), which was designed...
US20150246083 GENETICALLY MODIFIED PROBIOTIC FOR THE TREATMENT OF PHENYLKETONURIA (PKU) DISEASE  
A GMP adapted to provide the PAL gene for the treatment of PKU when administered orally. The GMP of the present invention may include a probiotic, a PAL gene to be expressed using the probiotic,...
US20120213738 Cardiac Repair By Reprogramming of Cardiac Fibroblasts Into Cardiomyocytes  
The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo....
US20120210462 SYNTHETIC INSECTICIDAL PROTEINS ACTIVE AGAINST CORN ROOTWORM  
Traditionally, the primary method for impacting insect pest populations is the application of broad-spectrum chemical insecticides. However, there is increasing concern about the environmental...
US20130344033 RECOMBINANT PROBIOTIC BACTERIA FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY BOWEL DISEASE (IBD) AND IRRITABLE BOWEL SYNDROME (IBS)  
The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the...
US20120195859 RECOMBINANT PROBIOTIC BACTERIA FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY BOWEL DISEASE (IBD) AND IRRITABLE BOWEL SYNDROME (IBS)  
The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the...
US20120100116 NEURON GENERATION, REGENERATION AND PROTECTION  
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth...
US20120128594 SELECTIVE INFARCTED-TISSUE-TARGETING BACTERIA AND USE THEREOF  
The present invention relates to bacteria which specifically target infracted tissue and use thereof. The present invention provides a selective infracted tissue-targeting bacterium for the first...
US20130202558 RECOMBINANT REPLICATION COMPETENT ONCOLYTIC VIRUSES AND METHODS OF USE THEREOF FOR THE TREATMENT OF CANCER  
Improved NCD variants exhibiting enhanced bioavailability and stability for the treatment of cancer are provided.
US20140294771 Adeno-Associated Virus Virions with Variant Capsid and Methods of Use Thereof  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20110117058 METHOD OF TREATING GENETIC DISORDERS  
A method for the treatment of diseases associated with mutations in MYO7A or CEP290 genes, especially the Usher Syndrome type IB and Leber congenital amaurosis, by administering to a subject in...
US20120156169 RECOMBINANT MYCOBACTERIUM STRAIN EXPRESSING A MYCOBACTERIAL FAP PROTEIN UNDER THE CONTROL OF A PROMOTER ACTIVE UNDER HYPOXIA AND ITS APPLICATION FOR CANCER THERAPY  
The invention relates to a recombinant vector comprising a mycobacterial FAP protein coding sequence under the transcriptional control of a promoter active under hypoxia conditions and its use for...
US20120093776 METHODS FOR TREATING DISEASES USING A BONE MORPHOGENETIC PROTEIN  
Described herein are methods, uses, and pharmaceutical compositions for treating heart disease that include a bone morphogenetic protein (BMP). In addition, described herein are methods, uses, and...
US20140242031 Adeno-Associated Virus Virions with Variant Capsid and Methods of Use Thereof  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The...
US20120164106 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The...
US20110229439 COMPLEMENT PROTEINS  
The present invention relates to classical pathway complement proteins and their use in the prognosis and prevention of diseases involving cone photoreceptor degeneration. Specifically, the...
US20140205570 RECOMBINANT ADENO-ASSOCIATED VIRUS-MEDIATED EXPRESSION OF FRACTALKINE FOR TREATMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE DISEASES  
The subject invention pertains to the use of fractalkine (FKN, CX3CL1) and its receptor CX3CR1 for treatment of neuroinflammation and/or neurodegeneration. In one embodiment, the present invention...
US20110318307 XIAP THERAPY  
The invention features methods, compositions and kits for the treatment of retinal degenerative disorders.
US20150125425 TREATMENT OF LIVER CANCER  
An oncolytic herpes simplex virus is disclosed for use in a method of treating primary liver cancer.
US20140356327 GENE THERAPY FOR SPINAL CORD DISORDERS  
The disclosure pertains to methods and compositions for treating disorders affecting the central nervous system (CNS). These disorders include neurometabolic disorders such as lysosomal storage...
US20130039890 TREATMENT OF TUMORS WITH GENETICALLY ENGINEERED HERPES VIRUS  
Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.
US20110002890 Treatment of tumors with genetically engineered herpes virus  
Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.
US20140348792 METHODS TO REDUCE POLYPOSIS AND COLORECTAL CANCER  
Methods for reducing or inhibiting polyposis or colorectal cancer are provided. The methods comprise administering to a mammal a bacterium modified to decrease the display of lipoteichoic acid on...
US20110044947 METHODS OF TREATING CARDIAC DISORDERS  
The invention feature methods and compositions for treating ischemic and reperfusuin related injury such as cardiac disorders.
US20120328571 Method for Using a Bacillus Subtilis Strain for Prophylaxis and Treatment of Gastro-Intestinal Conditions  
The present invention relates to a method for enhancing the health of a human comprising administering to the human an effective amount of a composition comprising Bacillus subtilis QST713 or a...
US20110171228 Methods and Compositions Relating to the Regulation of Apoptosis by MUC1 and BH3-Containing Proapoptotic Proteins  
This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or immune cell growth. The invention provides methods of inhibiting...
US20140105863 POLYCISTRONIC EXPRESSION SYSTEM FOR BACTERIA  
The invention relates to polycistronic expression in gram-positive bacterium and in particular concerns polycistronic expression units comprising one or more gene endogenous to the gram-positive...
US20110274659 Biological control agent for plants  
A biological control agent for plants and a method of inoculating the plants with the biological control agent in order protect against plant disease are provided. The treatment method consists of...
US20120177605 Delivery of Polynucleotides Across the Blood-Brain-Barrier Using Recombinant AAV9  
The present invention relates to methods and materials useful for systemically delivering polynucleotides to the spinal cord. Use of the methods and materials is indicated, for example, for...
US20130129614 Microorganisms for imaging and/or treatment of tumors  
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in...
US20120244068 Microorganisms for imaging and/or treatment of tumors  
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in...
US20150098927 METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER  
The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoK╬▓) activity as well as to methods for the design of...
US20150071881 Oncolytic Adenoviruses for Cancer Treatment  
The invention relates to an oncolytic adenovirus for the treatment of cancer, containing a human DNA sequence isolating a promoter conferring selective expression on an adenoviral gene. Said...
US20120014921 TREATMENT OF STROKE AND OTHER ACUTE NEURAL DEGENERATIVE DISORDERS VIA INTRANASAL ADMINISTRATION OF UMBILICAL CORD-DERIVED CELLS  
This invention relates to methods of treating stroke by intranasal administration of umbilical cord tissue-derived cells, which are isolated from mammalian umbilical cord tissue substantially free...
US20130064850 Using Modified Plasmids to Suppress Antibiotic Resistant Pathogens  
Methods of suppressing at least one species of micro-organism that is pathological to an organism. A first embodiment includes a method of suppressing at least one species of micro-organism that...