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US20090202638 |
BMP GENE AND FUSION PROTEIN
This invention relates to BMP fusion genes, BMP fusion proteins, and methods for making BMP fusion genes and BMP fusion proteins. The invention further relates to methods for treatment using BMP...
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US20080226668 |
Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes
The present invention regards methods and formulations for the treatment of diabetes and the prevention of autoimmune diabetes. The invention includes the administration of human recombinant GAD65...
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US20080118514 |
Neutralizing antibodies and methods of use thereof
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not...
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US20080107686 |
Vaccination with immuno-isolated cells producing an immunomodulator
The present invention relates to immuno-protected encapsulated cells producing an immunomodulator, for example GM-CSF (granulocyte-macrophage colony stimulating factor). The cells of the invention...
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US20080107652 |
Methods and compositions for control of disease in aquaculture
The invention discloses paratransgenesis methods for prevention, amelioration or treatment of a disease or disorder in an aquatic animal. The method comprises providing a genetically modified micro...
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US20080102075 |
PHARMACEUTICAL COMPOSITIONS FOR TREATING ARTHRITIS AND INFLAMMATORY DISEASE
The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage...
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US20080095854 |
DNA DOSAGE FORMS
The present invention relates to DNA formulations suitable for ballistic delivery into the skin of the human body. In particular the present invention provides DNA formulations suitable for...
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US20080095803 |
Protein matrix vaccines and methods of making and administering such vaccines
The invention relates to vaccine compositions having a carrier protein and an antigen of interest entrapped in a complex, methods of making such vaccines, and methods of vaccine administration.
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US20080095788 |
VACCINES
The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an...
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US20080095787 |
ADJUVANTS AND METHODS OF USE
Compositions comprising NKT cell agonist compounds and a physiologically acceptable vehicle are provided. Methods of stimulating an NKT cell and enhancing an immune response are also disclosed....
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US20080095786 |
Compositions And Methods For Preventing And Treating Endotoxin-Related Diseases And Conditions
The invention provides pharmaceutical compositions for preventing and treating endotoxin-related diseases and conditions, as well as methods for making and using such compositions.
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US20080089900 |
Identification of self and non-self antigens implicated in autoimmune disease
The present invention provides isolated peptides relating to the autoimmune diseases pemphigus vulgaris and multiple sclerosis. The peptides relating to pemphigus vulgaris are self epitopes and...
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US20080089899 |
Streptococcus pneumoniae proteins and nucleic
Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.
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US20080085285 |
Use of recombinant heat shock protein complexed to kidney cancer antigen
A heat shock protein in combination with carbonic anhydrase IX and a method for improving immune response to carbonic anhydrase IX in a mammal by complexing it with a heat shock protein prior to...
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US20080085284 |
Construction of a Comparative Database and Identification of Virulence Factors Comparison of Polymorphic Regions in Clinical Isolates of Infectious Organisms
The present invention is directed to novel nucleotide sequences to be used for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of...
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US20080085261 |
Vaccine Adjuvant
The present invention relates, in general, to a method of enhancing an immune response in a mammal and, in particular, to a method of enhancing an immune response to a vaccine comprising...
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US20080075735 |
Demethylated and/or oxidized membrane DNA
A process for the preparation of oxidized and/or demethylated antigens comprising the steps of treating a cell with a stress factor selected from the group consisting of UV-radiation, oxidizing...
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US20080075734 |
Genetic Immunization
Proper timing and combinatorial administration of immunocytokines and Flt3-L combined with vaccination with tumor associated antigens provides an anticancer therapeutic benefit. Sequential...
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US20080069853 |
Antibody production method
A method of inducing the sustained release of antibodies in milk comprising the step of: a) implanting at least one antigen releasing device adjacent to, within close proximity of or within at...
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US20080069833 |
YEAST-BASED VACCINES AS IMMUNOTHERAPY
Compositions and methods for treating and/or preventing a variety of diseases and conditions that are amenable to immunotherapy and, in one particular embodiment, compositions and methods for...
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US20080069828 |
Methods, kits, and antibodies for detecting parathyroid hormone
The present invention relates to novel methods and compositions useful for detecting whole parathyroid hormone at a physiological level and parathyroid fragments in a mammalian sample. Such...
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US20080069827 |
miRNA of HSV-LAT and uses thereof
This invention relates to treatment of Herpes Symplex Virus infection. Specifically, the invention relates to the use of a newly discovered miRNA in the silencing of HSV-LAT gene, which is...
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US20080069826 |
Novel Genes Associated with the Maintenance of Differentiation of Smooth Muscle Cells
A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the...
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US20080069825 |
Multiple CpG oligodeoxynucleotides and their use to induce an immune response
Compositions including multiple oligodeoxynucleotides with a CpG motif are disclosed herein. The compositions can include either D or K type oligodeoxynucleotides. These compositions are of use in...
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US20080069795 |
Amelioration of Drug-Induced Toxicity
Kidney toxicity which is induced by cisplatin and other therapeutic and diagnostic agents, limits the effectiveness of the therapy or diagnosis. Modulation or depletion of T cells ameliorates the...
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US20080069775 |
HUMANIZATION OF AN ANTI-CARCINOEMBRYONIC ANTIGEN ANTI-IDIOTYPE ANTIBODY AS A TUMOR VACCINE AND FOR TARGETING APPLICATIONS
A humanized form of an anti-idiotype antibody to CEA, e.g., hWI2, has conserved immunoreactivity. The clinical benefits of anti-CEA antibodies are maximized by using the humanized anti-idiotype as...
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US20080063654 |
Prostate Cancer Vaccine
Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer. Also...
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US20080057128 |
Biodegradable triblock copolymers, synthesis methods therefore, and hydrogels and biomaterials made there from
A drug delivery system that includes micelles formed from an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a...
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US20080051690 |
Combination Therapy for Preventing or Treating Alzheimer's Disease, and Kit Therefor
The invention relates to a method for preventing or treating Alzheimer's disease (AE). According to said method, a means for inducing a sequestration of amyloid β (Aβ) into a plasma is...
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US20080050402 |
Attenuated influenza NS1 variants
Attenuated influenza virus variants comprising substitutions in NS1 that interfere with viral replication and phosphatidylinositol 3-kinase activation are described. NS1 variant polypeptides,...
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US20080050395 |
METHODS FOR PREPARING AND DELIVERING ADJUVANT COMPOSITIONS
Methods are provided for preparing and delivering an adjuvant for vaccines including lecithin and a polymer. The polymer is preferably polyacrylic acid-based and the delivery method involves...
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US20080050337 |
METHOD FOR USING CALCIUM-SENSITIVE POTASSIUM CHANNEL AGONIST FOR DELIVERING A MEDICANT TO AN ABNORMAL BRAIN REGION AND/OR A MALIGNANT TUMOR
Disclosed are methods of selectively delivering a medicant to an abnormal brain region and/or to a malignant tumor in a mammalian subject, including a human. A medicant is administered...
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US20080044432 |
MAMMALIAN RECEPTOR PROTEINS; RELATED REAGENTS AND METHODS
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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US20080044431 |
THERAPEUTIC FORMULATIONS CONTAINING VENOM OR VENOM ANTI-SERUM EITHER ALONE OR IN COMBINATION FOR THE THERAPEUTIC PROPHYLAXIS AND THERAPY OF NEOPLASMS
A method of treating a mammal prophylactically to prevent neoplastic development comprises administering to the mammal a therapeutic vaccine comprising venom and at least one adjuvant. The method...
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US20080044418 |
Tumor Antigens and Uses Thereof
The invention features tumor antigens; tumor antigen-encoding nucleic acids; antibodies specific for tumor antigens and methods of using the antibodies; methods of identifying tumor antigens and...
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US20080044405 |
Noble metal complex-mediated immunosuppression
Certain noble metal complexes are able to strip peptides from class II MHC proteins, resulting in class II MHC peptides in a peptide-empty conformation that do not support T-cell activation....
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US20080044356 |
Assemblies of Oligomeric Amyloid Beta Protein and Uses Thereof
The present invention provides assemblies of oligomeric amyloid beta protein and uses thereof.
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US20080038361 |
Water-Soluble Nanoparticles Stabilized with Multi-Functional Group Ligands and Method of Preparation Thereof
Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive...
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US20080038356 |
Spray freeze-dried compositions
A process for producing a powder comprises spray freeze-drying an aqueous solution or suspension comprising a pharmaceutical agent, said solution or suspension having a solids content of 20% by...
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US20080038329 |
T-CELL ACTIVATING AGENT
The present invention provides a T cell activator comprising an antigen-bound phospholipid membrane, wherein the phospholipid membrane comprises a phospholipid having an acyl group having one...
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US20080038284 |
Human Immunodeficiency Virus Vaccine
The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to an HLA-based HIV vaccine.
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US20080038283 |
Methods of Evaluating Efficacy of an Immune Response by Assesing Alpha-1 Integrin Expression
Disclosed are compositions and methods evaluating efficacy of an immune response by assessing alpha-1 integrin, screening for, and manufacturing those therapeutic agents. Described herein the...
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US20080031936 |
Immunostimulatory nucleic acid molecules
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US20080026071 |
Microparticles for delivery of heterologous nucleic acids
Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy...
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US20080026006 |
PHARMACEUTICAL COMPOSITION USEFUL FOR VACCINES
A pharmaceutical composition including at least a mixture of at least one oil, at least one surfactant and an aqueous phase, itself including at least one active substance, the pharmaceutical...
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US20080025996 |
Methods and Compositions Comprising Polycationic Compounds
The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
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US20080019993 |
Inhibition of tumour growth
The present invention provides a cytotoxic 7 to 25 mer peptide with three or more cationic residues which has one or more non-genetic bulky and lipophilic amino acids, as well as esters, amides,...
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US20080019989 |
Immunity Adjuvant Containing a Complexed Metal Cation and Vaccine Containing Same
The present invention relates to novel adjuvants for vaccine compositions and said compositions comprising at least one antigen, in particular an antigen of vital, bacterial or parasitic origin and...
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US20080019988 |
Targeting of genetic vaccine vectors
This invention provides methods of obtaining reagents for increasing the specificity of genetic vaccines for a desired target cell or tissue type. The invention also provides delivery vehicles for...
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US20080019968 |
DETECTION, PREVENTION AND TREATMENT OF BREAST CANCER
The invention provides compositions and arrays of glycans for detecting, treating and monitoring breast cancer in a human or other mammal.
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