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US20130230454 Therapeutic Angiogenesis for Treatment of the Spine and Other Tissues  
Methods for the diagnosis and treatment of ischemic spinal conditions, degenerative disc disease, back pain and/or other tissue pathologies. Patients with ischemic spine disease can be categorized...
US20100168554 Evaluating Cardiac Function With Dynamic Imaging Techniques and Contrast Media  
Methods suitable for use in diagnostic imaging or to generate a central circulatory turnover (CCT) index for an evaluation of cardiac function of a patient are provided. The resultant CCT index...
US20130017153 UNIT DOSAGE OF APADENOSON  
The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.
US20140105829 THERAPEUTIC NANOEMULSION FORMULATION FOR THE TARGETED DELIVERY OF DOCETAXEL AND METHODS OF MAKING AND USING THE SAME  
A novel nanoemulsion formulation useful for the delivery of docetaxel chemotherapeutic agents is provided, as well as methods of their preparation and use in cancer patients and for cancer imaging.
US20090016964 HYPERPOLARIZATION METHODS, SYSTEMS AND COMPOSITIONS  
The invention provides various methods and systems for providing hyperpolarized materials as well as the hyperpolarized materials so provided. In addition, a method of providing hyperpolarized...
US20120014868 METHODS TO DIAGNOSE DEGENERATIVE DISC DISEASE  
Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck or back pain so as to improve the diagnosis of...
US20120128594 SELECTIVE INFARCTED-TISSUE-TARGETING BACTERIA AND USE THEREOF  
The present invention relates to bacteria which specifically target infracted tissue and use thereof. The present invention provides a selective infracted tissue-targeting bacterium for the first...
US20140356283 Probes, Methods of Making Probes, and Methods of Use  
Embodiments of the present disclosure provide for water soluble polyethylene glycol (PEG)-polymeric melanin (PEG-melanin) nanoparticles, methods of using the PEG-melanin nanoparticle, methods of...
US20130230455 USE OF GELSOLIN TO TREAT MULTIPLE SCLEROSIS AND TO DIAGNOSE NEUROLOGIC DISEASES  
The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
US20130344000 TREATMENT OF COGNITIVE IMPAIRMENT IN A SUBJECT WITH A NEUROLOGICAL AUTOIMMUNE DISEASE  
Described herein are methods for the treatment of cognitive impairment in a subject with a neurological autoimmune disease and methods for determining whether a subject who has a central nervous...
US20130084246 METHOD AND SYSTEM FOR QUANTITATIVE RENAL ASSESSMENT  
Method and system embodiments of the present invention employ computational analysis tools running on one or more computer systems to quantitatively analyze MRI data from patients in order to both...
US20120219507 METHOD OF DETERMINING METABOLIC FUNCTION  
The present invention provides a novel lactate difference imaging (LDI) technique, allowing assessment of the metabolic responses of tissue over a period of time. This approach utilises lactate...
US20130017152 METHOD FOR THE TREATMENT OF MULTIPLE SCLEROSIS  
A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to...
US20120030780 TARGETING OF SALL4 FOR THE TREATMENT AND DIAGNOSIS OF PROLIFERATIVE DISORDERS ASSOCIATED WITH MYELODYSPLASTIC SYNDROME (MDS)  
The present invention discloses nucleic acids, proteins, and antibodies for SALL4 (including isoforms SALL4A, SALL4B, and SALL4C), a zinc finger transcriptional factor. Further, methods are...
US20110044911 Use of Functionalized Magnetic Nanoparticles in Cancer Detection and Treatment  
The present invention provides methods of detecting a cancer cell in an individual, methods of grading a cancer, and methods of treating a cancer. The methods involve use of functionalized...
US20130129614 Microorganisms for imaging and/or treatment of tumors  
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in...
US20120244068 Microorganisms for imaging and/or treatment of tumors  
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in...
US20110293527 Modified vaccinia virus strains for use in diagnostic and therapeutic methods  
Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as...
US20130202525 MULTIFUNCTIONAL NANOPLATFORMS FOR FLUORESCENCE IMAGING AND PHOTODYNAMIC THERAPY DEVELOPED BY POST-LOADING PHOTOSENSITIZER AND FLUOROPHORE TO POLYACRYLAMIDE NANOPARTICLES  
A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.
US20130149250 HYPERPOLARIZED AGENTS FOR MRI CHARACTERIZATION OF REDOX SYSTEMS IN VIVO  
The present invention provides a MRI probe of use in detecting and characterizing redox systems in vivo. Also provided are methods of using the probe in MR imaging experiments for diagnosis of...
US20120076733 POST-BIOPSY CAVITY TREATMENT IMPLANTS AND METHODS  
A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix...
US20110091376 CATATONIC STEROID ANTIMICROBIAL DIAGNOSTIC, DETECTION, SCREENING AND IMAGING METHODS  
The invention relates to diagnostic, detection, screening and imaging methods. In various embodiments, methods of diagnosis, detection, screening and imaging include administering a cationic...
US20120052003 MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY  
Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by...
US20110064650 MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY  
Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by...
US20120093718 LIPOSOMAL NANOPARTICLES AND OTHER FORMULATIONS OF FENRETINIDE FOR USE IN THERAPY AND DRUG DELIVERY  
Formulations of neutral retinoids, in particular fenretinide (HPR) in the form of lipid nanoparticles, solid dipersions and emulsions are disclosed. These compositions are used to treat diseases...
US20110177002 CYLIC POLYAMINES FOR BINDING PHOSPHATIDYLSERINE  
The invention pertains to a compound for detecting cell death. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The...
US20120121515 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS  
Methods of treating and evaluating subjects having neoactive mutants are described herein.
US20120027686 HK1-BINDING PROTEINS  
The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides.
US20140205541 Method for Detection of Characteristics of Organ Fibrosis  
The disclosed invention is a method for detecting indications of the presence of liver disease and other fibrotic diseases using a magnetic-resonance based technique for measuring fine tissue and...
US20100310451 ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A)  
The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a...
US20120308484 Clonal strains of attenuated vaccinia viruses and methods of use thereof  
Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms...
US20120087859 NANOCARRIER HAVING ENHANCED SKIN PERMEABILITY, CELLULAR UPTAKE AND TUMOUR DELIVERY PROPERTIES  
The present invention relates to a biopolymer-modified nanocarrier in which chitosan is bound to a water-soluble biocompatible polymer that has been crosslinked via a photo-crosslinkable...
US20120197114 NANOCARRIERS FOR IMAGING AND THERAPY APPLICATIONS  
Nanocarriers and methods of preparation and use of nanocarriers are presented. In some embodiments, a nanocarrier composition comprises an organic liquid comprising a plurality of nanoparticles...
US20100331815 TRANSLUMINAL DELIVERY OF ONCOLTYIC VIRUSES FOR CANCER THERAPY  
Methods, apparatus and compositions are provided for treatment of cancer of a selected organ by intraluminal delivery of oncolytic agents through a blood vessel or duct leading to the cancer...
US20110236307 IN VIVO IMAGING METHOD  
The present invention provides an in vivo imaging method that facilitates the diagnosis of Parkinson's disease (PD) at an early stage. Early diagnosis is particularly advantageous as...
US20140296836 GOLD-IN-SILICON NANOASSEMBLY FOR THERMAL THERAPY AND METHODS OF USE  
The present invention provides methods and compositions for the nanotechnology-based therapy of one or more mammalian diseases. Disclosed are gold-in-porous silicon nanoassemblies that are...
US20120064009 METHODS OF LEUKEMIA CELL DETECTION  
Methods are provided for, inter alia, determining the presence of leukemia cells in a subject, determining the change or potential change in the number of leukemia cells in the subject with time,...
US20110135575 METALLOPROTEIN MRI CONTRAST AGENTS AND RELATED METHODS  
The present invention generally relates to Magnetic Resonance Imaging (MRI) analysis of the location, presence, and/or quantity of a particular molecule or material. In some embodiments, the...
US20140170073 NANOPARTICULATE PROBE FOR IN VIVO MONITORING OF TISSUE OXYGENATION  
A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic...
US20120276011 NANOPARTICULATE PROBE FOR IN VIVO MONITORING OF TISSUE OXYGENATION  
A new class of micro- and nano-particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging...
US20120128581 Sincalide Formulations  
The invention features sincalide formulations that include an effective amount of sincalide, a bulking agent/tonicity adjuster, a stabilizer, a surfactant, a chelator, and a buffer. The invention...
US20120107229 NOVEL NANO-PROBES FOR MOLECULAR IMAGING AND TARGETED THERAPY OF DISEASES  
The present inventions relate to compositions and methods for imaging and treating atherosclerotic diseases, pathogen infections, and tumors by administering actively targeting magnetic...
US20120087860 METHODS FOR IN VIVO CANCER DETECTION, DIAGNOSIS AND THERAPY USING MULTIDOMAIN BIOTAGS  
In another embodiment, a method for detecting and/or diagnosing a cancer in a subject is provided. The method may include administering an effective dose of a biotag to a subject, or...
US20120283503 NANOPARTICLE LOADED STEM CELLS AND THEIR USE IN MRI GUIDED HYPERTHERMIA  
The present invention provides stem cells loaded with bi-functional magnetic nanoparticles (nanoparticle-loaded stem cells (NLSC)) that both: a) heat in an alternating magnetic field (AMF); and b)...
US20130189187 NANO-SCALE CONTRAST AGENTS AND METHODS OF USE  
Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a...
US20110081293 METHODS AND COMPOSITIONS RELATED TO CLOT-BINDING LIPID COMPOUNDS  
Disclosed are compositions and methods related to clot-binding head groups. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
US20150258271 METHODS OF ASSESSING INTRADUCTAL DISEASE  
According to some embodiments, a method of evaluating an extent of intraductal disease in a breast of a subject comprises identifying a target duct of the breast of a subject, wherein the target...
US20110027188 Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers  
An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the...
US20130028837 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING  
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds...
US20120276006 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING  
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds...