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US20090285897 |
REHYDRATABLE THIOLATED POLYSACCHARIDE PARTICLES AND SPONGE
Tissue and other body structures may be protected using a hydrated composition made from free-flowing rehydratable particles or a rehydratable sponge comprising substantially collagen-free...
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US20090280183 |
MULTIPARTICULATE FORM OF ADMINISTRATION, COMPRISING NUCLEIC ACID-CONTAINING MUCOADHESIVE ACTIVE INGREDIENTS, AND METHOD FOR PRODUCING SAID FORM OF ADMINISTRATION
The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix...
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US20090269407 |
Poly-alpha(1-4)glucopyranose-based matrices with hydrazide crosslinking
The present invention provides biocompatible, biodegradable matrices formed from poly-α(1→4)glucopyranose and reactive hydrazide groups. The matrices can be used for various applications in the...
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US20090258060 |
Hydrogel Compositions
Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic...
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US20090252800 |
Anisotropic nanocomposite hydrogel
Anisotropic nanocomposite hydrogel materials are created using a process in which a hydrogel-forming material is crosslinked in the presence of nanoscale cellulose and subsequently thermally cycled...
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US20090238874 |
BIOMIMETIC COMPOSITION REINFORCED BY A POLYELECTROLYTIC COMPLEX OF HYALURONIC ACID AND CHITOSAN
The present invention relates to a three dimensional, malleable cell culture composition and method of forming the same comprising hyaluronic acid, chitosan and a polyelectrolytic complex of...
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US20090232891 |
Cell Transport Compositions and Uses Thereof
Compositions and methods have been developed for transporting compounds across membranes with little or no toxicity and, when targeted through the appropriate routes of administration (i.e., lung,...
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US20090232857 |
METHOD AND PROCESS FOR THE PRODUCTION OF MULTI-COATED RECOGNITIVE AND RELEASING SYSTEMS
The present invention includes compositions, methods, systems for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural...
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US20090226523 |
DEMINERALIZED BONE MATRIX COMPOSITIONS AND METHODS
Bone matrix compositions and, more specifically, demineralized bone matrix (DBM) having increased osteoinductive capacity and methods for its production are provided. Specifically, DBM derived from...
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US20090226499 |
BIOCOMPATIBLE MATERIALS CONTAINING STABLE COMPLEXES OF TSG-6 AND HYALURONAN AND METHOD OF USING SAME
The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable comples of TNF-stimulated gene protein...
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US20090220608 |
PHARMACEUTICAL COMPOSITION OF MICROSPHERES FOR PREVENTING DIABETIC FOOT AMPUTATION
The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the...
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US20090220605 |
BONE MATRIX COMPOSITIONS HAVING NANOSCALE TEXTURED SURFACES
Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale...
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US20090220596 |
Composition and Dosage Form Comprising a Solid or Semi-Solid Matrix
A composition which comprises a solid or semi-solid matrix having at least one active ingredient uniformly dispersed therein, the matrix comprising at least one pharmaceutically acceptable...
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US20090214654 |
TREATMENT OF ANEURYSM WITH APPLICATION OF CONNECTIVE TISSUE STABILIZATION AGENT IN COMBINATION WITH A DELIVERY VEHICLE
Delivery vehicles for controlled release of connective tissue stabilization agent for the treatment of vascular aneurysms are described. The delivery vehicle generally is combined with a connective...
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US20090214653 |
Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof
The present invention relates to reindeer bone formation inducing protein called bone morphogenetic protein 4 (BMP-4) and nucleotide molecules encoding the proteins and host cells expressing the...
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US20090214604 |
Method of obtaining hydrogels of cyclodextrins with glycidyl ethers, compositions thus obtained and applications thereof
The invention relates to a method of obtaining hydrogels based on (i) cyclodextrins, (ii) cyclodextrins and cellulose ethers or (iii) cyclodextrins and guar gum or the derivatives of same, using...
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US20090203768 |
NUCLEIC ACID-CONTAINING COMPLEX
A nucleic acid-containing complex, containing a nucleic acid and a biodegradable polymer, especially a positively-charged water-insoluble biodegradable polymer, is disclosed. The complex has...
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US20090202642 |
Drug Delivery System Comprising Microparticles and Gelation System
Disclosed are drug delivery compositions comprising a continuous aqueous phase comprising a reverse thermal gelation system comprising a blend of a cellulose derivative and polyethylene glycol; a...
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US20090202641 |
HOLLOW FIBROUS ORGANIC NANOTUBE AND PRODUCTION METHOD THEREOF
Disclosed is a method of synthesizing a water-free nanotube capable of efficiently encapsulating a functional substance therein, in large quantities. The method comprises: dissolving, in an organic...
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US20090202640 |
HYDROGELS OF POLYSACCHARIDE MIXTURES FOR TISSUE ENGINEERING AND AS CARRIERS OF ACTIVE COMPOUNDS
The present invention describes the preparation of hydrogels (or 3D matrices) obtainable from aqueous solutions of mixtures of acid polysaccharides and derivatives of basic polysaccharides, such as...
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US20090202639 |
Biomaterials Consisting of Sulphated Hyaluronic Acid and Gellan to be Used in the Prevention of Spinal Adhesions
New biomaterials consisting of a combination of sulphated hyaluronic acid and gellan (as well as gellan that has not been associated with other polymers), to be used as a highly effective barrier...
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US20090155320 |
Method for producing hydroxyapatite particles
This invention relates generally to a preparation of bone repair compositions, and more special refers to a novel technology in preparing a matrix building polymer i.e. collagen with inclusions of...
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US20090136576 |
Biocompatible composition for replacing/regenerating tissues
A biocompatible composition for replacing/regenerating articular tissues, in particular tissues of the nucleus pulposus but also not articular tissues such as bony tissues, providing a hydrogel...
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US20090117191 |
Controlled release tramadol formulations
A controlled release preparation for oral administration contains tramadol, or a pharmaceutically acceptable salt thereof, as active ingredient.
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US20090117190 |
SUSTAINED-RELEASE PREPARATION
It is intended to provide a sustained-release pharmaceutical preparation with absorbability not dependent on pH. The sustained-release preparation is characterized by containing...
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US20090110735 |
CONTROLLED RELEASE FORMULATIONS
The present invention provides stable, self-assembling, biocompatible and biodegradable hydrogel formulations, into which one or more compounds may be incorporated allowing for delayed release or...
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US20090110719 |
Polyamine modified particles
A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer,...
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US20090104267 |
SOFT TABLET CONTAINING HIGH MOLECULAR WEIGHT CELLULOSICS
The invention relates to an immediate release tablet capable of being chewed or disintegrated in the oral cavity, which comprises a pharmaceutically active ingredient having an optional...
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US20090104266 |
3-(2-DIMETHYLAMINOMETHYLCY CLOHEXYL)PHENOL RETARD FORMULATION
The invention relates to a dosage form for controlled release of the active ingredient 3-(2-dimethylaminomethylcyclohexyl)phenol, preferably (1R,2R)-3-(2-dimethylamino-methylcyclohexyl)phenol, or...
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US20090087490 |
EXTENDED RELEASE FORMULATION AND METHOD OF TREATING ADRENERGIC DYSREGULATION
A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a α 2 -adrenergic receptor agonist; a...
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US20090081296 |
Extracorporeal cell-based therapeutic device and delivery system
Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in...
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US20090081294 |
Sustained release dosage form for lubricating an oral cavity
Aspects of the invention include a sustained release dosage form that can be administered to an oral cavity, e.g., the mouth. In certain embodiments, the sustained release dosage form is formulated...
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US20090061000 |
PHARMACEUTICAL FORMULATION USE 030
An extended release pharmaceutical formulation comprising, as active ingredient, the compound Ph(3-Cl)(5-OCHF 2 )—(R)CH(OH)C(O)—(S)Aze-Pab(OMe) or a pharmaceutically acceptable salt thereof...
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US20090053307 |
IMMEDIATE-RELEASE THERAPEUTIC SYSTEMS FOR IMPROVED ORAL ABSORPTION OF 7-[(E)]-T-BUTY-LOXYMINOMETHYL] CAMPTOTHECIN
A pharmaceutical composition comprising a camptothecin as active ingredient is herein described. In particular immediate-release therapeutic systems are described for the improved oral absorption...
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US20090028946 |
Photo-responsive delivery system
A photo-responsive delivery system useful to deliver a compound to a target site is provided. The system includes a physiologically compatible matrix crosslinked with a photo-responsive matrix...
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US20090022803 |
Oral Formulations For Delivery of Catecholic Butanes Including Ndga Compounds
The present invention provides for compositions, kits and methods for treatment of diseases, where the compositions contain catecholic butanes, including NDGA compounds, such as NDGA derivatives,...
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US20090022801 |
Compositions and Methods for Promoting the Healing of Tissue of Multicellular Organisms
Methods are provided for promoting the healing of tissue of a multicellular organism. The methods can include administering a therapeutically effective amount of a polysulfonated material in a...
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US20090022780 |
HYDROGEL
The invention is related to gel preparations capable of absorbing as well as releasing liquid, and the use of such gel preparations in the treatment of wounds.
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US20090017091 |
STERILE HYALURONIC ACID POLYMER COMPOSITIONS AND RELATED METHODS
The present application provides sterile hyaluronic polymer compositions than are useful, e.g., as medical devices, biomedical adhesives, and sealants. Generally, provided are sterile dry...
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US20090011024 |
Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers
A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous...
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US20090004276 |
Novel injectable chitosan mixtures forming hydrogels
A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about...
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US20090004275 |
Composition for Delivery of an Active Agent
A composition for oromucosal delivery of a biologically active agent, which composition releases the active agent within 5 minutes when applied to an oramucosal surface in use, comprises a...
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US20080317861 |
Polymeric Materials and Methods
Chimeric polymer compositions and methods are provided in which a plurality of carbohydrate moieties and amino acids form the backbone of a polymer. Most preferably, the polymer includes...
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US20080317841 |
Pharmaceutical Composition Containing Coated, Floating Particles
A dosage form exhibiting delayed transit time through the GI tract. The dosage form comprises a plurality of buoyant particles, each comprising an inner drug-containing core, an intermediate layer...
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US20080317818 |
Interpenetrating Networks, and Related Methods and Compositions
The present invention provides interpenetrating polymeric networks (IPNs), and related methods and compositions. The hydrogel material of this invention comprises an interpenetrating network of two...
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US20080311205 |
Abuse resistant drug formulation
A pharmaceutical composition may include a coated particulate which may include at least one active pharmaceutical ingredient, particularly one susceptible to abuse by an individual. The coated...
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US20080311172 |
Programmed-release, nanostructured biological construct
A biologically engineered construct comprising of a polymeric biomatrix, designed with a nanophase texture, and a therapeutic agent for the purpose of tissue regeneration and/or controlled delivery...
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US20080286360 |
Chemically patterned hydrogels, manufacture and use thereof
A chemically patterned modified hydrogel formed from a modified hydrogel is provided. The hydrogel is conjugated with a multiphoton photocleavable molecule. The molecule has a multiphoton-labile...
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US20080286357 |
MULTI-FUNCTIONAL PARTICULATE DELIVERY SYSTEM FOR PHARMACOLOGICALLY ACTIVE INGREDIENTS
The present invention relates to a pharmacologic dosage unit which includes a multi-functional particulate system and a pharmacologically active agent. The multi-functional particulate system...
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US20080279945 |
GEL-BASED DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS
Disclosed are water-soluble gel-based compositions for the delivery of recombinant adeno-associated virus (rAAV) vectors that express nucleic acid segments encoding therapeutic constructs including...
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