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US20090053138 |
Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics
Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination...
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US20090010847 |
Connective Tissue Growth Factor-4
The present invention relates to a novel human protein called Connective Tissue Growth Factor-4, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells,...
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US20080118435 |
COMPOSITION COMPRISING LOW DENSITY MICROSPHERES
Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected...
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US20080107602 |
Neospora caninum isolate
The present invention relates to a novel Neospora caninum isolate from Nowra and extracts thereof. The strain is useful in the development of diagnostic assays for the detection of parasites in...
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US20080102031 |
Spirocyclic Heterocyclic Derivatives And Methods Of Their Use
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic...
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US20080102030 |
PARTICLES FOR CELL TARGETING
Provided is a composition that includes oblate spheroidal particles comprising an active agent, such as a therapeutic or imaging agent, and a method for treating or monitoring a physiological...
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US20080102029 |
Loadable Polymeric Particles For Enhanced Imaging In Clinical Applications And Methods Of Preparing And Using The Same
Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout...
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US20080095714 |
METHOD AND APPARATUS TO IDENTIFY VULNERABLE PLAQUES WITH THERMAL WAVE IMAGING OF HEATED NANOPARTICLES
Provided herein are systems, methods, and compositions for the thermal imaging of cells with nanoparticles.
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US20080095712 |
Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in living organisms
An object of the present invention is to develop a new alternative splicing reporter system and to provide a method for detecting alternative splicing patterns in a multicellular organism more...
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US20080095709 |
Method and apparatus for installation of dental implant
An organ derived from genetic material is inserted in a patient's body. Genetic material is inserted at a selected site in the body to grow an organ.
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US20080095708 |
Biphenyl compounds useful as muscarinic receptor antagonists
This invention provides compounds of formula I:
wherein a, b, c, d, m, n, p, s, t, W, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , and R 8 are as defined in the specification. The compounds of...
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US20080095707 |
CA IX-SPECIFIC INHIBITORS
Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds,...
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US20080095706 |
PEPTIDE PROBES FOR DIAGNOSTICS AND THERAPEUTICS
Disclosed are agents and methods that may be used to diagnose and treat a variety of diseases associated with conformationally-altered proteins. The agents and methods may be used to identify and...
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US20080095705 |
Methods and Devices for Facile Fabrication of Nanoparticles and Their Applications
The invention provides devices and methods to fabricate nanoparticles by reverse micelle method. The method allows to fabricate a myriad of high quality nanoparticles in a repeatable way. These...
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US20080094573 |
SURFACE-MODIFIED MATERIALS, SUCH AS CONTACT LENSES, METHODS AND KITS FOR THEIR PREPARATION, AND USES THEREOF
Modified contact lenses and surfaces, methods for their preparation, and corresponding kits are disclosed. Also disclosed are uses of the contact lenses, such as for the administration of an agent...
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US20080089842 |
Flexibly labeling peptides
A solid phase peptide synthesis method for synthesizing a peptidyl contrast agent is disclosed. In one example, the method includes synthesizing an amino-chelator loaded resin, coupling of the...
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US20080089841 |
Continuous Vessel-Selective Spin Labeling
The invention relates to a method for the MRT representation of a blood vessel (A) and/or of the territory supplied by the blood vessel (A) by labeling the blood, which is guided by this blood...
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US20080089840 |
Bioswellable Sutures
Bioswellable sutures are provided in the form of absorbable, compliant monofilaments of an amphiphilic copolyester, an absorbable multifilament braid, a non-absorbable monofilament with swellable...
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US20080089838 |
Chimeric, Human and Humanized Anti-CSAP Monoclonal Antibodies
The present invention provides humanized, chimeric and human anti-CSAp antibodies and anti-CSAp antibody fusion proteins that are useful for the treatment and diagnosis of various cancers,...
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US20080085242 |
NON-VIRAL GENE DELIVERY SYSTEM
The present invention concerns a novel composition comprising a nucleic acid; and a chitosan containing branching groups covalently linked to the amino groups wherein said branches are selected...
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US20080085241 |
Antibody
The present invention provides the amino acid and nucleic acid sequences of heavy and light chain complementarity determining regions of tumor specific binding proteins. In particular, the present...
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US20080085238 |
Small Molecules for Imaging Protein-Protein Interactions
A tissue is imaged to detect the presence of amyloid deposits or other target proteins prior to their aggregation into plaques, with the assistance of the administration of a labeled bifunctional...
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US20080075667 |
Nanoparticles, nanocapsules and nanogels
Acid-labile poly(N-vinyl formamide) (“PNVF”) nanocapsules were synthesized by free radical polymerization of N-vinyl formamide with optional active ingredients on the surface of silica...
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US20080069774 |
PROTEOMIC ANTISENSE MOLECULAR SHIELD AND TARGETING
The present invention provides compositions and methods for shielding and directing agents to biological targets in cellular systems for therapeutic, prophylactic, and diagnostic uses. Vascular...
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US20080069772 |
Treatment of transformed or infected biological cells
The present invention relates to a therapeutic or/and diagnostic substance. Furthermore it relates to an expression vector, to a composition comprising the afore-mentioned substance or/and the...
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US20080069771 |
Oxygenated polymerized hemoglobin solutions and their uses for tissue visualization
An oxygenated Hemoglobin (Hb) solution includes from about 10 g to about 250 g of polymerized Hb per liter of solution. About 80% by weight, or greater, of the polymerized Hb of the oxygenated...
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US20080063602 |
Magnetic Resonance Imaging Contrast Agents Synthesized Using Ring-Opening Metathesis Polymerization
Polymeric chelating agents and metal chelates, particularly those of lanthanide metals and more specifically those of Gd(III), useful as contrast agents in magnetic resonance imaging (MRI) for...
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US20080063600 |
Diagnostics And Therapeutics For Transmissible Spongiform Encephalopathy And Methods For The Manufacture Of Non-Infective Blood Products And Tissued Derived Products
B-cells have been identified as being the crucial carriers of infectivity in the spread of transmissible spongiform encephalopathy within an infected organism. In a second step, B-cells may infect...
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US20080063598 |
Humanized Antibody
Novel humanized and chimeric antibodies, humanized antibody fragments, polypeptides sequences of such antibodies and derivatives thereof that specifically bind AF-20 are provided as well as methods...
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US20080050311 |
Monoclonal Antibody hPAM4
This invention relates to monovalent and multivalent, monospecific antibodies and to multivalent, multispecific antibodies. One embodiment of these antibodies has one or more identical binding...
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US20080044352 |
COMPOSITIONS AND METHODS FOR LIPOPROTEIN UPTAKE ASSAYS
Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for lipoprotein uptake assays, including high-throughput assays. The disclosed...
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US20080044348 |
Tetanus toxin fragment C based imaging agents and methods, and confocal microscopy dataset processes
Methods for purifying Tetanus Toxin Fragment C comprising obtaining a supernatant comprising soluble Tetanus Toxin Fragment C and purifying Tetanus Toxin Fragment C under native conditions to...
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US20080038197 |
Method and apparatus for representing myocardial tissues in different states of damage
The invention relates to a method for differentially representing myocardial tissue in different states of damage, comprising the following steps: administering a myocardium-suitable contrast agent...
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US20080038196 |
Standardization of botanical products utilizing biological activity as a marker
The present invention relates generally to herbal materials and methods for making such materials in medicinally useful and pharmaceutically acceptable forms. Particularly, the present invention...
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US20080038193 |
Antibodies for use in targeted and temporary treatment of humans and animals
Described is an antibody, or a fragment of an antibody, which binds to an epitope under specifically chosen conditions, and the binding of which to that epitope is broken under specifically chosen...
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US20080031883 |
Condition-dependent, multiple target delivery system
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US20080031822 |
Methods of modeling migraine pain and identifying candidate compounds for the treatment of migraine
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US20080031816 |
Methods and compositions for identifying biomarkers
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US20080031815 |
Pet imaging of vascular endothelial growth factor receptor (VEGFR), compositions for VEGF cancer imaging, and methods of VEGF cancer imaging
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US20080019919 |
Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium
This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an...
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US20080019908 |
Novel amphiphilic substance, and drug delivery system and molecular imaging system using the same
The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery...
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US20080014143 |
Methods and compositions for targeting gC1qR/p32
Disclosed are compositions and methods useful for targeting gC1q/p32 receptors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells, and to areas...
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US20080008651 |
Screening Methods and Transgenic Animals for the Treatment of Beta-Globin Related Disease and Conditions
The orphan nuclear receptors TR2 and TR4 together constitute the DNA binding core of the 540 kDa DRED complex, a putative repressor of the human embryonic ε- and fetal γ-globin genes. Here the...
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US20080008650 |
ENDOMETRIOSIS CELL TARGETING PEPTIDE AND USES THEREOF
Provided herein are compositions and methods for selectively targeting an endometriosis cell.
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