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US20090311185 |
Peptide having antianxiety activity and screening method therefor
The objects of the present invention are to provide a polypeptide having an antianxiety activity; a therapeutic agent containing the polypeptide; a method for treating anxiety using the...
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US20090311186 |
METHOD FOR CONTROLLING THE THERAPY OF PATIENTS SUFFERING FROM CARDIAC INSUFFICIENCY BY MEANS OF IN VITRO DETERMINATION OF THRESHOLD VALUES OF VASOACTIVE PEPTIDES
Disclosed is a method for controlling the therapeutic treatment of a patient suffering from cardiac insufficiency. In said method, it is determined how the concentration of at least one of the...
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US20090311187 |
Methods for predicting patient response to modulation of the Co-stimulatory pathway
The invention described herein relates to diagnostic and therapeutic methods and compositions useful for predicting the likelihood a patient will have favorable response to the administration of a...
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US20090311188 |
IN VIVO METHODS OF IDENTIFYING COMPOUNDS WHICH TARGET SUPPRESSED CANCER CELLS
In vitro and in vivo methods for identifying compounds capable of targeting suppressed cancer cells such as micrometastatic cells. The in vitro method includes the steps of comparing the response...
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US20090304596 |
Methods for Predicting Psychotropic Drugs Which Elicit Weight Gain
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that...
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US20090304594 |
Methods for Predicting Treatment Response Based On the Expression Profiles of Protein and Transcription Biomarkers
The invention disclosed herein describes novel biomarkers useful for risk assessment, screening, prognosis and selection and monitoring of therapy for HDAC mediated cell proliferative disorders. In...
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US20090304595 |
ANIMAL MODEL AND A METHOD FOR PRODUCING AN ANIMAL MODEL
The present invention discloses a non-human animal model for a hereditary autosomal dominant disease. The non-human animal model expresses at least one phenotype associated with the disease and is...
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US20090297451 |
INFECTION MODEL FOR DEVELOPING CHEMOTHERAPEUTIC AGENTS
The present invention relates to a small animal model useful in identifying novel therapies for treating pathogenic diseases. This flexible biotechnology tool is valuable for developing novel...
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US20090297450 |
Tumor homing molecules, conjugates derived therefrom, and methods of using same
The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a...
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US20090297452 |
METHOD FOR QUANTIFICATION OF NEUROTOXIN
The present invention relates to a method for quantitatively measuring the muscular relaxing activity of a neurotoxin. Specifically, based on an extent of the activity of muscular relaxation of a...
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US20090297453 |
DIAGNOSTIC PROCEDURES USING DIRECT INJECTION OF GASEOUS HYPERPOLARIZED 129XE AND ASSOCIATED SYSTEMS AND PRODUCTS
A method of screening for pulmonary embolism uses gaseous phase polarized 129 Xe which is injected directly into the vasculature of a subject. The gaseous 129 Xe can be delivered in a controlled...
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US20090293138 |
ANIMAL MODELS CARRYING TUMORS EXPRESSING HUMAN PROSTATE CANCER-SPECIFIC ANTIGEN AND METHOD FOR ANALYZING PREVENTION AND TREATMENT EFFICACY OF DENDRITIC CELLS-DERIVED IMMUNOTHERAPEUTICS
A method for analyzing the prevention and treatment efficacy of a dendritic cell-derived immunotherapeutic for prostate cancer using an animal model carrying tumors expressing a human prostate...
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US20090285758 |
IN VIVO SYSTEM TO MONITOR TISSUE RESPONSES IN BIRDS
Methods of evaluating the tissue response to an agent in birds are provided. Also disclosed are methods of monitoring exposure to agents in birds and methods of determining the efficacy of vaccines.
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US20090280062 |
LONGEVITY-PROMOTING EFFECTS OF ACETIC ACID AND REISHI POLYSACCHARIDE
A composition of acetic acid and a composition of acetic acid and RF 3 effecting expression of DAF-16 in C. elegans , wherein the at least acetic acid and the RF 3 polysaccharide is effective to...
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US20090274626 |
TARGETING TNF-alpha CONVERTING ENZYME(TACE)- DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY
The invention provides methods for modulating tumor cell proliferation by contacting cells (e.g. tumor cells) with a TACE inhibitor and a compound that inhibits EGFR tyrosine kinase, whereby the...
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US20090274627 |
Composition for Regeneration of Periodontal Soft Tissue and Method for Producing the Same
It is intended to provide a composition for regeneration of periodontal soft tissue less invasively and a method for producing the composition. The composition for regeneration of periodontal soft...
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US20090269280 |
METHOD FOR ACTIVATION OF TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY A, MEMBER 1 USING ACETALDEHYDE
The present invention relates to a method for activation of TRPA1 (transient receptor potential cation channel, subfamily A, member 1) using acetaldehyde, more precisely a method for selecting a...
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US20090269281 |
Calcium/Calmodulin-Dependent Protein Kinase Kinase as a Control Point for Cardiac Hypertrophy
The present invention includes compositions and methods for treating a patient with cardiac hypertrophy by providing the patient with an effective amount of a Calmodulin kinase kinase inhibitor...
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US20090269282 |
Methods for treating, preventing and diagnosing procine ttv infection
Compositions and methods for treating, preventing and diagnosing Torque teno virus (TTV) infection in pigs are disclosed. Also described are methods of identifying compounds for the treatment and...
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US20090263324 |
Animal Model With Induced Arrhythmia
Provided are a model animal physiologically similar to humans, enabling a highly reproducible evaluation of the onset of drug-induced long QT syndrome, a method of generating the same, and an...
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US20090257955 |
Sheep model of neuropathic pain behavior and uses thereof
Methods for producing peripheral nerve injury in sheep are provided. The sheep model provides a model of persistent neuropathic pain in humans. Methods for drug delivery are provided. Also provided...
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US20090257956 |
Treatment Method for Treatment of Erectile Dysfunction and Premature Ejaculation
A method for a same visit treatment for erectile dysfunction and premature ejaculation. The method includes: performing a diagnostic on the patient using physical conditions of the patient;...
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US20090257954 |
Development of a simple animal model for infection by viruses and other obligate intracellular parasites
The present invention provides methods for studying pathogenesis of mammalian viruses. In particular, the present invention provides a nonhuman animal model system for studying disease mechanisms...
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US20090252683 |
Composition Comprising Cross-Species-Sepecific Antibodies and uses Thereof
The present invention relates to uses of bispecific antibodies exhibiting cross-species specificity for evaluating the in vivo safety and/or activity and/or pharmacokinetic profile of the same in...
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US20090252685 |
HIGH PENETRATION PRODRUG COMPOSITIONS OF PROSTAGLANDINS AND RELATED COMPOUNDS
The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of prostaglandins or prostaglandin analogs which are capable of crossing...
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US20090255003 |
Diagnostic and therapeutic target SLC39A11 proteins for neurodegenerative diseases
The present invention discloses a dysregulation of the SLC39A11 gene and the protein products thereof in Alzheimer's disease patients. Based on this finding, the invention provides methods for...
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US20090252684 |
Determination of tissue-specific profile of amino acid requirements form the relationship between the amounts of tRNAs for individual amino acids and the protein-bound amino acid profile of the tissue
Systems and methods by which optimal profiles of amino acids for specific tissues can be determined. The results of these systems and methods can then be sued to generate medical nutrition products...
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US20090246138 |
METHOD OF IMAGING METABOLIC FUNCTION
A contrast imaging method e.g. of the T2* weighted “BOLD” type is adapted by use together with an oxygen challenge to provide imaging for the assessment of the metabolic responses of tissue...
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US20090246139 |
Efficient methods to isolate effectors of proteins involved in olfactory or chemosensory pathways and efficient methods to use these effectors to alter organism olfaction, chemosensation, or behavior
This invention provides methods and compositions for identifying effectors, binding partners, or other molecules that interact with the proteins involved in the chemosensory pathway; examples of...
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US20090238762 |
Method for treating joint damage
Methods of treating joint damage in a subject eligible for treatment are provided involving administering an antagonist that binds to a B-cell surface marker, such as CD20 antibody, to the subject...
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US20090238763 |
HIGH PENETRATION COMPOSITIONS AND USES THEREOF
The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for non-steroidal anti-inflammatory agents...
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US20090233871 |
Complexed polypeptide and adjuvant for improved vaccines
Immunogenic polypeptides having the capability to precipitate and focus a CpG adjuvant exhibit enhanced in vivo priming of a cytotoxic T-lymphocyte (CTL) response. Accordingly, compositions that...
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US20090232740 |
Methods of detecting cancer cells and use of same for diagnosing and monitoring treatment of the disease
A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell...
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US20090232739 |
Method of in Vivo Screening for cardiac Toxic Agents Using Teleost
This invention relates to a method of screening agents for cardiotoxicity based on the observations of the alteration of heart rate and heart rhythm, using teleost embryos and larvae. This...
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US20090226375 |
MICRO-RNAs THAT MODULATE SMOOTH MUSCLE PROLIFERATION AND DIFFERENTIATION AND USES THEREOF
The present invention relates to the identification of microRNAs that regulate smooth muscle cell proliferation and differentiation, including the miR-143/miR-145 cluster. Methods of treating...
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US20090226373 |
METHOD OF DETERMINING THE EFFECT OF A SPILL ON A MARINE ENVIRONMENT
A method of determining the effect of a spill on a marine environment, in which physical and chemical sensors are arranged with living organisms ( 4, 6 ) fitted with instruments, at an appropriate...
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US20090226374 |
ANAPHYLATOXINS FOR DETECTING CLINICAL CONDITIONS
Non-allergic hypersensitivity reactions can be observed in a sample of cells from a subject in response to anaphylatoxins. Accordingly, methods are provided for detecting clinical conditions such...
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US20090220426 |
Biodegradable Inverted-Opal Structure, Method for Manufacturing and Using the Same, and Medical Implant Comprising the Biodegradable Inverted-Opal Structure
(Problems) The object of the present invention is to provide an inverted-opal structure which is excellent in biodegradability, biocompatibility, and pH responsiveness, has specific light...
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US20090220427 |
Drug Resistance and Methods of Reversing
Described herein is a cellular marker, MyD88, useful for assessing an individual's (patient's) sensitivity (or resistance) to chemotherapy, particularly sensitivity (or resistance) to...
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US20090220425 |
Method to Quantitatively Measure Effect of Psychotropic Drugs on Sensory Discrimination
A method for evaluating an effect of a psychotropic compound or a treatment on a neuronal activity of an animal including determining a change in the amount of information generated by neurons in...
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US20090220428 |
Insect Repellent and Process for Identifying Other Insect Repellent Molecules
This invention is based on the identification of the role played by the receptor mX on certain insects through the behavior evinced in the taste sensory reactions of these insects. The invention...
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US20090214425 |
TUMOR THERAPY WITH REPLICATION COMPETENT SINDBIS VIRAL VECTORS
Disclosed herein are methods for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal cells of the same lineage comprising...
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US20090214532 |
ANKTM1, A Cold-Activated TRP-Like Channel Expressed in Nociceptive Neurons
The methods and compositions of the invention are based on a method for measuring nociceptive responses in vertebrates, including humans and other mammals utilizing a newly discovered...
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US20090214431 |
IDENTIFICATION OF ERGOTHIONEINE TRANSPORTER AND THERAPEUTIC USES THEREOF
The transporter that translocates ergothioneine has been identified. Described are methods for identifying and obtaining compounds capable of modulating ergothioneine transport as well as the use...
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US20090208416 |
MONOCLONAL ANTIBODIES AGAINST NKG2A
The present invention relates to methods of treating immune disorders, particularly autoimmune or inflammatory disorders, and methods of producing antibodies and other compounds for use in...
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US20090202440 |
MODEL ANIMAL OF DENDRITIC CELL IMMUNORECEPTOR GENE KNOCKOUT DISEASE
It is intended to disclose the function of dendritic cell immunoreceptor (DCIR) and clarify its role in the onset of autoimmune arthritis. It is also intended to provide a method of screening a...
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US20090202439 |
Methods for treatment of angiogenesis
The present invention includes methods for treatment and prophylaxis of diseases, post-surgical disorders and bacterial infections associated with lactosylceramide. The methods generally provide...
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US20090196825 |
CD38 AND OBESITY
This document provides methods and materials relating to obesity. For example, methods and materials related to treating obesity and identifying agents having the ability to treat obesity are...
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US20090191127 |
OMENTUM AND USE THEREOF
In some embodiments, mammalian omentum and methods of using the same for treating symptoms and/or conditions related to dementia are provided. In addition, a composition comprising the omentum...
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US20090185980 |
IN VIVO DRUG SCREENING SYSTEM
The present invention provides imaging devices. The present invention also provides in vivo drug screening systems. The present invention further provides a method for in vivo drug screening.
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