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US20090304776 |
TRANSMUCOSAL DELIVERY OF THERAPEUTIC AGENTS AND METHODS OF USE THEREOF
Described herein is a transmucosal delivery device and their use for delivering bioactive agents across a mucosal membrane. The delivery devices contain a pharmaceutically acceptable oxidizing and...
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US20090304580 |
Anti-Pancreatic Cancer Antibodies
Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The subject antibodies...
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US20090304628 |
STABILIZED PHARMACEUTICAL FORMULATIONS THAT CONTAIN THE INTERFERONS GAMMA AND ALPHA IN SYNERGISTIC PROPORTIONS
The present invention is related to stable pharmaceutical formulations to be applied by parenteral (liquids or freeze-dried), or topic way (gel, unguent or cream) that contain different quantities...
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US20090297573 |
Identifying and Modulating Molecular Pathways that Mediate Nervous System Plasticity
The present invention provides methods for identifying genes and pathways involved in plasticity. The invention applies some of these methods to identify genes that are differentially regulated in...
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US20090297476 |
NOVEL PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION
The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the...
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US20090297475 |
CYSTEINE DIOXYGENASE POLYMORPHISMS
The invention relates to the detection and identification of polymorphisms in cysteine dioxygenase (CDO) for the use of that diagnosis to identify a propensity in a patient towards rheumatoid...
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US20090297471 |
Methods For Autologous Stem Cell Transplantation
Materials and methods for obtaining populations of lymphocytes and administering the population of lymphocytes to a subject are disclosed herein. In particular, disclosed herein are materials and...
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US20090291049 |
Targeted delivery to human diseases and disorders
The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target...
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US20090291062 |
PROTEIN FORMULATIONS AND METHODS OF MAKING SAME
The invention provides an aqueous formulation comprising water and a protein, and methods of making the same. The aqueous formulation of the invention may be a high protein formulation and/or may...
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US20090291144 |
Therapeutic and Prophylactic Compositions Including Catalytic Biomimetic Solids and Methods to Prepare and Use Them
The invention discloses therapeutic and prophylactic compositions based on synthetic solid catalysts such as zeolites, clays, silicates, silicas and double hydroxides. These solids can be used to...
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US20090285771 |
Methods and compositions for needleless delivery of macromolecules
Methods and compositions for needleless delivery of macromolecules to the bloodstream of a subject are provided herein. In one aspect, the invention provides a delivery construct, comprising a...
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US20090285752 |
IMMUNOTHERAPY OF B CELL MALIGNANCIES AND AUTOIMMUNE DISEASES USING UNCONJUGATED ANTIBODIES AND CONJUGATED ANTIBODIES AND ANTIBODY COMBINATIONS AND FUSION PROTEINS
The invention is directed to a method for treating a treating and diagnosing a B cell-related disease, T cell-related disease or an autoimmune disease in a mammal by concurrently or sequentially...
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US20090280164 |
THERAPY FOR HUMAN CANCERS USING CISPLATIN AND OTHER DRUGS OR GENES ENCAPSULATED INTO LIPOSOMES
A method for encapsulating cisplatin and other positively-charged drugs into liposomes having a different lipid composition between their inner and outer membrane bilayers is disclosed. The...
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US20090274656 |
HEPATITIS C VIRUS INHIBITORS
Hepatitis C virus inhibitors are disclosed having the general formula:
wherein R 1 , R 2 , R 3 , R′, B, Y and X are described in the description. Compositions comprising the compounds...
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US20090269303 |
METHOD FOR TREATING OR PREVENTING CONDITIONS BY ELEVATION OF THE ADENOSINE LEVEL IN AN INDIVIDUAL
This invention concerns a method of inducing an elevated level of adenosine in an individual by administering to the individual an effective amount of either i) recombinant protein CD73 or ii) a...
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US20090269305 |
NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
The embodiments provide compounds of the general Formulae I, II, III, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The...
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US20090263354 |
Compositions and siRNAs for inhibiting C/EBPbeta
The invention relates to C/EBPβ and modulation of cell resistance or sensitivity to triggers of cell death. More particular, it provides pharmaceutical compositions and siRNAs for inhibiting...
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US20090257979 |
Novel Inhibitors of Hepatitis C Virus Replication
The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment...
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US20090257980 |
ANTI-VIRUS THERAPY FOR RESPIRATORY DISEASES
The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a...
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US20090246174 |
TREATMENT FOR CUTANEOUS T CELL LYMPHOMA
The present invention provides method for treating a patient with cutaneous T cell lymphoma (CTCL). Generally, the methods include administering to the patient an IRM compound in an amount...
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US20090238789 |
Modified erythropoietin polypeptides and uses thereof
Modified erythropoietin (EPO) polypeptides and other modified therapeutic polypeptides are provided. The EPO polypeptides and other therapeutic polypeptides are modified to exhibit physical...
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US20090238793 |
TOLL LIKE RECEPTOR (TLR) STIMULATION FOR OCULAR ANGIOGENESIS AND MACULAR DEGENERATION
Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of stimulators of the TLR3 and TLR7 receptors, Trif or of IL-10...
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US20090232766 |
Compositions for Inducing Immune Response Comprising Inverted Microsomes
A vaccine composition is provided which comprises inverted microsomes or fragments thereof from an animal cell in association with an externally disposed peptide antigen and a protein of the MHC.
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US20090226508 |
Methods And Materials For Immunization Against Cancer
Disclosed are compositions comprising embryonic stem cells. In some embodiments, the compositions include a plurality of pluripotent cells and one or more pharmaceutically acceptable carriers or...
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US20090220456 |
USES OF INTERFERONS WITH ALTERED SPATIAL STRUCTURE
This invention provides a method for preventing or treating Severe Acute Respiratory Syndrome in a subject comprising administering to the subject an effective amount of recombinant super-compound...
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US20090214424 |
Human glycoprotein hormone superagonists and uses thereof
The present invention provides improved methods of imaging, targeted therapy and detection and diagnostics using modified glycoprotein hormones having increased activity over wild-type hormones.
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US20090214470 |
EYE-DROP VACCINE CONTAINING COPOLYMER 1 FOR THERAPEUTIC IMMUNIZATION
The invention provides an eye-drop vaccine for therapeutic immunization of a mammal comprising Copolymer 1, a Copolymer 1-related peptide, or a Copolymer 1-related polypeptide, for treating...
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US20090208453 |
High pressure treatment of aggregated interferons
High pressure to treat aggregated interferons, particularly recombinant human interferon-β, to reduce the aggregate content of interferon material. Highly pure, soluble monomeric recombinant...
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US20090208451 |
HALOGEN PHOSPHONATE MONOESTERS
The present invention relates to detection, immobilization, and production of proteolytic antibodies using halogen phosphonate monoester probes, immobilizing reagents, and antigen conjugates.
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US20090208450 |
METHOD FOR ENHANCING THE EFFICACY OF ANTIGEN SPECIFIC TUMOR IMMUNOTHERAPY
The invention provides a method for the improved processing efficiency of T cell tumor antigen epitopes using bioinformatic means. The proteolytic sites in the generation of 47 experimentally...
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US20090208452 |
Inhibitor of Endogenous Human Interferon-Gamma
The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-&gammad ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to...
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US20090202480 |
MACROCYCLIC SERINE PROTEASE INHIBITORS
Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also...
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US20090202481 |
Composition for Sustained Release Delivery of Proteins or Peptides
The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a protein or peptide in a controlled manner. The composition of the present...
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US20090196853 |
METHOD OF TREATING HEPATITIS VIRUS INFECTION WITH A MULTIPHASIC INTERFERON DELIVERY PROFILE
The present invention provides methods of treating hepatitis virus infection. The methods generally involve administering a composition comprising an antiviral agent in a dosing regimen that...
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US20090180982 |
VACCINE IMMUNOTHERAPY FOR IMMUNE SUPPRESSED PATIENTS
A method of immunotherapy to treat cancer or a synergistic anti-cancer treatment by administering an effective amount of a natural cytokine mixture (NCM), an effective amount of cyclophosphamide...
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US20090175819 |
MOLECULE AND CHIMERIC MOLECULES THEREOF
The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule that...
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US20090175821 |
Modified therapeutic peptides with extended half-lives in vivo
A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid...
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US20090162319 |
REVERSE TRANSCRIPTASE INHIBITORS
Described herein are novel enzyme inhibitors. In some embodiments, the enzyme inhibitors are reverse transcriptase inhibitors, particularly HIV reverse transcriptase inhibitors. Also described...
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US20090155206 |
Methods, Compositions and Articles of Manufacture for Contributing to the Treatment of Cancers
Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can...
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US20090155208 |
Methods and agents for modulating an immune response
This invention is directed to the targeting of proteins or peptides of interest to an autophagosome, for their presentation on a major histocompatibility complex (MHC) class II molecule and methods...
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US20090148401 |
METHODS AND COMPOSITIONS FOR NEEDLELESS DELIVERY OF BINDING PARTNERS
The present invention relates, in part, to methods and compositions for needleless delivery of macromolecules to a subject. In one aspect, the methods and compositions involve administering to the...
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US20090142300 |
Compositions and methods related to toll-like receptor-3
The invention relates to compositions and methods related to Toll-like receptor (TLR) polypeptides. In some embodiments, the invention relates to managing TLR3 related diseases. In further...
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US20090142301 |
NOVEL PHARMACEUTICAL COMPOSITION OF INTERFERON GAMMA OR PIRFENIDONE WITH MOLECULAR DIAGNOSTICS FOR THE IMPROVED TREATMENT OF INTERSTITIAL LUNG DISEASES
The present invention relates to a novel pharmaceutical composition of compounds having the biological activity of interferon gamma (IFN-γ) or pirfenidone in combination with a diagnostic array of...
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US20090136449 |
Tetracyclic Indole Derivatives as Antiviral Agents
The present invention relates to tetracyclic indole derivatives of formula (I); wherein Ar, D 1 , D 2 , D 3 , D 4 , W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof,...
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US20090130067 |
Cell Population Having Immunoregulatory Activity, Method for Isolation and Uses
The present invention provides a population of connective tissue derived cells that respond to interferon-gamma (IFN-γ) by expressing indolamine-2,3-dioxygenase (IDO) for use in preventing,...
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US20090123367 |
Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases
The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules...
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US20090123420 |
Regulation of T Cell-Mediated Immunity by D Isomers of Inhibitors of Indoleamine-2,3-Dioxygenase
The present invention provides improved treatment methods by the administration of the non-physiologic D-isomer of an IDO inhibitor.
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US20090123413 |
USE OF BAT MONOCLONAL ANTIBODY FOR IMMUNOTHERAPY
The present invention relates to immunotherapy and more specifically concerns the use of immunostimulatory BAT monoclonal antibodies for treatment of a variety of immunodeficiency related diseases...
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US20090104146 |
COMPOSITIONS FOR ENHANCING KERATINOCYTE MIGRATION AND EPIDERMAL REPAIR VIA A RECEPTOR CONTAINING OSMRBETA AS A SUBUNIT, AND APPLICATIONS THEREOF
The present invention relates to the field of epidermal repair. More particularly, the invention concerns the use of a molecule able to activate a heteromeric receptor comprising OSMRβ as a...
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US20090098084 |
PARP INHIBITOR COMPOUNDS, COMPOSITIONS AND METHODS OF USE
The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction...
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