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US20090285884 |
Platinum Complexes and Methods of Use
The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to...
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US20090285883 |
Identification of gastrointestinal, pancreatic and cancer stem cell markers and methods of use thereof
DCAMKL-1 has been identified as a biomarker for stem cells, as well as cancer stem cells. Methods of detecting the presence of at least one stem cell, methods of isolating stem cells, and methods...
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US20090285882 |
Stabilized Liposome Compositions and Related Methods of Use
Liposome compositions and related methods of preparation which can comprise one or a plurality of biopolymer components.
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US20090285881 |
CATIONIC LIPIDS AND USES THEREOF
Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
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US20090285880 |
DRIED RECONSTITUTED VESICLE FORMATION FOR PHARMACEUTICAL APPLICATION
The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More...
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US20090285879 |
Malaria prime/boost vaccines
Described are vaccine regimens in which specific prime/boost regimens are applied using low-neutralized recombinant adenoviral vectors harboring nucleic acids encoding antigens from Plasmodium...
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US20090285878 |
Compositions and methods for stabilizing liposomal drug formulations
The present invention is directed to liposomal compositions comprising a camptothecin, which are optimized to reduce camptothecin degradation and/or precipitation of camptothecin degradation...
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US20090285867 |
METHOD FOR EXTEMPORANEOUS AND REVERSIBLE CONCENTRATION OF LIPOSOMES
The invention concerns a method for extemporaneous and reversible concentration of liposomes, the mixed liposome-cyclodextrin aggregates obtainable by the method, and uses thereof in the...
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US20090280168 |
CHLAMYDIA OMP ANTIGEN
The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia ...
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US20090280167 |
ENHANCEMENT OF DRUG THERAPY BY MIRNA
This invention provides methods and compositions for screening of microRNA capable of modulating gene expression in the apoptotic pathway in the presence of HSP90 inhibitor. The use of miRNA for...
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US20090280166 |
FERRITIN AS A THERAPEUTIC TARGET IN ABNORMAL CELLS
Compositions for treatment of iron related diseases comprise an inhibitor of ferritin. An inhibitor of ferritin is active to reduce the level of H ferritin protein in a cell and/or to reduce the...
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US20090280165 |
COMPOUNDS THAT BIND ALPHA5BETA1 INTEGRIN AND METHODS OF USE
The present invention provides biologically active compounds that bind an αsβi integrin. Also included in the present invention are methods for using such biologically active compounds.
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US20090280164 |
THERAPY FOR HUMAN CANCERS USING CISPLATIN AND OTHER DRUGS OR GENES ENCAPSULATED INTO LIPOSOMES
A method for encapsulating cisplatin and other positively-charged drugs into liposomes having a different lipid composition between their inner and outer membrane bilayers is disclosed. The...
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US20090280163 |
High-Efficiency Fusogenic Vesicles, Methods of Producing Them, and Pharmaceutical Compositions Containing Them
The present invention relates to novel fusogenic vesicles as highly efficient and versatile encapsulation systems for delivering a substance of choice, such as nucleic acids, proteins, peptides,...
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US20090280148 |
CASEIN NANOPARTICLE
An object of the present invention to provide: a nanoparticle, which can be produced without the use of surfactants and synthetic polymers, which has a controllable size and is stable in the acidic...
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US20090274754 |
DUAL ACTION, INHALED FORMULATIONS PROVIDING BOTH AN IMMEDIATE AND SUSTAINED RELEASE PROFILE
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations...
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US20090274753 |
PH-SENSITIVE POLYMERIC MICELLES FOR DRUG DELIVERY
Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug...
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US20090274752 |
COSMETIC AND DERMATOLOGICAL FORMULATIONS OF MNTF PEPTIDES
The disclosure is directed to methods and compositions that include MNTF peptides and their analogs for cosmetic and dermatological purposes.
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US20090274751 |
Growth Factor Sensitive Vesicle
A generally spherical growth factor sensitive vesicle bearing growth factor receptors ( 12 ) having chemical compounds ( 14 ) covalently cross-linked to their non-growth factor binding domains. The...
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US20090274750 |
Therapeutic Treatment of Dermatologic Skin Disorders
Willowherb derivatives are incorporated with liposomes in therapeutic compositions for topical application to prevent or alleviate the conditions and symptoms of cosmetic and dermatologic...
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US20090274749 |
Topical Application for Minimizing Melanin Production
Tyrosinase inhibitors are incorporated with liposomes in therapeutic compositions for topical application to hyperpigmentation. In particular, combinations of tyrosinase inhibitors are combined...
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US20090269397 |
TARGETED AND HIGH DENSITY DRUG LOADED POLYMERIC MATERIALS
Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to...
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US20090269396 |
DUAL ACTION, INHALED FORMULATIONS PROVIDING BOTH AN IMMEDIATE AND SUSTAINED RELEASE PROFILE
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations...
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US20090269395 |
USE OF PROTOBERBERINES AS AN ACTIVE SUBSTANCE REGULATING THE PILOSEBACEOUS UNIT
The present invention relates to cosmetic use, by topic application on the skin of at least one protoberberine, with exception of berberine, or a vegetable extract containing it, as an active...
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US20090263474 |
Methods for Treating Autoimmune Diseases in a Subject and In Vitro Diagnostic Assays
The invention provides a method for treating an autoimmune disease in a subject by administering an interferon antagonist and a Flt3 ligand (Flt3L) antagonist. The invention also provides...
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US20090263473 |
Nanoliposome Using Esterified Lecithin And Method For Preparing The Same, And Composition For Preventing Or Treating Skin Diseases Comprising The Same
The present invention relates to a nanoliposome comprising a liposome membrane containing esterified lecithin, and one or more physiologically active ingredients included in inner space of the...
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US20090263472 |
ENDOTHELIN RECEPTOR ANTAGONIST DERIVATIVES
Endothelin receptor antagonist nitroderivatives of general formula (I):
having an improved pharmacological activity compared with their parent compounds. They can be employed for treating or...
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US20090263471 |
Controlled Release Pharmaceutical Composition of Venlafaxine Hydrochloride, and Process for Preparation Thereof
Herein is described a controlled release pharmaceutical composition of venlafaxine hydrochloride, an effective antidepressant, comprising an inert core; on which the active principle is uniformly...
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US20090263470 |
Vaccine Compositions Comprising Virosomes and a Saponin Adjuvant
This invention provides virosome preparations from an enveloped virus, in particular from influenza virus, containing from said virus, and a saponin adjuvant. In particular the invention provides a...
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US20090263469 |
BIGUANIDE-CONTAINING LIPOSOMES
The present invention relates to biguanide-containing liposomes and antiseptic preparations based on biguanide-containing liposomes, where the liposomes are characterised in that they are...
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US20090263327 |
MINIMALLY INVASIVE PHYSIOLOGICAL FUNCTION MONITORING AGENTS
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
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US20090258064 |
COMPOSITIONS OF UCP INHIBITORS, FAS ANTIBODY, A FATTY ACID METABOLISM INHIBITOR AND/OR A GLUCOSE METABOLISM INHIBITOR
Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a...
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US20090252786 |
Use of a Biologically Active Blood Serum for the Treatment of a Disorder Characterized in a Reduced Function of a GABA Receptor
The present invention relates to a method of preventing or treating in a subject a disorder characterized in a reduced GABA receptor function by administering to the subject a therapeutically...
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US20090252785 |
ENDOPLASMIC RETICULUM TARGETING LIPOSOMES
Provided are compositions that include lipid particles, such as liposomes, that can fuse with the ER membrane of a cell. The lipid particles can also deliver a cargo, such as a therapeutic or an...
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US20090252784 |
Compositions comprising inhibitors of RNA binding proteins and methods of producing and using same
Compositions for inhibiting RNA binding proteins, as well as methods of producing and using the same, are disclosed herein.
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US20090252783 |
MEANS FOR INHIBITING THE EXPRESSION OF CD31
The present invention is related to a nucleic acid molecule comprising a double-stranded structure, whereby the double-stranded structure comprises a first strand and a second strand, whereby the...
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US20090246273 |
Ketorolac Sublingual Spray for the Treatment of Pain
The present invention provides for compositions and methods for accelerating the rate of delivery of ketorolac to the systemic circulation by sublingual spray administration under the tongue to...
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US20090246272 |
MDA-7 PROTEINS AND METHODS OF USE THEREOF
This invention provides a method of generating a subtracted cDNA library of a cell comprising: a) generating a cDNA library of the cell; b) isolating double-stranded DNAs from the cDNA library; c)...
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US20090246271 |
Combination of ceramide and gemcitabine for inducing cell death and uses thereof in treating cancer
This invention provides a method for increasing apoptosis in a cancer cell comprising contacting the cancer cell with (a) gemcitabine and (b) C6-ceramide, sequentially or concomitantly, wherein the...
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US20090246270 |
Use of Iontophoresis or Electrotherapy and Ultrasound to Deliver Agents for Skin Rejuvenation.
The method disclosed includes the combining of iontophoresis or electrotherapy and ultrasound to deliver the appropriate chromophores to the skin for cosmetic or therapeutic treatment of the skin...
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US20090246269 |
IDENTIFICATION AND USE OF GPRC VARIANTS IN THE TREATMENT AND DIAGNOSIS OF PARKINSON'S DISEASE
The invention relates genes that are deregulated in Parkinson's disease tissues and the corresponding proteins are identified. These genes and the corresponding proteins are suitable targets for...
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US20090246268 |
LIPOSOMAL, RING-OPENED CAMPTOTHECINS WITH PROLONGED, SITE-SPECIFIC DELIVERY OF ACTIVE DRUG TO SOLID TUMORS
A method for preparing a stable dispersion of a camptothecin, camptothecin prodrug, or analog thereof for administration to a patient in need thereof includes preparing a solution of the...
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US20090246267 |
Carnitine Conjugates of Adamantanamines and Neramexane Derivatives as Dual Prodrugs for Various Uses
This invention concerns compounds of adamantanamines and neramexane, including their pharmaceutically-acceptable salts, diesterioisomers, and formulations for treating Alzheimer's related...
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US20090246256 |
Compositions and Methods for Transmucosal Delivery of Lofexidine
The present invention provides for compositions and methods for accelerating the rate of delivery of lofexidine to the systemic circulation by transmucosal administration through the nasal,...
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US20090246234 |
Therapeutic Treatment Using Niacin for Skin Disorders
Niacin and/or niacinamides are incorporated with liposomes in therapeutic compositions for topical application to prevent or alleviate the conditions and symptoms of skin aging and other...
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US20090246142 |
Triggered Self-Assembly of Nanoparticles In Vivo
The present invention provides triggered self-assembly nanosystems. Such nanosystems comprise a population of triggered self-assembly conjugates, each conjugate comprising one or more monomeric...
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US20090246141 |
HIGHER FATTY ACID TRIESTER AND AMIDE DERIVATIVE HAVING DIETHYLENETRIAMINE-TYPE METAL CHELATE STRUCTURE
A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula...
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US20090238876 |
BISPHOSPHONATES FOR TREATING ENDOMETRIOSIS
A novel method of treating endometriosis is disclosed. The method comprises administering to a female subject in need thereof a therapeutically effective amount of particles comprising an agent...
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US20090238865 |
LIPID NANOCAPSULES, PREPARATION PROCESS AND USE AS MEDICINE
The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially...
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US20090238864 |
DNA VACCINES ENCODING HEAT SHOCK PROTEINS
The present invention is related to a method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a...
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