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US20120009125 APOE4 AND APOJ BIOMARKER-BASED PREVENTION AND TREATMENT OF DEMENTIA  
Methods, kits, screens, assays, treatments and treatment regimes for treating a patient at risk for or suffering from dementia, and particularly Alzheimer's dementia which are based upon...
US20110200531 TREATMENT AND DIAGNOSIS OF CENTRAL NERVOUS SYSTEM DISORDERS  
The invention relates to the use of tetramethylpyrazine (TMP) for the treatment of patients at risk for the development of, or diagnosed as having, CNS disorders such as Alzheimer's disease (AD),...
US20140303481 Tissue Disorder Imaging Analysis  
Methods and systems are described for quantitatively determining a score for a patient having a disorder, e.g. a stroke, in a tissue, such as the brain, by analyzing both the extent and location...
US20150110718 METHODS AND KITS FOR DETERMINING A PLACEBO PROFILE IN SUBJECTS FOR CLINICAL TRIALS AND FOR TREATMENT OF PATIENTS  
The present invention is directed to methods and assays for identifying subjects participating in clinical trials that may exhibit a placebo response and identifying treatments for subjects with...
US20130251633 SYSTEMS, METHODS, AND DEVICES FOR ULTRASONIC ASSESSMENT OF CANCER AND RESPONSE TO THERAPY  
Microbubbles can be injected into the bloodstream of a patient, for example, a cancer patient undergoing a treatment specifically targeting a biological process in a tumor. The injected...
US20110217239 SYSTEM AND METHOD OF EVALUATING A PROTEIN OF INTEREST ON TUMOR GROWTH INHIBITION WHILE FOLLOWING THE TUMOR IN VIVO OR IN VITRO  
Disclosed herein are systems and methods for evaluating a protein of interest on growth inhibition of a tumor while following the tumor in vivo or in vitro through a co-expressed visible marker....
US20150071857 STEROID HORMONE AND CHOLESTEROL PATHWAYS AS ONE UNIFIED HOMEOSTATIC SYSTEM  
A unified homeostatic system of cholesterol and steroid hormone pathways is described, in which the uses or modulations of function of the homeostatic system of cholesterol and steroid hormone...
US20110150775 GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS  
The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods...
US20140314674 TREATMENT OF CANCER WITH DIHYDROPYRAZINO-PYRAZINES  
Provided herein are methods for treating or preventing glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) expression and/or promoter methylation status,...
US20110081296 SYSTEMS AND METHODS FOR IDENTIFICATION OF CILIOPATHY THERAPEUTICS  
The invention provides systems and methods for identifying therapeutic targets for treating a disease including a ciliopathy. The invention further provides for drug discovery, and animal model...
US20140212358 NANOPARTICLES FOR THE TREATMENT OF RADIATION SKIN INJURY  
The present invention is associated with a method of evaluating platelet function in vivo using skin-irradiation and nanoparticle radiation treatment. The present invention in the recovery of...
US20110008258 METHODS RELATING TO BREATHING DISORDERS  
Methods for treating breathing disorders by inhibition of the induced PGE2 pathway in a mammalian subject, methods for assessing apnea, hypoxic ischemic encephalopathy or perinatal asphyxia by...
US20120311729 Immunomodulatory Methods and Systems for Treatment and/or Prevention of Atherosclerosis  
Immunostimulatory methods and systems for treating or preventing atherosclerosis and/or a condition associated thereto in an individual.
US20130034500 Cationic Steroid Antimicrobial Compositions and Methods of Use  
The invention provides methods for decreasing or inhibiting herpesviridae (HV) infection or pathogenesis of a cell in vitro, ex vivo or in vivo, a symptom or pathology associated with a...
US20110027184 PROTEIN C PATHWAY ASSOCIATED POLYMORPHISMS AS RESPONSE PREDICTORS TO ACTIVATED PROTEIN C OR PROTEIN C-LIKE COMPOUND ADMINISTRATION  
The invention provides methods, nucleic acids, compositions and kits for predicting a subject's response to treatment with activated protein C or protein C like compound to identify subjects...
US20110195026 PROTEIN  
The present invention provides methods and compositions for the treatment of and for screening, diagnosis and prognosis of colorectal cancer, for monitoring the effectiveness of colorectal cancer...
US20120070379 IMMUNOTHERAPY REGIMES DEPENDENT ON APOE STATUS  
The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
US20110158912 METHOD AND DEVICE FOR DETERMINING THE SEVERITY OF A PAIN DISORDER  
A method for determining the severity of a pain disorder in a subject, comprising the steps of: (i) topically applying an effective amount of menthol or a functional equivalent thereof to the...
US20140348750 HYPERSPECTRAL IMAGING FOR EARLY DETECTION OF ALZHEIMER'S DISEASE  
Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein...
US20110206615 PROBE REAGENT FOR MEASURING OXIDATIVE STRESS  
The present invention relates to fluorescent or luminescent probe reagents for measuring oxidative stress in a cell or an organism. Examples of the probe reagents include: a fluorescent or...
US20100297018 Prognosis and therapy of liver failure  
A method for assessing prognosis in an individual suffering from liver failure, which method comprises detecting endotoxin in the individual, for example by determining the neutrophil function in...
US20140363380 MEX3C REGULATION AND TARGET TO CONTROL OBESITY AND DIABETES  
MEX3C deficiency impairs the development of white and brown adipose tissue. Hence the present invention provides, among other things, a method of screening a candidate compound for activity in...
US20110256063 MEX3C REGULATION AND TARGET TO CONTROL OBESITY AND DIABETES  
MEX3C deficiency impairs the development of white and brown adipose tissue. Hence the present invention provides, among other things, a method of screening a candidate compound for activity in...
US20120087865 TREATMENT OF ISCHEMIA  
A system, including methods and compositions, for treatment of ischemia.
US20120272347 CHITOSAN-ALGINATE SCAFFOLD CELL CULTURE SYSTEM AND RELATED METHODS  
Methods for culturing cancer cells in vitro using a three-dimensional scaffold, scaffolds that include the cultured cancer cells, and methods for using the cultured cancer cells and the scaffolds...
US20120259152 TREATMENT OF HYPOXIC TUMORS WITH LOCALIZED OXYGENATION  
Methods and systems for treatment of hypoxic tumors are provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering an oxygenating agent...
US20130243697 Novel Chimeric Proteins and Methods for Using The Same  
Novel chimeric proteins are disclosed. The proteins comprise at least two portions. The first portion binds to a first cell and decreases the cell's ability to send a trans signal to a second...
US20110150771 CHIMERIC WEST NILE/DENGUE VIRUSES  
The disclosure provides chimeric West Nile/Dengue viruses comprising non-coding regions, non-structural proteins, and a C protein from a West Nile virus and prM and E proteins from a Dengue virus....
US20100143256 ELECTROENCEPHALOGRAPHY BASED SYSTEMS AND METHODS FOR SELECTING THERAPIES AND PREDICTING OUTCOMES  
A method and system for utilizing neurophysiologic information obtained by techniques such as quantitative electroencephalography (QEEG), electrode recordings, MRI in appropriately matching...
US20140086842 SCREENING METHODS USING G-PROTEIN COUPLED RECEPTORS AND RELATED COMPOSITIONS  
The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a...
US20110083200 Method For Testing Efficacy Of Treatment Of Neurologic Disorders  
The method of the invention is useful for evaluating pharmaceutical compositions for treatment of neurological diseases encompassing neurological or neurodegenerative diseases associated with...
US20110280808 Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins  
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and...
US20110256064 Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins  
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and...
US20120087864 METHOD FOR DIAGNOSING AND/OR EVALUATING RETINAL DISEASE  
The present application provides a method for diagnosing and/or evaluating the presence or absence, severity or degree of the improvement of a retinal disease in a subject, which comprises...
US20130259807 CELL CULTURE SCREEN FOR AGENTS THAT CONTROL ADIPOGENESIS AND MYOFIBROBLAST DIFFERENTIATION  
Methods are provided for the rapid and robust screening test agents for adipogenic activity. Agents testing positive in the assays are good candidate agents for wrinkle reduction, normalizing skin...
US20120282184 TREATMENT OF OBESITY  
A method for the prevention or treatment of a condition selected from type 2 diabetes, obesity and metabolic syndrome comprising activating a GITRL pathway. Methods for screening for substances to...
US20100299765 MODALITIES FOR THE TREATMENT OF DEGENERATIVE DISEASES OF THE RETINA  
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
US20140127134 TREATMENT AND PREVENTION OF CANCER WITH HMGB1 ANTAGONISTS  
Embodiments provided herein relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant mesothelioma...
US20100329985 TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES  
The present invention relates to the use of fragments of heat shock proteins for the treatment and/or prevention of autoimmune diseases such as arthritis or inflammatory diseases such as...
US20140348751 Method for Testing and Treating Delayed Food Allergies  
A method for testing, treating, and preventing delayed food allergies includes: receiving detailed symptom, medical, and dietary histories from a patient; formulating a combination of one or more...
US20150037257 COMPOSITIONS AND METHODS FOR HIGH-THROUGHPUT SCREENING IN SKIN FIBROBLASTS WITH AN ALPHA-SYNUCLEIN TRIPLICATION  
Human-derived fibroblast cells with copy number variation for alpha-synuclein, and methods of use thereof, are provided. For example, compositions and methods for high through-put screening of...
US20150250815 INDUCTION OF CHRONIC ELEVATION OF INTRAOCULAR PRESSURE WITH INTRACAMERAL CROSS-LINKING HYDROGEL  
The present invention provides a method for inducing chronic elevation of intraocular pressure in the eyes of an animal by introducing into the eyes a cross-linking hydrogel, an animal produced by...
US20130347137 Stabilized Step Function Opsin Proteins and Methods of Using the Same  
Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to...
US20110150774 SCREENING FOR MODULATORS OF CES1 AND/OR CES3 FOR THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA  
An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with...
US20110150776 Method for Testing and Treating Delayed Food Allergies  
A method for testing, treating, and preventing delayed food allergies includes: receiving detailed symptom, medical, and dietary histories from a patient; formulating a combination of one or more...
US20120301404 TREATMENT OF CACHEXIA  
The invention characterizes and provides a receptor for Proteolysis Inducing Factor (PIF) and associated methods and materials employing the same. These have utility, for example, in the provision...
US20140205540 Method of Improving Balance  
Methods and compositions for modifying an individual's balance time are disclosed.
US20120260355 Method for Evaluating Inhibitory Polynucleotide Efficiency and Efficacy  
The present invention provides a method for testing the efficiency of delivering an inhibitory polynucleotide to a target cell or tissue. The invention also provides a method for testing...
US20120114561 METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS  
Methods for treating neurodegenerative disorders, including Parkinson's disease, are provided. The methods comprise administrating a therapeutically effective amount of oxytocin or oxytocin...
US20130022547 ATTENUATED MYCOPLASMA GALLISEPTICUM STRAINS  
The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated...