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US20110293723 SYNTHETIC NANOCARRIER COMBINATION VACCINES  
Disclosed are dosage forms and related methods, that include a first population of synthetic nanocarriers that have one or more first antigens coupled to them, one or more second antigens that are...
US20110280907 METHOD AND SYSTEM FOR BUILDING A PHYLOGENY FROM GENETIC SEQUENCES AND USING THE SAME FOR RECOMMENDATION OF VACCINE STRAIN CANDIDATES FOR THE INFLUENZA VIRUS  
A computer-implemented method and a computer system for identifying a phylogenetic tree from a plurality of biological sequences is provided. Each biological sequence is associated with a sampling...
US20120087944 ORAL VACCINE FAST-DISSOLVING DOSAGE FORM USING STARCH  
A fast-dissolving dosage form (FDDF) for the delivery of a vaccine is prepared using a formulation containing a starch, optionally, along with at least one additional matrix forming agent,...
US20110195091 Avian Influenza Virus Antigen, and Booster Immunization Method for Avian Influenza Vaccine in Combination with Mucosal Adjuvant Which is Effective Through Oral Administration  
When ELISA antibody titer dropped in chickens intramuscularly inoculated with an oil vaccine, recombinant HA and NP antigens prepared using gene recombinant technology were orally administered in...
US20150161359 METHODS FOR SAFETY TESTING  
The invention provides improved methods for the safety testing of compositions which comprise biological products produced in a host cell, such as vaccine antigens or recombinant proteins.
US20110293659 METHOD FOR THE ORAL/MUCOSAL VACCINATION BY MEANS OF RECOMBINANT YEASTS  
Recombinant yeast cells are produced which are used for vaccination, among other uses for the oral vaccination by feeding.
US20130315954 METHOD FOR IMPROVING THE PRODUCTION OF INFLUENZA VIRUSES AND VACCINE SEEDS  
The present invention relates to a method for improving the production of an influenza virus, and in particular influenza vaccine seeds, or a vaccine directed against an influenza virus,...
US20130195917 IMMUNOADJUVANT  
The invention thus relates to a method for boosting the efficiency of a vaccine by co-administering a probiotic bacterium such as L. casei 431 or BB-12 with an influenza vaccine. The invention...
US20120219585 INFLUENZA TREATMENT AND/OR CHARACTERIZATION, HUMAN-ADAPTED HA POLYPEPTIDES; VACCINES  
The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.
US20120076822 INFLUENZA VACCINES WITH REDUCED AMOUNTS OF SQUALENE  
Influenza vaccines include hemagglutinin from at least one influenza A virus strain and at least one influenza B virus strain. They also include an oil-in-water emulsion adjuvant with submicron...
US20130209512 UNIVERSAL INFLUENZA A VACCINES  
Universal flu vaccines are disclosed. The vaccines induce broad and sustained protection against a wide range of influenza A viruses, reduce the need for annual vaccination campaigns with vaccines...
US20130039938 HIGHLY EFFICIENT INFLUENZA MATRIX (M1) PROTEINS  
This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using...
US20110110979 METHOD AND VACCINE FOR OPTIMIZING THE SPECIFIC IMMUNE RESPONSES  
The present invention relates to a method for treating an infection or disease or lesion, in particular an HPV infection. Furthermore, it relates to a vaccine for treating a Human Papillomavirus...
US20140248320 ADJUVANTED INFLUENZA B VIRUS VACCINES FOR PEDIATRIC PRIMING  
The influenza B strain is epidemiologically relevant in the pediatric population. Immunogenic priming of children with influenza B vaccine adjuvanted with an oil-in-water emulsion primes an immune...
US20110059129 AVIAN INFLUENZA VIRUS VACCINE AND A METHOD FOR PREPARING  
The present invention relates to an avian influenza vaccine of plant origin, prepared by transforming a plant with a surface protein of avian influenza virus, hemagglutinin (HA) or neuraminidase...
US20130273120 METHODS AND COMPOSITIONS FOR INTRANASAL DELIVERY  
Provided herein are methods for generating dry vaccine powder formulations. Dry vaccine powder formulations can be used for intranasal delivery. Also provided are methods for stimulating local...
US20110027314 Influenza Vaccines Containing Hemagglutinin and Matrix Proteins  
An immunogenic composition comprising influenza virus haemagglutinin and matrix proteins. These may be from influenza viruses grown in cell culture rather than eggs. The matrix protein may be a...
US20120219605 ADJUVANTED NANOPARTICULATE INFLUENZA VACCINE  
Vaccine compositions comprising influenza antigens formulated as nanoparticulate water in oil miniemulsions. The vaccines may be formulated at the point of use and are useful in emergency response...
US20140004150 Vaccine Injection, Preparation Method and Use Thereof  
The invention provides a vaccine injection, which includes a vaccine and a Traditional Chinese medicinal adjuvant in a mass ratio of 1:0.5-1:10, or a vaccine, a Traditional Chinese medicinal...
US20130189305 METHODS OF PRODUCING INFLENZA VACCINE COMPOSITIONS  
Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
US20110165193 Methods for producing vaccine adjuvants  
An improved method for the manufacture of an oil-in-water emulsion involves three procedures: (i) preparation of a preliminary emulsion; (ii) microfluidization of the preliminary emulsion to...
US20110165192 Methods for producing vaccine adjuvants  
An improved method for the manufacture of an oil-in-water emulsion involves three procedures: (i) preparation of a preliminary emulsion; (ii) microfluidization of the preliminary emulsion to...
US20120141526 Nanoemulsion vaccines  
The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion...
US20140023681 Attenuated Swine Influenza Vaccines and Methods of Making and Use Thereof  
This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof....
US20120244185 IMMUNIZATION STRATEGY TO PREVENT H1N1 INFECTION  
The invention provides chimeric viral expression vectors and method of use for providing an immune response against H1N1 influenza. The compositions of the invention can be used as vaccines for...
US20140079732 COMBINATION VACCINES  
The present invention relates to the field of vaccines. More specifically the present invention relates to compositions and methods for enhancing immune responses induced by vaccines, including...
US20120128717 INFLUENZA VIRUS VACCINE COMPOSITION AND METHODS OF USE  
The present invention is directed to compositions and methods for enhancing the immune response of a human in need of protection against influenza virus (IV) infection by administering in vivo,...
US20110223195 COMPOSITION COMPRISING CHITOSAN FOR OCULAR ADMINISTRATION OF VACCINE(S) TO AVIANS  
The invention relates to vaccine compositions comprising chitosan and a vaccine which are administered to avian species via the ocular route, and methods or programs of vaccination including use...
US20140141042 Expression Systems  
The invention relates to an expression system comprising polynucleotides encoding proteins, wherein the expression system comprises a first polynucleotide encoding at least one protein, peptide or...
US20130273104 Adjuvanted Influenza Vaccines for Pediatric Use  
An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric...
US20120027813 ADJUVANTED INFLUENZA VACCINES FOR PEDIATRIC USE  
An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric...
US20140322297 COMPOSITIONS AND METHODS FOR ENCAPSULATING VACCINES FOR THE ORAL VACCINATION AND BOOSTERING OF FISH AND OTHER ANIMALS  
A composition comprising a drug or pharmaceutically active agent and a bioadhesive delivery system provides for the oral delivery of a vaccine to animals, particularly aquatic animals.
US20110250232 DNA-Transfection System for the Generation of Infectious Influenza Virus  
The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal...
US20140178429 Vaccines Including Antigen From Four Strains of Influenza Virus  
Vaccines of the invention include at least four influenza virus strains. In some embodiments, the vaccines are produced in cell culture rather than in eggs. In some embodiments, the vaccines...
US20110045022 VACCINES INCLUDING ANTIGEN FROM FOUR STRAINS OF INFLUENZA VIRUS  
Vaccines of the invention include at least four influenza virus strains. In some embodiments, the vaccines are produced in cell culture rather than in eggs. In some embodiments, the vaccines...
US20120003277 NANOEMULSION VACCINES  
The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides nanoemulsion compositions harboring one or more...
US20130189304 PRESERVATION OF BIOACTIVE MATERIALS BY FREEZE DRIED FOAM  
This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at...
US20100158943 ADMINISTRATION ROUTES FOR PRIMING/BOOSTING WITH INFLUENZA VACCINES  
Patients receive a mucosal influenza vaccine and then receive a parenteral influenza vaccine, in that order, typically during different visits to a vaccination center.
US20130084307 VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT  
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant...
US20130058997 VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT  
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant...
US20120082697 METHOD FOR PROPHYLAXIS OF INFLUENZA USING VACCINE FOR INTRANASAL ADMINISTRATION  
The present invention provides a vaccine composition for transnasal mucous membrane administration, which contains an influenza virus antigen, polyriboinosinic polyribocytidylic acid (poly (I:C))...
US20130164328 METHODS FOR ENHANCING IMMUNE RESPONSE  
This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (PBT) for relieving tumor-induced suppression of the patient's immune system. The demonstration of...
US20110150940 DRY POWDER COMPOSITIONS AND SYSTEMS FOR POULTRY VACCINATION  
This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said...
US20120207785 PROCESS FOR PREPARING AN INFLUENZA SEED VIRUS FOR VACCINE MANUFACTURE  
The present invention relates to the use of avian cell lines for the preparation of seed influenza vaccines, and to vaccines made therefrom.
US20140234372 NOVEL VLPS DERIVED FROM CELLS THAT DO NOT EXPRESS A VIRAL MATRIX OR CORE PROTEIN  
The present invention discloses novel influenza virus-like particles (VLPs) that contain chimeric proteins or influenza membrane proteins. The chimeric proteins are derived from fragments of...
US20110150925 CELL-BASED SYSTEMS FOR PRODUCING INFLUENZA VACCINES  
The present invention relates to a cell-based method for producing influenza virus vaccines by enriching the population of surface-bound α2,6-sialic acid receptors on a cell surface, such as on a...
US20150250872 VACCINE COMPOSITIONS AND METHODS OF USE  
The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one antigen, wherein the adjuvant is a cationic lipid. The disclosure also provides methods of...
US20110123568 NOVEL USE  
The present invention relates to influenza vaccine formulations and vaccination regimes for immunizing against influenza disease. In particular the invention relates to vaccine formulations...
US20130280297 USE OF TOXOPLASMA GENE PRODUCTS TO PREVENT OR TREAT MICROBIAL INFECTIONS  
The invention provides immunomodulatory proteins, e.g., useful to prevent, inhibit or treat microbial infection.
US20130089570 ORAL VACCINE COMPROMISING AN ANTIGEN AND A TOLL-LIKE RECEPTOR AGONIST  
The present invention provides an immunogenic composition comprising one or more antigens and a Toll-like receptor (TLR) agonist in an orally (e.g. sublingually) administered composition.