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US20130022661 BIO-REMODABLE BONE AUGMENTATION DEVICE AND METHOD  
A bio-remodable augmentation device including an implantable member configured for maintaining space in a bone defect. The implantable member is formed from a bio-remodable composite having...
US20120282184 TREATMENT OF OBESITY  
A method for the prevention or treatment of a condition selected from type 2 diabetes, obesity and metabolic syndrome comprising activating a GITRL pathway. Methods for screening for substances to...
US20150125466 METHODS RELATED TO CANCER TREATMENT  
The present invention relates to method for predicting a subject's relative response to cancer immunotherapy treatment. The methods involve providing a sample comprising a tumor cell or a...
US20140086932 METHOD FOR ENHANCING SPECIFIC IMMUNOTHERAPIES IN CANCER TREATMENT  
Methods and compositions of the invention relate to the enhancement of specific immunotherapies in cancer treatment. In particular, aspects of the invention relate to novel approaches to boost...
US20050037004 Treatment of chronic joint inflammation  
Use of an aglycosylated antibody having a binding affinity for the CD3 antigen complex is provided for the manufacture of a medicament for treatment of chronic joint inflammation, and more...
US20110142846 METHOD FOR DIAGNOSING AND TREATING EMPHYSEMA  
The present invention provides methods for diagnosing a patient with emphysema or COPD by detecting the levels of EMAP II in a sample. Alternatively, methods are provided for determining the...
US20150246119 METHODS FOR TREATING OR PREVENTING ASTHMA BY ADMINISTERING AN IL-4R ANTAGONIST  
The invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods featured in the invention comprise administering to a subject in need thereof a...
US20090169550 THERAPY OF RITUXIMAB-REFRACTORY RHEUMATOID ARTHRITIS PATIENTS  
A method is disclosed of treating a rituximab-refractory rheumatoid arthritis (RA) patient comprising administering an anti-CD20 antibody other than rituximab to the patient in an amount effective...
US20130336961 B Cell Depletion for Central Nervous System Injuries and Methods and Uses Thereof  
Therapeutic B lymphocyte (B cell) depleting antibodies and methods and uses thereof in the treatment of patients having central nervous system injuries are described.
US20130078238 Methods and Compositions for Treating Hepatitis with Anti-CD3 Immune Molecule Therapy  
A method or composition comprising an anti-CD3 immune molecule for treatment of hepatitis in a subject.
US20120107233 Cytotoxicity Mediation of Cells Evidencing Surface Expression of CD44  
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease...
US20110280869 METHODS OF PREVENTING OR TREATING INFLAMMATORY OR AUTOIMMUNE DISORDERS BY ADMINISTERING CD2 ANTAGONISTS IN COMBINATION WITH OTHER PROPHYLACTIC OR THERAPEUTIC AGENTS  
The present invention provides to methods of preventing, treating or ameliorating an autoimmune or inflammatory disorder or one or more symptoms thereof utilizing combinatorial therapy. In...
US20150064197 METHODS OF MODULATING IMMUNITY  
The invention provides novel methods of administering anti-CD3 antibodies, e.g., via oral or mucosal delivery. The invention also provides methods of treating, preventing, or delaying the onset of...
US20070184050 Stable water-based medicinal preparation containing antibody  
A stable liquid medical formulation containing an antibody is provided, which contains a therapeutically effective amount of an antibody in a glutamate buffer and/or a citrate buffer and has a pH...
US20140023648 Treatment of Osteoarthritis Using IL-20 Antagonists  
Methods for alleviating or delaying the onset of osteoarthritis in a subject in need of the treatment using an IL-20 antagonist, which can be an antibody that blocks a signaling pathway mediated...
US20140314785 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY  
The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of...
US20130142807 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY  
The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of...
US20110097325 Modulation of T cell Differentiation for the treatment of T helper cell mediated diseases  
The present invention relates to methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to...
US20100285106 MULTICOMPONENT VACCINE  
The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a multicomponent vaccine and method of using same to protect against HTV-I infection.
US20150190506 COMBINATION THERAPY COMPRISING OX40 BINDING AGONISTS AND PD-1 AXIS BINDING ANTAGONISTS  
The invention provides compositions and methods for treating cancers. The method comprises administering a PD-1 axis binding antagonist and an OX40 binding agonist.
US20130323239 MODULATION OF PILR RECEPTORS TO TREAT SEPSIS  
The present invention provides methods of using agonists and antagonists of PILRα and PILRβ, respectively, to treat immune mediated sepsis. Also provided are methods of prophylactically treating...
US20060057107 Combination treatment for multiple sclerosis  
The present invention provides for the treatment of multiple sclerosis by combination therapies of CD52 specific antibodies, such as CAMPATH-1H, with either a Type 1 interferon or coploymer-1.
US20120039903 METHODS FOR SUPPRESSING AN IMMUNE RESPONSE OR TREATING A PROLIFERATIVE DISORDER  
Disclosed herein are methods for suppressing an immune response in a subject, treating a neoplasm in a subject, or treating a fibroproliferative vascular disease in a subject, that includes...
US20120148676 ARTIFICIAL CELL CONSTRUCTS FOR CELLULAR MANIPULATION  
The present invention contemplates induction of immunological tolerance thereby providing permanent allogcaft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive...
US20140294853 ANTAGONISTIC DR3 LIGANDS  
The present invention relates to treatment of inflammatory diseases. In particular, the present invention relates to antagonistic DR3 ligands useful for treating inflammatory diseases.
US20050058641 Tolerance induction and maintenance in hematopoietic stem cell allografts  
Provided are methods and compositions for the induction and maintenance of tolerance in hematopoietic stem cell allografts.
US20110177088 Method for Treating and Diagnosing Hematologic Malignancies  
The invention relates to methods for treating and diagnosing hematologic malignancies, Chronic lymphocytic leukemia and Small Lymphocytic Lymphoma in particular, using PD-1 ligands (PD-L1, PD-L2...
US20060263358 Method for reducing sepsis or cardiogenic shock associated with myocardial injury  
Methods of reducing sepsis or cardiogenic shock in patients experiencing myocardial injury are described. More specifically, this disclosure relates to the administration of a C5-C9 terminal...
US20070190053 Treament of lupus nephritis with anti-CD40L compounds  
This invention relates to methods for treatment of nephritis associated with immune complex disease using anti-CD40L compounds. According to one embodiment of this invention, anti-CD40L compounds...
US20070141053 Treatment of inflammatory respiratory diseases  
The present invention relates to the use of immune modulatory factors which act at CD114, CD116, and or CDw131 to successfully treat various forms of inflammatory respiratory disease, including,...
US20110076277 METHODS OF IDENTIFYING ANTI-INFLAMMATORY COMPOUNDS  
A mammalian C-type lectin receptor type is identified which is shown to bind IgG antibodies or Fc fragments, thus inducing IVIG-related reversal of inflammation associated with various immune...
US20050186206 Detection of CD20 in therapy of autoimmune diseases  
The present invention concerns therapy of autoimmune diseases where CD20 is detected in a sample from a patient.
US20150239972 METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
US20130011395 METHODS AND COMPOSITIONS FOR TREATING AUTOIMMUNE DISEASES OR CONDITIONS  
The present invention relates to methods of treating immune disorders, particularly autoimmune and inflammatory disorders such as rheumatoid arthritis, and methods of producing antibodies for use...
US20110250200 SOLUBLE LYMPHOTOXIN-BETA RECEPTOR FUSION PROTEIN AND METHODS FOR INHIBITING LYMPHOTOXIN BETA-RECEPTOR SIGNALING  
This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are...
US20110038855 TRAIL AND METHODS OF MODULATING T CELL ACTIVITY AND ADAPTIVE IMMUNE RESPONSES USING TRAIL  
Methods of modulating a T cell response are provided. Methods include, among other things, contacting a T cell that expresses TNF-related apoptosis-inducing ligand (TRAIL, Apo-2L) or TRAIL...
US20120076753 USE OF NKP46 FOR PREVENTING DIABETES  
The invention relates to use of the natural cytotoxicity receptor NKp46 for preventing and treating diabetes, including type I diabetes (TID) and type 2 diabetes. In particular, the invention...
US20150110779 METHODS FOR PREDICTING GASTROINTESTINAL IMMUNE-RELATED ADVERSE EVENTS (GI-IRAE) IN PATIENTS TREATED WITH MODULATION OF THE CO-STIMULATORY PATHWAY  
The invention described herein relates to diagnostic and therapeutic methods and compositions useful for predicting the likelihood a cancer patient will experience a gastrointestinal...
US20140248278 ANTI-CD22 ANTIGEN BINDING MOLECULES TO TREAT LUNG CANCER AND PROSTATE CANCER  
This invention provides methods for preventing, reducing, delaying or inhibiting the proliferation and/or growth and/or metastasis of lung cancers and prostate cancer that express or overexpress...
US20070134312 Liposomes for treatment of multiple myeloma  
A method for treating multiple myeloma in newly diagnosed or previously treated patients is described. The method comprises administering a composition consisting of a combination of...
US20120225069 USE OF A COMPOUND FOR REDUCING THE BIOLOGICAL EFFECTIVENESS OF IL-6  
Use of a compound comprising at least a structural entity which binds or is an antagonist for interleukin-6 (IL-6) and/or the IL-6 receptor or parts of it, preferably human IL-6 which compound...
US20140234400 Targeted Lipid-Drug Formulations for Delivery of Drugs to Myeloid and Lymphoid Immune Cells  
A method of preferentially delivering an active agent to an immune cell, such as a myeloid progenitor cell, a dendritic cell, a monocyte, a macrophage or a T-lymphocyte, or other cell type...
US20050191297 Detection of CD20 in transplant rejection  
The present application describes a method of treating transplant rejection in a patient, where CD20 is detected in a sample therefrom.
US20150259427 GITR BINDING MOLECULES AND USES THEREFOR  
The present invention provides binding molecules that specifically bind to GITR, e.g., human GITR (hGITR), on T cells and dendritic cells. Binding molecules of the invention are characterized by...
US20120207763 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES  
The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrrolopyrimidine compounds and derivatives are...
US20080014174 Method for treating tumors, infectious diseases, and autoimmune diseases with an activated HLA matching donor-originating lymphocyte  
According to the present invention, HLA matching donor-originating activated lymphocytes highly effective in the treatment of patients with tumors, viral infections and autoimmune diseases are...
US20050112122 Generation of hematopoietic chimerism and induction of central tolerance  
The invention relates to the methods for producing hematopoietic chimerism and central tolerance by peripheral tolerance induction without myeloablative conditioning.
US20060228333 Methods for control of tumors and chronic infections by modulating immunologically informed carriers homing to tolerogenic organs or tissues  
Methods for treating a patient after transplantation of a liver are presented which facilitate acceptance of the donor liver and treat the underlying disease or disorder that led to the...
US20110300142 USE OF ZEBURALINE FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR IMMUNE REJECTION OF TRANSPLANTS  
The invention relates to the use of 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one derivative or mimetic or an analogue, derivatives, metabolites, variants or salts thereof for the manufacturing...
US20080118515 Regulatory T-Cells Containing Galectins for the Therapy and Diagnosis of Diseases  
The invention relates to regulator T-cells containing galectins, in particular, the use thereof as markers and for the therapy and diagnosis of diseases, in particular, of allergies and autoimmune...
Matches 1 - 50 out of 397 1 2 3 4 5 6 7 8 >