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US20120009125 |
APOE4 AND APOJ BIOMARKER-BASED PREVENTION AND TREATMENT OF DEMENTIA
Methods, kits, screens, assays, treatments and treatment regimes for treating a patient at risk for or suffering from dementia, and particularly Alzheimer's dementia which are based upon...
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US20110200531 |
TREATMENT AND DIAGNOSIS OF CENTRAL NERVOUS SYSTEM DISORDERS
The invention relates to the use of tetramethylpyrazine (TMP) for the treatment of patients at risk for the development of, or diagnosed as having, CNS disorders such as Alzheimer's disease (AD),...
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US20110217239 |
SYSTEM AND METHOD OF EVALUATING A PROTEIN OF INTEREST ON TUMOR GROWTH INHIBITION WHILE FOLLOWING THE TUMOR IN VIVO OR IN VITRO
Disclosed herein are systems and methods for evaluating a protein of interest on growth inhibition of a tumor while following the tumor in vivo or in vitro through a co-expressed visible marker....
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US20110150775 |
GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS
The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods...
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US20110081296 |
SYSTEMS AND METHODS FOR IDENTIFICATION OF CILIOPATHY THERAPEUTICS
The invention provides systems and methods for identifying therapeutic targets for treating a disease including a ciliopathy. The invention further provides for drug discovery, and animal model...
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US20110008258 |
METHODS RELATING TO BREATHING DISORDERS
Methods for treating breathing disorders by inhibition of the induced PGE2 pathway in a mammalian subject, methods for assessing apnea, hypoxic ischemic encephalopathy or perinatal asphyxia by...
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US20110027184 |
PROTEIN C PATHWAY ASSOCIATED POLYMORPHISMS AS RESPONSE PREDICTORS TO ACTIVATED PROTEIN C OR PROTEIN C-LIKE COMPOUND ADMINISTRATION
The invention provides methods, nucleic acids, compositions and kits for predicting a subject's response to treatment with activated protein C or protein C like compound to identify subjects having...
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US20110195026 |
PROTEIN
The present invention provides methods and compositions for the treatment of and for screening, diagnosis and prognosis of colorectal cancer, for monitoring the effectiveness of colorectal cancer...
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US20120070379 |
IMMUNOTHERAPY REGIMES DEPENDENT ON APOE STATUS
The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
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US20110158912 |
METHOD AND DEVICE FOR DETERMINING THE SEVERITY OF A PAIN DISORDER
A method for determining the severity of a pain disorder in a subject, comprising the steps of: (i) topically applying an effective amount of menthol or a functional equivalent thereof to the...
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US20110206615 |
PROBE REAGENT FOR MEASURING OXIDATIVE STRESS
The present invention relates to fluorescent or luminescent probe reagents for measuring oxidative stress in a cell or an organism. Examples of the probe reagents include: a fluorescent or...
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US20100297018 |
Prognosis and therapy of liver failure
A method for assessing prognosis in an individual suffering from liver failure, which method comprises detecting endotoxin in the individual, for example by determining the neutrophil function in...
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US20110256063 |
MEX3C REGULATION AND TARGET TO CONTROL OBESITY AND DIABETES
MEX3C deficiency impairs the development of white and brown adipose tissue. Hence the present invention provides, among other things, a method of screening a candidate compound for activity in...
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US20120087865 |
TREATMENT OF ISCHEMIA
A system, including methods and compositions, for treatment of ischemia.
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US20110150771 |
CHIMERIC WEST NILE/DENGUE VIRUSES
The disclosure provides chimeric West Nile/Dengue viruses comprising non-coding regions, non-structural proteins, and a C protein from a West Nile virus and prM and E proteins from a Dengue virus....
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US20100143256 |
ELECTROENCEPHALOGRAPHY BASED SYSTEMS AND METHODS FOR SELECTING THERAPIES AND PREDICTING OUTCOMES
A method and system for utilizing neurophysiologic information obtained by techniques such as quantitative electroencephalography (QEEG), electrode recordings, MRI in appropriately matching...
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US20110083200 |
Method For Testing Efficacy Of Treatment Of Neurologic Disorders
The method of the invention is useful for evaluating pharmaceutical compositions for treatment of neurological diseases encompassing neurological or neurodegenerative diseases associated with...
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US20110280808 |
Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of...
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US20110256064 |
Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of...
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US20120087864 |
METHOD FOR DIAGNOSING AND/OR EVALUATING RETINAL DISEASE
The present application provides a method for diagnosing and/or evaluating the presence or absence, severity or degree of the improvement of a retinal disease in a subject, which comprises...
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US20100299765 |
MODALITIES FOR THE TREATMENT OF DEGENERATIVE DISEASES OF THE RETINA
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
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US20100329985 |
TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES
The present invention relates to the use of fragments of heat shock proteins for the treatment and/or prevention of autoimmune diseases such as arthritis or inflammatory diseases such as...
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US20110150774 |
SCREENING FOR MODULATORS OF CES1 AND/OR CES3 FOR THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA
An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea,...
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US20110150776 |
Method for Testing and Treating Delayed Food Allergies
A method for testing, treating, and preventing delayed food allergies includes: receiving detailed symptom, medical, and dietary histories from a patient; formulating a combination of one or more...
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US20120114561 |
METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
Methods for treating neurodegenerative disorders, including Parkinson's disease, are provided. The methods comprise administrating a therapeutically effective amount of oxytocin or oxytocin analogs...
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US20110189099 |
ATTENUATED MYCOPLASMA GALLISEPTICUM STRAINS
The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated...
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US20110171134 |
(6S)-5-METHYLTETRAHYDROFOLIC ACID FOR THERAPY OF TISSUE INJURY
The present invention relates generally to the field of methods useful in treating tissue injury. More specifically, the present invention relates to (6S)-5-methyltetrahydrofolic acid compounds,...
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US20120014879 |
USE OF TUMOR NECROSIS FACTOR-alpha RECEPTOR p75 FOR TREATMENT OF ISCHEMIA-INDUCED NEOVASCULARIZATION
Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various...
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US20110027186 |
TAZ/WWTR1 FOR DIAGNOSIS AND TREATMENT OF CANCER
We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to...
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US20110243854 |
Methods and systems for identifying modulators of longevity
Methods of treating disorders such as neurofibromatosis-1 are provided, including methods in which catalytic antioxidants such as metalloporphyrins are administered. Methods of regulating...
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US20110123455 |
RATIONAL DESIGN OF REGENERATIVE MEDICINE PRODUCTS
The present invention concerns a non-biased, combinatorial approach to the identification of components that modulate a regenerative response in a target tissue, thereby restoring or partially...
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US20110296538 |
IN VIVO QUANTITATIVE SCREENING TEST FOR ANTI-METASTASIS TREATMENT EFFICACY
The present invention is directed to methods for evaluating the efficacy of a cancer treatment for (i) inhibiting metastasis in a subject, (ii) inhibiting local cancer cell movement, and (iii)...
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US20110236310 |
LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD
The invention provides a labeling composition for an intraocular tissue of a living individual, which specifically labels the intraocular tissue without need of an invasive operation such as...
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US20120100076 |
METHODS OF MODULATING COLD SENSORY PERCEPTION
The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein...
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US20110044895 |
METHODS AND COMPOSITIONS FOR REDUCING STEMNESS IN ONCOGENESIS
The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The...
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US20110286931 |
CARDIAC ARRHYTHMIA TREATMENT METHODS AND BIOLOGICAL PACEMAKER
Disclosed are methods of preventing or treating cardiac arrhythmia. In one embodiment, the methods include administering to an amount of at least one polynucleotide that modulates an electrical...
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US20110150770 |
MULTIVALENT VACCINE AGAINST PORCINE TESCHOVIRUS AND OTHER DISEASE CAUSING ORGANISMS IN SWINE
An immunogenic composition or vaccine, and method of treatment are provided by the present invention. The immunogenic composition is useful for treating, preventing, and lessening the severity of...
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US20110044908 |
Methods and Compositions for Treating and Identifying Compounds to Treat Age-Related Macular Degeneration
The present invention provides methods for treating or limiting development of age-related macular degeneration, as well as methods for identifying compound suitable for such use.
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US20110286930 |
METHODS OF IDENTIFYING MODULATORS OF THE PP2A B56 BETA REGULATORY SUBUNIT
The present invention is based at least in part on the discovery that the PP2A B56 regulatory subunit plays a role in regulating insulin signaling by directly regulating phosphorylation of AKT-I....
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US20110171132 |
Methods, Compounds, and Compositions for Treatment and Prophylaxis in the Respiratory Tract
The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes...
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US20120121513 |
PLATFORM TECHNOLOGIES FOR SPONTANEOUSLY OCCURRING DISEASES
The invention provides platform technologies for spontaneously occurring diseases that can be used for translational medicine. Non-human companion animals, such as dogs, spontaneously develop...
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US20110150772 |
MODULATORS OF CARNITINE OCTANOYLTRANSFERASE IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA
An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea,...
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US20120003158 |
Biomarkers for Inflammatory Bowel Disease and Methods Using the Same
The present invention provides various biomarkers of inflammatory bowel disease, including biomarkers for Crohn's disease and biomarkers for Ulcerative colitis. The present invention also provides...
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US20110293524 |
METHODS AND COMPOSITIONS FOR THE REGULATION OF LECTIN COMPLEMENT PATHWAY (LCP)-ASSOCIATED COMPLEMENT ACTIVATION IN HYPERGLYCEMIC MYOCARDIAL DAMAGE
The present invention relates to methods and compositions for regulating lectin complement pathway (LCP)-associated complement activation. In particular, the invention relates to methods and...
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US20110126299 |
TRIPLE TRANSGENIC MOUSE MODEL OF AUTOIMMUNE DISEASE AND NF-KAPPA B IN VIVO IMAGING
The present invention provides for monitoring of NF-κB-associated inflammation in mice undergoing Id-driven autoimmune disease. The mice are triple transgenic mice expressing both Id+ B cells and ...
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US20110123454 |
Method for modulating appetite
The present invention provides a method of modulating appetite and/or body weight in a subject, said method comprising administering to said subject an effective amount of a MIC-1-modulating agent,...
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US20110038799 |
COMPOSITION FOR TREATMENT AND IMPROVEMENT OF DIABETES COMPRISING CAVEOLIN AS ACTIVE INGREDIENT AND A METHOD FOR TREATMENT OF DIABETES USING IT
The present invention relates to a composition for the treatment and improvement of diabetes comprising caveolin as an active ingredient and a method for treating diabetes using the same, more...
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US20110150773 |
MODULATORS OF ACETYL-COENZYME A ACYLTRANSFERASE 1 OR 2 IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA
An in vitro method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes...
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US20120093730 |
MOLECULAR DEATH TAGS AND METHODS OF THEIR USE
In one embodiment, a death tag for targeting a cell death marker is provided, the death tag comprising a death marker binding domain; a reporter binding domain (RBD); and a reporter component that...
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US20110104065 |
GENETIC ALTERATION ASSOCIATED WITH PRE-MALIGNANT CANCER
Described herein are progenitor cancer cells and cell lines isolated from human breast ductal carcinoma in situ (DCIS) lesions and the uses of these cells or cell lines in drug design, drug...
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