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US20090304741 |
Yeast-Dendritic Cell Vaccines and Uses Thereof
Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral...
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US20090297551 |
ADJUVANT
This invention relates to a novel adjuvant comprising a transfection reagent, and to uses of this adjuvant. In particular, the adjuvant may be used in compositions for eliciting an immune response...
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US20090297562 |
PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS
The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable...
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US20090285839 |
Antigen uptake receptor for candida albicans on dendritic cells
Dendritic cells (DC) that express the type II C-type lectin DC-SIGN (CD209) are located in the submucosa of tissues, where they mediate HIV-1 entry. Interestingly, the pathogen Candida albicans ,...
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US20090280142 |
METHODS OF DIAGNOSIS AND TREATMENT OF OSTEOPOROSIS
A method of detecting osteoporosis in a mammalian is disclosed herein which includes:
a) obtaining a sample of a bone related tissue or cells; and b) measuring the concentration of at least...
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US20090263376 |
Breaking immunological toterance with a genetically encoded unnatural amino acid
The present invention comprises methods and compositions for producing and/or enhancing an immunological response in a subject against a target moiety such as a disease-related moiety by...
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US20090220517 |
METHOD FOR PRODUCING EPITOMERS AND THEIR USES ON CARRIER MICROORGANISMS
The present invention relates to a method for producing carrier microorganisms, in particular bacteria, which, through targeted genetic manipulation, carry epitopes or epitomers, respectively, on...
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US20090175902 |
Immunogenic Substances Comprising A Polyinosinic Acid-Polycytidilic Acid Based Adjuvant
The present invention provides a polynucleotide adjuvant (PICKCa) composition and methods of use in eliciting an immune response, in particular a mucosal immune response. The polynucleotide...
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US20090169636 |
Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and...
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US20090148389 |
INDUCTION OF MUCOSAL TOLERANCE TO ANTIGENS
Induction of tolerance to antigens by mucosal, preferably oral, delivery of the antigen in combination with an immunomodulating compound producing micro-organism is disclosed. More specifically,...
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US20090148405 |
INDUCTION OF DENDRITIC CELL DEVELOPMENT WITH MACROPHAGE-COLONY STIMULATING FACTOR (M-CSF) RECEPTOR LIGANDS
A method of inducing dendritic cell (DC) development by administering Macrophage-Colony Stimulating Factor Receptor Ligand is provided. M-CSF receptor ligands induce DCs to differentiate into...
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US20090123495 |
Immune Response Inducing Preparations
The present invention provides a pharmaceutical composition with an adjuvant based on an apathogenic virus, together with an antigen. The adjuvant has a natural or through genetical engineering no,...
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US20090081196 |
Medicaments for fungal infections
The protein CAMP65p of C. albicans has been found to be play a significant role in both adhesion and the production of hyphae, which are important factors in both virulence and resistance to...
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US20090047306 |
ADJUVANT COMPOSITIONS
An adjuvant composition comprises a Th1-activating alkaloid, optionally further comprising an auxiliary adjuvant selected from a type 2 adjuvant (e.g. alum and/or MF59), a type 1 adjuvant and/or a...
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US20090041852 |
DRY POWDER COMPOSITIONS AND SYSTEMS FOR POULTRY VACCINATION
This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said...
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US20090017067 |
EMULSION VACCINE COMPOSITIONS COMPRISING ANTIGEN AND ADJUVANT IN THE AQUEOUS PHASE
Emulsion vaccine formulations containing an antigen and an adjuvant in the aqueous phase are used for the vaccination of animals wherein the adjuvant is an acrylic polymer and/or dimethyl...
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US20080292655 |
ENHANCEMENT OF THE IMMUNE RESPONSE FOR VACCINE AND GENE THERAPY APPLICATIONS
Expression cassettes are provided comprising a promoter operably linked to a nucleic acid molecule which, when transcribed in vivo, forms double-stranded RNA that induces the production of...
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US20080241194 |
COMPOSITIONS AND METHODS FOR PROTECTING ORGANS, TISSUE AND CELLS FROM IMMUNE SYSTEM-MEDIATED DAMAGE
This invention concerns novel compositions and methods for for the protection of organs and cells from damage caused by activated lymphocytes, NK-cells and NK-like cells, more particularly...
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US20080233181 |
NANOPARTICLE ADJUVANTS FOR SUB-UNIT VACCINES
The present invention relates to nanoparticle vaccine adjuvants comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens...
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US20080220024 |
ANTIFUNGAL VACCINES WITH SACCHAROMYCES CEREVISIAE
Methods and formulations for vaccinating induce in mammals that are vaccinated protective immunity against diseases caused by fungi. The vaccines include a yeast, such as Saccharomyces cerevisiae...
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US20080220023 |
ANTIFUNGAL VACCINES WITH SACCHAROMYCES CEREVISIAE
Methods and formulations for vaccinating induce in mammals that are vaccinated protective immunity against diseases caused by fungi. The vaccines include a yeast, such as Saccharomyces cerevisiae...
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US20080213306 |
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of...
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US20080199495 |
Stimulation of thymus for vaccination development
The present disclosure provides methods for enhancing the response of a patient's immune system to vaccination. This is accomplished by reactivating the thymus. Optionally, hematopoietic stem...
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US20080181949 |
Nanoemulsion Vaccines
The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion...
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US20080145383 |
Method for Solubilizing Peptide Mixtures
Described is a method for making a pharmaceutical preparation comprising the solubilisation of a peptide mixture, characterized in that the peptide mixture is solubilized by an aqueous solution...
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US20080118530 |
Modulation of Replicative Fitness By Deoptimization of Synonymous Codons
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one...
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US20080107689 |
Stable Microbial Inoculants and Methods for Production of Them
The invention relates to an inoculant in the form of a stable storage paste including a microorganism, a solid carrier, one or more protective substances, and water. The invention further relates...
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US20080085286 |
ASPERGILLUS VACCINE PREPARATION AND METHODS OF MAKING AND USING THEREOF
The present invention relates to compositions and methods in preventing and/or treating diseases caused by Aspergillus . In particular, the present invention is directed to Aspergillus vaccine...
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US20080075743 |
DERMATOCYCOSIS VACCINE
The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to...
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US20080050340 |
CD40 AGONIST ANTIBODY /TYPE 1 INTERFERON SYNERGISTIC ADJUVANT COMBINATION, CONJUGATES CONTAINING AND USE THEREOF AS A THERAPEUTIC TO ENHANCE CELLULAR IMMUNITY
A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or...
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US20080050405 |
Ringworm Vaccine
A ringworm vaccine is disclosed comprising antigen isolated from at least one dermatophyte and a suitable carrier. The “antigen” can include a single antigen from a dermatophyte or a plurality...
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US20080038201 |
GLOBAL REGULATOR OF MORPHOGENESIS AND PATHOGENICITY IN DIMORPHIC FUNGI AND USES THEREOF
A method of screening a compound for anti-fungal properties comprising the steps of exposing a test compound to a fungal histidine kinase, and determining whether kinase activity is inhibited,...
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US20080003239 |
Yeast-based Vaccine for Inducing an Immune Response
The invention provided herein relates to vaccines that can be tailored to achieve a desired immune response. Some compositions provided herein are used for preferentially eliciting a humoral immune...
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