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US20090297582 |
VASCULAR OCCLUSION DEVICES AND METHODS
A device for in situ treatment of vascular or cerebral aneurysms comprises an occlusion device having a flexible, longitudinally extending elastomeric matrix member that assumes a non-linear shape...
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US20090297581 |
MEDICAL DEVICES HAVING ELECTRODEPOSITED COATINGS
According to one aspect, the present invention provides implantable or insertable medical devices that comprise a conductive substrate and an electrodeposited coating over the substrate. The...
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US20090297580 |
SPINAL NUCLEUS PULPOSUS IMPLANT
The present invention relates to a spinal nucleus pulposus implant for use in the treatment of the intervertebral disc and in particular, to the use of a CD-RAP protein therefore.
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US20090297579 |
Control of Cells and Cell Multipotentiality in Three Dimensional Matrices
Methods for wound healing or tissue regeneration by means of cell and tissue engineering, including using three-dimensional matrices with cells therein. A three-dimensional matrix, optionally...
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US20090297578 |
BIOSOLUBLE COATING COMPRISING ANTI-PROLIFERATIVE AND ANTI-INFLAMMATORY AGENT COMBINATION FOR TREATMENT OF VASCULAR DISORDERS
Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of...
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US20090297577 |
Local Delivery of Apolipoproteins and Their Derivatives
Disclosed are medical devices and methods for the local delivery and treatment of vascular conditions. The methods and treatments involve local delivery of at least one apolipoprotein. The vascular...
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US20090297576 |
Local Delivery of PAR-1 Antagonists to Treat Vascular Complications
Described herein are methods and medical devices used to deliver bioactive agents locally to patients in need of treatment and/or prevention of cardiovascular conditions Local delivery of...
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US20090297575 |
Implantable Drug Delivery Devices Having Alternating Hyrdrophilic And Amphiphilic Polymer Layers
An implantable drug delivery medical device with alternating hydrophilic and amphiphilic polymer layers and methods of using for the treatment of vascular disease are disclosed.
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US20090292359 |
POROUS AND NONPOROUS MATERIALS FOR TISSUE GRAFTING AND REPAIR
“Implants, such as interbody spacers, fusion devices and bone grafts, are provided having improved mechanical properties and/or degradation profiles. Such implants include a three-dimensional...
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US20090291115 |
Superporous hydrogel with cells encapsulated therein and method for producing the same
The present invention is a superporous hydrogel with cells encapsulated within the hydrogel matrix, and a method for producing the same.
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US20090291114 |
OSTEOGENIC COMPOSITION COMPRISING A GROWTH FACTOR/AMPHIPHILIC POLYMER COMPLEX, A SOLUBLE CATION SALT AND AN ORGANIC SUPPORT
The invention relates to an open implant constituted of an osteogenic composition comprising at least:
one osteogenic growth factor/amphiphilic anionic polysaccharide complex, one soluble...
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US20090291113 |
Osteogenic composition comprising a growth factor, a soluble cation salt and organic support
An open implant, and a method for preparing the implant, constituted of an osteogenic composition with at least one osteogenic growth factor, one soluble salt of a cation at least divalent, and one...
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US20090291112 |
Allograft osteochondral plug combined with cartilage particle mixture
An allograft osteochondral plug is combined with a mixture that includes freeze-milled cartilage particles, and such combination is used to repair defects in articular cartilage. The plug includes...
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US20090291111 |
COATING COMPRISING AN AMORPHOUS PRIMER LAYER AND A SEMI-CRYSTALLINE RESERVOIR LAYER
The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods...
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US20090285874 |
Implantable Devices For Accelerated Healing
Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
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US20090285873 |
IMPLANTABLE MEDICAL DEVICES AND COATINGS THEREFOR COMPRISING BLOCK COPOLYMERS OF POLY(ETHYLENE GLYCOL) AND A POLY(LACTIDE-GLYCOLIDE)
The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.
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US20090280156 |
BIOIMPLANT
To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based...
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US20090280155 |
Coating systems for the controlled delivery of hydrophilic bioactive agents
Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a...
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US20090280154 |
Biodegradable Scaffold with ECM Material
We add discontinuous regions of Extra Cellular Matrix (ECM) to a biodegradable scaffold. Hereby it is possible to combine the range of physical properties the scaffold can offer with the...
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US20090280153 |
electrical devices, anti-scarring agents, and therapeutic compositions
Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring agent in order to inhibit scarring that may...
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US20090280152 |
Tropoelastin for Promoting Endothelial Cell Adhesion or Migration
The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cells.
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US20090274741 |
POLYMERS CONTAINING POLY(ESTER AMIDES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME
Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate...
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US20090274740 |
DRUG-LOADED MEDICAL DEVICES AND METHODS FOR MANUFACTURING DRUG-LOADED MEDICAL DEVICES
Drug-loaded medical devices such as stents and methods for manufacturing them are provided. In certain embodiments, the therapeutic agent is loaded only in or on areas of the medical device that do...
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US20090274739 |
METHODS AND COMPOSITIONS FOR TREATING NEOINTIMAL HYPERPLASIA
The present invention relates to compositions containing an mTOR inhibitor, such as rapamycin or a rapamycin derivative, in combination with a PI3 kinase inhibitor and/or a leptin inhibitor,...
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US20090274738 |
IMPLANTABLE DEVICES FOR PROMOTING REENDOTHELIALIZATION AND METHODS OF USE THEREOF
An implantable device for the controlled delivery of an estrogen receptor agonist to an injured site in the lumen of a mammalian blood vessel, wherein the estrogen receptor agonist is present in an...
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US20090269388 |
ALLOGRAFT BONE COMPOSITION HAVING A GELATIN BINDER
The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized...
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US20090269387 |
COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE
Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing...
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US20090269386 |
COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE
Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing...
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US20090269385 |
COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE
Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing...
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US20090269384 |
BIOACTIVE THERMOGELLING POLYMER SYSTEMS AND METHODS OF THEIR USE
Hydrogels comprising poly(N-alkylacrylamide), poly(alkyleneglyco)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water are described, as well as methods of their...
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US20090263464 |
BLADDER RECONSTRUCTION
The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such...
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US20090263452 |
Drug-eluting intravascular prostheses and methods of use
The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis...
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US20090263451 |
Anti-Inflammatory and/or Analgesic Agents for Treatment of Myofascial Pain
Effective treatments of myofascial pain and/or inflammation are provided. Through the administration of an effective amount of at least one anti-inflammatory agent and/or analgesic at or near a...
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US20090263450 |
ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF INFLAMMATORY DISEASES
Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the...
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US20090263449 |
DELIVERY OF NUCLEIC ACID COMPLEXES FROM MATERIALS INCLUDING NEGATIVELY CHARGED GROUPS
Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a medical device including a...
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US20090263448 |
Clonidine Formulation in a Polyorthoester Carrier
Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots...
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US20090263447 |
Crosslinked hyaluronic acid and process for the preparation thereof
The present invention relates to a crosslinked hyaluronic acid that can be obtained according to a process comprising: (a) activation of a hyaluronic acid, (b) reaction of the activated hyaluronic...
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US20090263446 |
METHOD OF MAKING LOAD BEARING HYDROGEL IMPLANTS
Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment...
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US20090263321 |
Compositions and Methods for Treating Post-Operative Pain Using Clonidine and Bupivacaine
Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a...
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US20090259302 |
COATING COMPRISING POLY (ETHYLENE GLYCOL)-POLY (LACTIDE-GLYCOLIDE-CAPROLACTONE) INTERPENETRATING NETWORK
Methods for fabricating coatings for implantable medical devices are disclosed. The method comprises forming a coating on an implantable device comprising an interpenetrating network or...
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US20090258055 |
Heparin Prodrugs and Drug Delivery Stents Formed Therefrom
A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a...
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US20090258054 |
Heparin Prodrugs and Drug Delivery Stents Formed Therefrom
A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a...
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US20090258053 |
MEDICAL STENT PROVIDED WITH A COMBINATION OF MELATONIN AND PACLITAXEL
A stent provided with a composition comprising melatonin and paclitaxel is described. The described stent is useful in treating smooth muscle cell proliferation, such as stenosis and preventing...
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US20090258052 |
COMPOUNDS AND METHODS FOR ALTERING BONE GROWTH
The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include the following:
wherein R 1 and R 2...
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US20090258051 |
Microbes Encapsulated Within Crosslinkable Polymers
The invention relates to porous films comprising crosslinked electrospun hydrogel fibers. Viable microbes are encapsulated within the crosslinked electrospun hydrogel fibers. The crosslinked...
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US20090258050 |
Controlled Drug Delivery Using a Zein Layer Modified with Levulinic Acid
The disclosure relates to medical devices coated with zein admixed with levulinic acid. The medical device may further include a therapeutic agent in contact with zein admixed with levulinic acid....
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US20090258049 |
DRUG ELUTING EXPANDABLE DEVICES
The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which...
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US20090258048 |
Self-Assembling Monomers and Oligomers as Surface-Modifying Endgroups for Polymers
Polymers having the formula R(LE) x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently...
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US20090254191 |
Implant with composite coating
Systems and methods are described for implants with composite coatings to promote tissue in-growth and/or on-growth. An implant includes: a substrate; a structured surface formed on at least a...
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US20090254104 |
METHODS AND COLLAGEN PRODUCTS FOR TISSUE REPAIR
Methods and devices for the repair of articular tissue using collagen material are provided. Compositions of collagen material and related kits are also provided.
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