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US20140072510 Synthetic Scaffolds for Metastasis Detection  
Provided herein are synthetic scaffolds engineered to function as a pre-metastatic niche to detect metastasis. In particular, synthetic scaffolds described herein provide detection of the earliest...
US20140363379 NUTRITIONAL APPROACH TO THE USE OF ERGOTHIONEINE AND VITAMIN D2 FOR HAIR, NAIL AND SKIN GROWTH  
Nutritional products, including food and/or beverage compositions, pharmaceutical and cosmetic preparations and methods of use are disclosed for the prevention, suppression and treatment of skin,...
US20110200531 TREATMENT AND DIAGNOSIS OF CENTRAL NERVOUS SYSTEM DISORDERS  
The invention relates to the use of tetramethylpyrazine (TMP) for the treatment of patients at risk for the development of, or diagnosed as having, CNS disorders such as Alzheimer's disease (AD),...
US20110318265 Coupled identification and treatment of cancer  
Provided are methods to treat cancer in which a patient is identified as having gallium-avid cancer by use of a gallium scan or other means, and is then treated with a pharmaceutically acceptable...
US20110054237 Methods and Systems for Magnetic Focusing of Therapeutic, Diagnostic or Prophylactic Agents to Deep Targets  
Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the...
US20140314673 TREATMENT OF CANCER WITH DIHYDROPYRAZINO-PYRAZINES  
Provided herein are methods for treating or preventing head and neck squamous cell carcinoma characterized by deletion of chromosome 11q22 or loss of ataxia telangiectasia mutated expression,...
US20140086838 IDENTIFICATION OF A NEW MOLECULAR FACTOR FOR EARLY DIAGNOSIS OF UROTHELIAL CARCINOMA OF THE BLADDER  
The identification is disclosed of a new molecular factor for the early diagnosis of urothelial carcinoma of the bladder. HtrA1 is a molecule that is produced mainly by the urothelium of the...
US20110177000 Use of S-Nitrosothiol Signaling to Treat Disordered Control of Breathing  
The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem...
US20130243689 MULTI-COMPARTMENTAL MACROPHAGE DELIVERY  
Disclosed are multi-compartmental nanoparticulate systems for imaging as well as the diagnosis, monitoring, and treatment of inflammation and/or disease. These multicompartmental nanoparticulate...
US20100310461 BINDING OF PATHOLOGICAL FORMS OF PROTEINS USING CONJUGATED POLYELECTROLYTES  
A method for treatment of a disease caused by aggregation of misfolded proteins including subjecting a body fluid of a patient to a separation of an aggregated misfolded protein which includes...
US20100297014 METHOD OF DETECTING THE RISK OF CANCER USING GENETIC MARKERS  
An ex vivo method for the detection of the risk of cancer in a patient, comprising the step of: detecting the expression level of one or more gene sequences identified herein in Table 1, or the...
US20100168554 Evaluating Cardiac Function With Dynamic Imaging Techniques and Contrast Media  
Methods suitable for use in diagnostic imaging or to generate a central circulatory turnover (CCT) index for an evaluation of cardiac function of a patient are provided. The resultant CCT index...
US20130017153 UNIT DOSAGE OF APADENOSON  
The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.
US20110200529 ACTIVATABLE BIOLUMINESCENT PROBE SYSTEM AND METHOD OF USE THEREOF  
A method of use of an activatable bioluminescent probe system includes: providing a bioluminescent protein and a quencher in a reaction environment; modifying a ligand between the quencher and the...
US20120087862 ORGAN-SPECIFIC PROTEINS AND METHODS OF THEIR USE  
The present invention relates generally to methods for identifying and using organ-specific proteins and transcripts. The present invention further provides compositions comprising organ-specific...
US20110236314 METHOD OF DETECTION AND DIAGNOSIS OF ORAL AND NASOPHARYNGEAL CANCERS  
The present invention relates to cancer and in particular to oral and nasopharyngeal cancers. In particular, the present invention relates to a method of detection and diagnosis of oral squamous...
US20120251452 APPARATUS AND METHOD FOR IDENTIFYING ONE OR MORE AMYLOID BETA PLAQUES IN A PLURALITY OF DISCRETE OCT RETINAL LAYERS  
The present invention is an apparatus to produce an OCT of an eye or a brain of a patient to identify one or more plaques in a plurality of discrete OCT retinal layers. The present invention also...
US20120177576 OPTICAL DEVICE AND METHOD FOR NON-INVASIVE REAL-TIME TESTING OF BLOOD SUGAR LEVELS  
A device and method for non-invasive real-time testing of blood sugar levels in a diabetic patient. Specifically, this invention is directed to an optical device comprising a contact lens having a...
US20120014868 METHODS TO DIAGNOSE DEGENERATIVE DISC DISEASE  
Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck or back pain so as to improve the diagnosis of...
US20110135573 METALLOPROTEINASE 9 AND METALLOPROTEINASE 2 BINDING PROTEINS  
Proteins that bind to matrix metalloproteinase 9 and to matrix metalloproteinase 2 and methods of using such proteins are described.
US20130156702 METHODS FOR THE TREATMENT AND THE DIAGNOSIS OF CANCER  
The present invention relates to methods for the diagnostic and the staging of cancer such as liver cancer. The present invention also relates to methods for the treatment of cancer including...
US20140186264 EXTRACELLULAR VESICLE-ASSOCIATED PROTEIN MARKERS OF CANCER  
Extracellular vesicle-associated protein biomarkers for use in diagnosing and staging carcinomas, e.g., lung and ovarian cancers.
US20110195026 PROTEIN  
The present invention provides methods and compositions for the treatment of and for screening, diagnosis and prognosis of colorectal cancer, for monitoring the effectiveness of colorectal cancer...
US20110158908 CYCLOSPORIN A-BINDING PROTEIN  
Disclosed are: a composition and a method for the diagnosis and/or the treatment of a CSABP-related disease, the regulation of the proliferation of an RNA virus and the regulation of an...
US20130022545 DRUG DELIVERY SYSTEM FOR TREATMENT OF LIVER CANCER BASED ON INTERVENTIONAL INJECTION OF TEMPERATURE AND pH-SENSITIVE HYDROGEL  
A drug delivery system for the treatment of liver cancer that is based on interventional injection of a temperature and pH-sensitive hydrogel is provided. The drug delivery system is composed of a...
US20150224211 LEUKOCYTES AS DELIVERY CELLS FOR IMAGING AND DISEASE THERAPY  
Theranostic methods are described herein, which are useful in diagnosing and/or treating infection, inflammation, and/or cancer. The methods utilize naturally-occurring leukocytes for in situ...
US20110158912 METHOD AND DEVICE FOR DETERMINING THE SEVERITY OF A PAIN DISORDER  
A method for determining the severity of a pain disorder in a subject, comprising the steps of: (i) topically applying an effective amount of menthol or a functional equivalent thereof to the...
US20120128594 SELECTIVE INFARCTED-TISSUE-TARGETING BACTERIA AND USE THEREOF  
The present invention relates to bacteria which specifically target infracted tissue and use thereof. The present invention provides a selective infracted tissue-targeting bacterium for the first...
US20110150766 Transdermal patch with fatal overdose protection  
A transdermal patch having a top region containing an antagonist followed by a bottom region containing an agonist, whereby the bottommost end of the bottom region is secured to the skin of the...
US20110033386 METHOD OF DETECTING BLADDER CANCER  
Provided is a sensitizing detection agent of an oral or intravenous administration type which enables the detection of bladder cancer with a higher sensitivity without causing pain to the patient....
US20130224114 Translocator Protein Ligands  
The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the...
US20110044898 TRANSLOCATOR PROTEIN LIGANDS  
The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the...
US20120039809 SYSTEMS AND TECHNIQUES FOR MONITORING SUBJECTS  
The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention...
US20110189091 COLON LAVAGE SYSTEM  
The present invention provides compositions, systems, kits, and methods for preparation prior to a colonoscopy or other gastrointestinal procedure. In particular, the present invention provides a...
US20140356283 Probes, Methods of Making Probes, and Methods of Use  
Embodiments of the present disclosure provide for water soluble polyethylene glycol (PEG)-polymeric melanin (PEG-melanin) nanoparticles, methods of using the PEG-melanin nanoparticle, methods of...
US20130230455 USE OF GELSOLIN TO TREAT MULTIPLE SCLEROSIS AND TO DIAGNOSE NEUROLOGIC DISEASES  
The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
US20150017100 ORAL PREPARATION USEFUL IN MEASURING CAPACITY TO METABOLIZE PYRIDINE  
An object of the present invention is to provide an oral preparation that can be used to diagnose the existence or degree of pyridine metabolic capacity disorder, pyrimidine metabolic rate, etc.,...
US20140335021 Ocular Neostigmine Drops for Diagnosing Myasthenia Gravis  
Disclosed is a method for aiding in the diagnosis of myasthenia gravis. Neostigmine, for example one drop of standard intravenous neostigmine solution (2.5 mg/ml) is instilled into each...
US20120189543 Compositions and Methods for Detecting and Treating Implant Loosening and Osteolysis  
Methods and compositions for detecting, diagnosing, and treating osteolysis and implant loosening are disclosed.
US20110243852 METHOD FOR THE PRODUCTION OF LABELLED SCAFFOLDS, COMPRISING AT LEAST ONE REACTIVE FLUORINATED SURFACTANT, AND SCAFFOLD PRODUCED THEREWITH  
The present invention is related to scaffolds for tissue engineering and organ engineering. More particularly, the present invention is related to a method for the production of a labelled...
US20110305633 Methods for Treatment, the Prognostic Assessment and the Detection of Breast Cancer  
The present invention relates to methods for the treatment, the prognostic assessment and the detection of breast cancer.
US20110110859 Protein  
The present invention provides methods and compositions for screening, diagnosis and prognosis of colorectal cancer, for monitoring the effectiveness of colorectal cancer treatment, and for drug...
US20100303723 DRUG DELIVERY SYSTEMS USING FC FRAGMENTS  
The present invention provides drug delivery systems comprising FcRn binding partners (e.g., FcRn binding partner, Fc fragment) associated with a particle or an agent to be delivered. Inventive...
US20110123448 OIL BODY CARRIERS, USES IN TARGET THERAPY AND/OR DETECTION OF THE SAME, AND FUSION PROTEINS COMPRISED THEREIN  
An oil body carrier, its uses in target therapy and/or detection, and a fusion protein comprised therein are provided. The oil body carrier comprises: a) the fusion protein, comprising an oil body...
US20110223104 FLUID BED MEAL CONTAINING A MARKER AND METHODS OF MAKING  
A standardized, edible food containing a label for use in the measurement of gastric emptying by the quantification of marker excreted in the breath of the patient and methods of making the same...
US20120030780 TARGETING OF SALL4 FOR THE TREATMENT AND DIAGNOSIS OF PROLIFERATIVE DISORDERS ASSOCIATED WITH MYELODYSPLASTIC SYNDROME (MDS)  
The present invention discloses nucleic acids, proteins, and antibodies for SALL4 (including isoforms SALL4A, SALL4B, and SALL4C), a zinc finger transcriptional factor. Further, methods are...
US20140219913 Dual Specific Binding Proteins Having a Receptor Sequence  
Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20120076729 METHODS OF TREATING CANCERS  
The present application describes methods for treating and/or preventing cancer or a cancer symptom, e.g., AMPK-related cancers, in a patient in need thereof comprising administering to the...
US20120063997 DELIVERY SYSTEM WITH SCAFFOLDS  
An injectable, agent delivery system comprising a composition comprising: (i) an injectable scaffold material comprising discrete particles, which are capable of interacting to form a scaffold;...
US20110280808 Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins  
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and...