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US20090304747 |
USE OF DMSO AND BOTULINUM TOXIN THERAPY FOR URINARY INCONTINENCE AND RELATED DISORDERS
This disclosure provides a method of treating urologic and related disorders, for example, urinary incontinence, in women through the administration of a composition comprising a neurotoxin and...
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US20090304748 |
CLOSTRIDIAL TOXIN PHARMACEUTICAL COMPOSITIONS
A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient,...
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US20090274729 |
MEDIA FOR CLOSTRIDIUM BACTERIUM AND PROCESSES FOR OBTAINING A CLOSTRIDIAL TOXIN
Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for...
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US20090263426 |
METHODS FOR TREATING HEADACHE
A headache can be treated more effectively by co-administration of a botulinum toxin and a triptan drug to a patient and/or the effectiveness of a triptan medication can be increased. The botulinum...
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US20090252764 |
SUTURE LINE ADMINISTRATION TECHNIQUE USING BOTULINUM TOXIN
The present invention utilizes patient-specific landmarks in order to treat headache pain. In one aspect, the present invention relates to the administration of Clostridial toxins, such as a...
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US20090232849 |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
Compositions and a method for sensitizing a cancer for treatment by cytotoxic therapy is disclosed. The method includes the step of administering to the cancerous tissue or cells a pharmaceutical...
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US20090232850 |
THERAPEUTIC TREATMENTS USING BOTULINUM NEUROTOXIN
Methods for treating a coronary risk factor (such as hypertension, diabetes, hyperlipidemia and obesity) and/or a respiratory disorder (such as asthma, chronic obstructive pulmonary disease and...
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US20090232851 |
SIMULTANEOUS, SEPARATE OR SEQUENTIAL THERAPEUTIC USE OF AT LEAST ONE BOTULINUM NEUROTOXIN AND OF AT LEAST ONE OPIATE DERIVATIVE
The present invention relates to a composition comprising: at least one botulinum neurotoxin, and at least one opiate derivative or its salt. The invention also relates to a product comprising at...
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US20090226468 |
Hybrid tetanus toxoid proteins that migrate retrogradely and transynaptically into the CNS
The non-toxic proteolytic C fragment of tetanus toxin (TTC peptide) has the same ability to bind nerve cells and be retrogradely transported through a synapse as the native toxin. A hybrid protein...
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US20090220568 |
METHODS FOR TREATING A STRICTURE WITH A BOTULINUM TOXIN
Methods of treating a urethral stricture in a patient. The methods can include the step of administering an therapeutically effective amount of a botulinum toxin directly to a urethra of the...
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US20090209937 |
Apparatus and Methods for Treating Epilepsy Using Convection-Enhanced Delivery
Disclosed herein are apparatuses and methods for treating a neurological disorder associated with excessive neuronal excitability (e.g., epilepsy). Methods disclosed herein comprise administering...
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US20090202591 |
LEUCINE-BASED MOTIF AND CLOSTRIDIAL NEUROTOXINS
Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, such as the biological half-life and/or a...
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US20090186052 |
USE OF BOTULINUM TOXIN FOR PORLONGED LOCAL DESENSITIZATION
The invention concerns the use or a fragment of botulinum toxin having said toxin activity for preparing a medicine for reversibly desensitizing an area of the skin, said skin area being designed...
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US20090155314 |
Dermal filler
Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.
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US20090155278 |
Claudins as Markers for Early Detection, Diagnosis, Prognosis and as Targets of Therapy for Breast and Metastatic Brain or Bone Cancer
Methods of diagnosis, prognosis, and treatment of breast cancer, and of metastatic brain cancer, are provided The diagnostic and prognostic methods involve the immunohistochemical detection of the...
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US20090155348 |
Detoxified Recombinant Botulinum Neurotoxin
The present invention relates to the isolation of polypeptides derived from the Clostridium botulinum neurotoxin and the use thereof as immunogens for the production of vaccines and antitoxins,...
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US20090142362 |
Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (CETP)
Improved vaccine compositions and methods of use thereof are described that elicit production of antibodies in an individual to the individual's own endogenous cholesteryl ester transfer protein...
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US20090123498 |
TREATMENT OF POST-STROKE MUSCLE PAIN
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
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US20090117157 |
METHODS OF TREATING UROGENITAL-NEUROLOGICAL DISORDERS USING MODIFIED CLOSTRIDIAL TOXINS
The present specification discloses modified Clostridial toxins, compositions comprising such toxins and methods of treating urogenital-neurological disorders in a mammal using such modified...
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US20090104234 |
METHODS OF TREATING CHRONIC NEUROGENIC INFLAMMATION USING MODIFIED CLOSTRIDIAL TOXINS
The present specification discloses modified Clostridial toxins, compositions comprising such toxins and methods of treating chronic neurogenic inflammation in a mammal using such modified...
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US20090087457 |
Compositions and Methods for Topical Application and Transdermal Delivery of Botulinum Toxins
Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged...
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US20090060953 |
Methods for using tetanus toxin for beneficial purposes in animals (mammals)
Methods of using tetanus toxin to modulate or control neural functions or nonneural cellular activities at selected sites in animals, particularly in mammals, and more particularly in humans, are...
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US20090041806 |
USE OF PRODRUGS OF GABA ANALOGS, ANTISPASTICITY AGENTS, AND PRODRUGS OF GABA B RECEPTOR AGONISTS FOR TREATING SPASTICITY
Methods of treating spasticity by administering a colonically absorbable prodrug of a GABA analog having antispastic activity that is not directly mediated by the GABA B receptor, optionally in...
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US20090028907 |
Botulinum toxin treatment
The invention relates to the use of a liquid or semi-solid formulation of botulinum toxin for the preparation of a medicament intended to treat a disorder characterised by bladder spasms (e.g....
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US20090028908 |
METHODS FOR TREATING NEUROGENIC INFLAMMATION
The present invention relates to methods for treating neurogenic inflammation pain. The methods include administering an effective amount of a composition which includes a botulinum toxin component...
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US20090028906 |
Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin in a solid form
The present invention relates to a method for providing a muscle relaxant at temperatures above 20° C., wherein said muscle relaxant is a solid dry composition comprising the neurotoxic component...
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US20090016988 |
Modified Pore-Forming Protein Toxins and Use Thereof
The present invention provides modified pore-forming protein toxins (MPPTs), capable of being used to kill cancer cells. The MPPTs according to the present invention comprise a modification of the...
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US20090010944 |
OLIGOSIALIC ACID DERIVATIVES, METHODS OF MANUFACTURE, AND IMMUNOLOGICAL USES
The invention relates to methods of producing, and compositions comprising, an isolated alpha (2→8) or (2→9) oligosialic acid derivative bearing a non-reducing end enriched for one or more...
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US20090004225 |
TOXIN COMPOUNDS WITH ENHANCED MEMBRANE TRANSLOCATION CHARACTERISTICS
The present invention relates to a compound comprising a toxin linked to a translocator. Non-limiting examples of toxins of the present invention are botulinum toxin, butyricum toxin, tetani toxins...
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US20080292661 |
Use of Botulinum Toxin for the Preparation of a Medicament for the Treatment of Lithiasis of Salivary Gland, Gall Bladder, Kidney, or Pancreas
The invention relates to the use of a pre-synaptic neuromuscular blocking substance for preparing a medicament intended to treat a gland, organ or duct obstructed by a naturally formed stone. This...
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US20080279895 |
TARGETED DELIVERY OF BOTULINUM TOXIN TO THE SPHENOPALATINE GANGLION
Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are...
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US20080279896 |
Treatment of movement disorders by a combined use of chemodenervating agent and automated movement therapy
The present invention relates to a method of treating a movement disorder in a patient, the method comprising administering a medicament comprising an effective amount of chemodenervating agent to...
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US20080233151 |
Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins
The invention relates to methods for protecting and/or treating a mammal at risk of acquiring a condition associated with bacteria that produce a calmodulin exotoxin, a metalloproteinase exotoxin,...
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US20080220020 |
Transdermal Botulinum Toxin Compositions
Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the...
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US20080220021 |
Topical Botulinum Toxin Compositions for the Treatment of Hyperhidrosis
The use of a topical botulinum toxin composition is disclosed for the treatment of a disorder amenable to treatment by botulinum toxin. The disorder may comprise the symptoms associated with...
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US20080213314 |
COMBINED DNA VACCINE AND BIOLOGICAL MODIFIERS FOR CANCER THERAPY
The present invention relates to the combination of a DNA vaccination strategy that makes use of a nucleic acid encoding an immunogenic polypeptide, with a non-immunosuppressive inducer of tumor...
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US20080213313 |
BOTULINUM TOXIN TREATMENTS
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
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US20080213311 |
CLOSTRIDIAL TOXIN DERIVATIVES AND METHODS FOR TREATING PAIN
Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a...
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US20080213315 |
CLOSTRIDIAL TOXIN PHARMACEUTICAL COMPOSITIONS
A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and...
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US20080213312 |
BOTULINUM TOXIN TREATMENTS
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
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US20080199497 |
Pharmaceutical Composition Comprising Botulinum Toxin for Treating Knee Joint Pain by Saphenous Nerve Entrapment
There is provided a pharmaceutical composition comprising botulinum toxin and a pharmacologically acceptable carrier for treating pain in the knee joint caused by saphenous nerve entrapment. The...
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US20080199498 |
METHODS FOR TREATING EYE DISORDERS
The present invention provides methods of treating an eye disorder. The methods comprise a step of locally administering a Clostridial toxin to the eye of a patient to treat the disorder. The eye...
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US20080181917 |
Methods for therapeutic treatment of carpal tunnel syndrome
A method of treating and/or preventing carpal tunnel syndrome (CTS) is provided, comprising administering a therapeutically effective amount of a botulinum toxin to a patient in need thereof or a...
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US20080171065 |
Methods of Treating Nerve Entrapment Syndromes
Methods of treating nerve entrapment syndromes and/or the pain associated with nerve entrapment syndromes using botulinum type B toxin are disclosed. These methods involve, for example,...
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US20080152672 |
METHODS FOR TREATING GLUTEAL MUSCLE
Methods for treating a buttock deformity or for preventing development of a buttock deformity by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a buttock...
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US20080152667 |
Methods and compounds for the treatment of mucus hypersecretion
A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions involving COPD, comprises administering a...
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US20080138364 |
NEUROPATHIC PAIN TREATMENT METHOD
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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US20080118533 |
Treatment of chronic chalazion and hordeolum with botulinum toxin
Chalazia and hordeola are the most common lesions occurring in the human eyelid, and often recurrences are managed by surgical intervention to remove fatty inclusions within the lid with associated...
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US20080118534 |
THERAPY FOR OBSESSIVE COMPULSIVE HEAD BANGING
Methods for treating a head banging disorder by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration...
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US20080118553 |
Tannate salt form of polypeptide mixtures, their preparation and use
The subject invention provides a composition comprising a mixture of polypeptides in the form of a tannate salt wherein each polypeptide is a copolymer of the amino acids L-glutamic acid,...
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