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US20110171315 Oral recombinant helicobacter pylori vaccine and preparing method thereof  
The invention relates to a recombinant protein used for immunoprophylaxis of human Helicobacter pylori infection and a degradable slow-releasing microsphere-encapsulated oral vaccine preparation...
US20110033549 Stabilisation of Proteins  
A dry composition for use in therapy or diagnosis, obtainable by drying an aqueous composition comprising a protein and one or more displacement buffers, wherein the pH of the aqueous composition...
US20150150967 COMPOSITION COMPRISING A COLLOIDAL SYNTHETIC BIORESORBABLE VECTOR AND A VIRAL VECTOR  
A method of vaccination against a viral, bacterial or non-infectious disease includes administering an effective dose of a prime vaccine and then an effective dose of a boost vaccine. Each one of...
US20110033547 DEHYDRATED CHITOSAN NANOPARTICLES  
The present invention relates to dehydrated nanoparticles comprising chitosan and a nucleic acid. Preferably, the nucleic acid is a siRNA. Dehydrated nanoparticles of the invention have improved...
US20120040010 MICROPARTICULATED VACCINES FOR THE ORAL OR NASAL VACCINATION AND BOOSTERING OF ANIMALS INCLUDING FISH  
The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an Immunogenic...
US20110224723 CYANOACRYLATE TISSUE ADHESIVES  
A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including...
US20110293733 SELF-ASSEMBLING NANOPARTICLE DRUG DELIVERY SYSTEM  
A self-assembling nanoparticle drug delivery system for the delivery of drugs including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle...
US20150174153 CHITOSAN HYDROGEL FOR REPAIRING NERVE TISSUE  
The present invention relates to chitosan hydrogel microparticles of a median size d50 comprised between 1 and 500 μm (obtained from a number distribution), the chitosan having a degree of...
US20130273171 ORAL FORMULATION FOR DEXLANSOPRAZOLE  
A stable formulation of dexlansoprazole for treating a digestive disorder, and methods of manufacturing the same.
US20150125384 MODULAR NANODEVICES FOR SMART ADAPTABLE VACCINES  
Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric...
US20110081420 METHOD OF FORMING PROLONGED-RELEASE INJECTABLE STEROIDS  
A method of forming prolonged-release injectable steroids. The method includes providing a steroid composition, a bioabsorbable polymer and a solvent. A solution is formed from the steroid...
US20120064169 MULTIPLE ANTIGEN DELIVERY SYSTEM USING HEPATITIS E VIRUS-LIKE PARTICLE  
This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.
US20150150822 NOVEL CORE-SHELL NANOPARTICLES FOR ORAL DRUG DELIVERY  
The invention relates to an oral nanoparticle drug delivery system, including methods for preparing such a system using a hydrophobic water insoluble protein, which nanoparticles may include...
US20140096284 METHOD FOR THE DELIVERY OF MOLECULES LYOPHILIZED ONTO MICROPARTICLES TO PLANT TISSUES  
The invention provides particles and methods to deliver freeze- or air-dried molecules to cells.
US20140072643 METHODS OF TREATING CANCER  
The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an...
US20110008455 Crosslinked Protein Nanocrystals, Crosslinked Protein Nanoaggregates and Method of Preparation Thereof  
This invention relates to crosslinked protein nanoparticles and a method for producing the same. The method comprises the preparation and nanonization (i.e., size reduction to the nanoscale) of...
US20150030685 Sugar-Free Oral Transmucosal Fentanyl Citrate Lozenge Dosage Forms  
A sugar-free, pharmaceutical composition comprising an oral transmucosal solid dosage form which includes an adherent carrier preblend mixture of a highly potent pharmaceutical agent, and...
US20140065233 INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING  
The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions...
US20130323316 INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING  
The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions...
US20150037426 MODIFIED STARCH MATERIAL OF BIOCOMPATIBLE HEMOSTASIS  
A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a...
US20140010887 MODIFIED STARCH MATERIAL OF BIOCOMPATIBLE HEMOSTASIS  
A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a...
US20110081421 METHODS OF REGULATING RENALASE (MONOAMINE OXIDASE C)  
The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase...
US20140193508 SURFACE BINDING OF NANOPARTICLE BASED DRUG DELIVERY TO TISSUE  
Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as...
US20150216810 CONTROLLED RELEASE HYDROCODONE FORMULATIONS  
A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt...
US20150099004 APREPITANT ORAL LIQUID FORMULATIONS  
A liquid pharmaceutical compositions comprising Aprepitant is preferably prepared as an oral suspension dosage form for the prevention and control of acute and delayed chemotherapy induced nausea...
US20140370111 PROTEIN DELIVERY FROM STEM CELL MICROCARRIERS  
Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.
US20150118319 PROTEOLYSIS-RESISTANT CAPSID OF CHIMERIC HEPATITIS E VIRUS AS AN ORAL DELIVERY VECTOR  
This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.
US20120231086 PROTEIN MATRIX VACCINES OF IMPROVED IMMUNOGENICITY  
The present invention relates to immunogenic compositions containing an antigen of interest entrapped with a crosslinked carrier protein matrix, methods of making such vaccines, and methods of...
US20120294948 VACCINE  
The present invention is concerned with the development of a vaccine against Aeromonas hydrophila for use especially in fish. The invention provides an immunogenic S-layer protein of approximately...
US20110217384 Modified Release Dosage Forms of Skeletal Muscle Relaxants  
A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion...
US20140212503 DELIVERY SYSTEM  
The present invention provides three-dimensional, nanoscale delivery systems, particularly well adapted for delivery of nucleic acids and/or nucleic acid associated entities.
US20110305769 BRANCHED CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM  
The present invention is directed to cationic lipid for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In...
US20110305770 RELEASABLE POLYMERIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM  
The present invention relates to polymer conjugated releasable lipids and nanoparticle compositions containing the same for the delivery of nucleic acids and methods of modulating gene expression...
US20140220149 METHOD FOR PREVENTION AND TREATMENT OF REFLUX INJURY IN THE AERODIGESTIVE TRACT AND LARYNGOPHARYNX CAUSED BY PEPSIN  
A method for treating or preventing disorders, diseases, and symptom of reflux, that is laryngopharyngeal reflux (LPR), in the laryngopharynx caused by pepsin comprises orally administering to the...
US20140099380 Microparticle Formulations for Delivery to the Lower and Central Respiratory Tract and Methods of Manufacture  
Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging...
US20110229581 RELEASABLE CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS  
The present invention is directed to releasable cationic lipids and nanoparticle compositions for the delivery of nucleic acids and methods of modulating an expression of a target gene using the...
US20110008453 Stable Corticosteroid Nanoparticulate Formulations And Methods For The Making And Use Thereof  
Disclosed are stable corticosteroid nanoparticulate formulations, methods of making and therapeutic uses thereof.
US20110064805 Porous cellulose aggregate and molding composition thereof  
A porous cellulose aggregate characterized by having a secondary aggregate structure resulting from aggregation of primary cellulose particles, having a pore volume within a particle of 0.265 to...
US20130337075 NANOMEDICINES FOR EARLY NERVE REPAIR  
The present disclosure describes hydrophobically modified nanoparticles and polymeric nanostructures that can be utilized to for the treatment of neuronal injury or neuronal disease in an affected...
US20140302157 NANOPARTICLE FORMULATIONS AND USES THEROF  
The present invention provides compositions comprising nanoparticles comprising: 1) a drug, such as a hydrophobic drug derivative; and 2) a carrier protein. Also provided are methods of treating...
US20150157566 DRY POWDER FOR INHALATION FORMULATION COMPRISING SALMETEROL XINAFOATE, FLUTICASONE PROPIONATE AND TIOTROPIUM BROMIDE, AND METHOD FOR PREPARING SAME  
Provided is a dry powder for inhalation formulation comprising salmeterol xinafoate, fluticasone propionate and tiotropium bromide, as pharmaceutically active ingredients, and a carrier, and an...
US20130273148 NOROVIRUS VACCINE FORMULATIONS  
The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to...
US20110091565 METHOD OF FORMING NON-IMMUNOGENIC HYDROPHOBIC PROTEIN NANOPARTICLES AND USES THEREFOR  
Methods are described for producing non-immunogenic nanoparticles from protein sources by controlling the pH in a nanoprecipitation process. The nanoparticles that are produced by the disclosed...
US20150231067 METHOD AND COMPOSITION FOR TREATING HYPERGLYCEMIA  
Compositions and methods for treating diseases and or disorders, including hyperglycemia and/or diabetes, and obesity in a subject are provided. In particular, a dry powder oral inhalation system...
US20100297231 PRESERVATION OF BIOACTIVE MATERIALS BY FREEZE DRIED FOAM  
This invention provides methods, systems and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents...
US20140154329 Process For Stabilizing An Adjuvant Containing Vaccine Composition  
The present invention relates to a process for stabilizing an adjuvant containing vaccine composition, an adjuvanted vaccine composition in dry form and in particular a process for stabilizing an...
US20140302158 INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED NICOTIANA TABACUM  
The present invention relates to a composition or composition of bilayer lipid vesicles displaying an influenza virus antigen and carbohydrate, and the production thereof in Nicotiana tabacum...
US20130295190 Systems and Methods for Superdisintegrant-Based Composite Particles for Dispersion and Dissolution of Agents  
The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical...
US20110182998 MICROSPHERES USEFUL FOR THERAPEUTIC VASCULAR EMBOLIZATION  
Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide...
US20130216624 SUSTAINED-RELEASE PELLETS CONTAINING TACROLIMUS AS AN ACTIVE INGREDIENT  
The present invention relates to sustained-release pellets containing tacrolimus as an active ingredient. The sustained-release pellets of the present invention have multiple layers of...