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US20130302320 Use of Semaphorin-4D Binding Molecules to Promote Neurogenesis Following Stroke  
Provided herein are methods for promoting neurogenesis in neural tissue of a patient exhibiting at least one symptom of a central nervous system disorder, the method comprising administering to a...
US20110158993 Train-R: A Cysteine Rich Member of the TNF-Receptor Family  
Novel receptor in the TNF family: TRAIN-receptor.
US20120201821 Treatment of Gastrointestinal Inflammation and Psoriasis and Asthma  
The present invention provides methods and means to reduce gastrointestinal inflammation. In particular, the invention provides methods and means to treat inflammatory bowel disease (IBD) and...
US20140341926 METHOD FOR EGFR DIRECTED COMBINATION TREATMENT OF CANCER  
The present invention relates to a method of treating patients suffering from cancers driven by deregulated Human Epidermal Growth Factor Receptor (HER/Human EGFR), wherein an irreversible...
US20120141471 Methods of Inhibiting Metastasis from Cancer  
The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or...
US20130115206 Compositions and Methods for Treating and Diagnosing Cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
US20130216540 MODULATION OF THE INNATE IMMUNE SYSTEM THROUGH THE TREM-LIKE TRANSCRIPT 2 PROTEIN  
TREM-like transcript 2 (TLT2), is expressed on neutrophils, macrophages, and B lymphocytes. Expression of TLT2 is up-regulated on neutrophils and macrophages in response to inflammatory stimuli in...
US20130224214 Compositions and Methods for Therapy and Diagnosis of Cancer and Cancer Metastasis  
The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer....
US20140127134 TREATMENT AND PREVENTION OF CANCER WITH HMGB1 ANTAGONISTS  
Embodiments provided herein relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant mesothelioma...
US20150212088 COMPOSITIONS AND METHODS FOR DETECTING AND TREATING COLORECTAL CANCER  
The present invention relates to compositions and methods for the detecting, treating, and empirically investigating the interaction between a subject's immune system and cancer stem cells. In...
US20150044135 DUAL FUNCTION MARKERS FOR DIAGNOSTICS AND THERAPEUTICS FOR UPPER GASTROINTESTINAL TRACT PRECANCER  
The invention described herein relates to the detection, diagnosis, and treatment of intestinal metaplasias that develop to esophageal, gastric, and pancreatic adenocarcinoma. The stem cells and...
US20140328904 GLA MONOTHERAPY FOR USE IN CANCER TREATMENT  
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen.
US20140314834 GLA MONOTHERAPY FOR USE IN CANCER TREATMENT  
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen.
US20110142756 Method And Composition For The Treatment Of Cancer By The Enzymatic Conversion Of Soluble Radioactive Toxic Precipitates In The Cancer  
The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called...
US20110027173 EPHRIN TYPE-A RECEPTOR 10 PROTEIN  
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer,...
US20110064737 ErbB ANTAGONISTS FOR PAIN THERAPY  
The present application describes the use of ErbB antagonist, especially ErbB2 antibodies such as rhuMAb 2C4, for treating pain.
US20130108643 METHOD TO TREAT AUTOIMMUNE DEMYELINATING DISEASES AND OTHER AUTOIMMUNE OR INFLAMMATORY DISEASES  
The invention relates to methods of preventing or inhibiting the onset and/or treating autoimmune demyelinating neuropathy and other autoimmune or inflammatory diseases involving macrophage...
US20140248211 METHOD OF TREATING CANCER  
The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and...
US20120029473 USE OF 5C8 MAB AND DIRECT INDUCTION OF REGULATORY CD8+ T CELLS TO ESTABLISH PERMANENT AND SPECIFIC TRANSPLANTATION TOLERANCE  
A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term...
US20100316640 POLYSACCHARIDE COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT AND PREVENTION OF DISORDERS ASSOCIATED WITH PROGENITOR CELL MOBILIZATION  
Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
US20130195880 Identification of Polymorphisms and Their Use as Markers for Disease Susceptibility, Diagnosis and Treatment Optimization  
Provided are methods and kits to determine whether a subject is predisposed to developing a disease or condition associated with structural polymorphisms in genes CNTNAP2 and CNTNAP4, along with...
US20130084281 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, TUMORS, AND TUMOR-RELATED DISORDERS  
Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.
US20110091452 4,5-Dihydromacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies  
The present invention relates to 4,5-dihydromacbecin analogues to the formula (IA) or (IB), or a pharmaceutically acceptable salt there of: wherein: R1 represents H or CONH2 that are useful, e.g....
US20110104256 METHODS FOR TREATING OR PREVENTING COLORECTAL CANCER  
The present invention provides, for example, methods for treating or preventing colorectal cancer with an anti-IGF1R antibody in association with sunitinib or a combination of leucovorin and...
US20120128673 MODULATION OF PILR RECEPTORS TO TREAT MICROBIAL INFECTIONS  
The present invention provides methods of using agonists and antagonists of PILRα and PILRβ, respectively, to treat S. aureus infection, in particular, S. aureus infections of the lungs. Also...
US20150132315 METHODS TO IMPAIR HEMATOLOGIC CANCER PROGENITOR CELLS AND COMPOUNDS RELATED THERETO  
Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous...
US20130164215 COMPOSITIONS AND METHODS FOR DETECTING, DIAGNOSING, AND TREATING CANCER  
The present invention provides compositions and methods useful for diagnosing, treating, and preventing cancer, particularly ovarian cancer and uterine cancer, based on the discovery that the...
US20150023965 METHODS OF TREATING UROTHELIAL CARCINOMA  
Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.
US20140050730 METHODS FOR DIAGNOSING AND TREATING NEUROENDOCRINE CANCER  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2....
US20060002924 Conjugate of notch signalling pathway modulators and their use in medical treatment  
Conjugates comprising a plurality of modulators of the Notch signalling pathway chemically bound to a support structure are described. The conjugates are useful for modulation of the Notch...
US20130295108 METHOD FOR TREATING SYNOVIAL SARCOMA  
Methods of detecting synovial sarcoma using differentially expressed genes are disclosed. Also disclosed are methods of identifying agents for treating synovial sarcoma. Further, a method for...
US20150259435 HER2- AND VEGF-A-BINDING PROTEINS WITH ENHANCED STABILITY  
The invention provides HER2-binding proteins and VEGF-A-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided.
US20090155259 EXTENDING TIME TO DISEASE PROGRESSION OR SURVIVAL IN CANCER PATIENTS  
The present application describes extending time to disease progression or survival in a cancer patient, where the patient's cancer displays HER activation, by treating the patient with a HER...
US20110150894 METHODS OF MODULATING ANGIOGENESIS VIA TRPV4  
The present invention relates to methods of inhibiting capillary endothelial (CE) cell migration, the formation of CE networks and angiogenesis, and uses thereof for the purpose of treating...
US20140322130 SPECIFIC BINDING PROTEINS AND USES THEREOF  
The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express...
US20120308577 DNA VACCINES AND METHODS FOR THE PREVENTION OF TRANSPLANTATION REJECTION  
Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX...
US20150197574 USE OF TRANSFERRIN RECEPTOR ANTAGONIST FOR THE TREATMENT OF THALASSEMIA  
The present disclosure relates to antagonists of transferrin receptor and compositions and methods of use of said antagonists for treating pathological disorders such as thalassemia disorders
US20140370004 METHOD OF BOOSTING THE IMMUNE RESPONSE IN NEONATES  
In an aspect, a method of augmenting an immune response in a subject in need thereof, comprising identifying the subject, and treating the subject to inhibit the immune suppressive effect of CD71+...
US20120003219 Compositions and Methods to Treat Bone Related Disorders  
The present invention relates to the use of modulators of the sclerostin:sclerostin-binding-partner interaction for the treatment, amelioration, and diagnosis of sclerostin-related disorders,...
US20140255388 TOLL LIKE RECEPTOR 3 ANTAGONISTS, METHODS AND USES  
Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments, and methods of making and using the foregoing are disclosed.
US20130280263 Toll-Like Receptor 3 Antagonists  
Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
US20140120082 MODULATION OF NKG2D  
The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for...
US20150079104 Methods For Inhibiting The Binding Of Endosialin To Ligands  
The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression,...
US20110280885 CANCER IMMUNOTHERAPY  
A method for stimulating a immune response against IL-13Rα2 in a subject having or at risk for developing a disease having cells expressing IL-13Rα2 includes the steps of formulating the...
US20100297121 Methods for Treating Pressure Induced Optic Neuropathy, Preventing Neuronal Degeneration and Promoting Neuronal Cell Survival Via Administration of LINGO-1 Antagonists and TrkB Agonists  
This invention relates to methods for promoting neuronal survival and regeneration using LINGO-1 antagonists and TrkB agonists. Additionally, the invention relates to methods for treating pressure...
US20110044991 METHODS AND COMPOSITIONS FOR TREATING LYMPHOMA AND MYELOMA  
This invention relates to the use of antagonists of the hedgehog signaling pathway to induce apoptosis of lymphoma and myeloma cells and to treat subjects suffering from various forms of lymphoma...
US20130343996 GRAPHITE-COATED MAGNETIC NANOPARTICLES  
The present invention relates to graphite-coated magnetic nanoparticles, methods for the synthesis of graphite-coated magnetic nanoparticles, and methods of using graphite-coated magnetic...
US20110214194 COMPOSITIONS AND METHODS FOR MODULATING CELLS VIA CD14 AND TOLL-LIKE RECEPTOR 4 SIGNALING PATHWAY  
Compositions and methods are provided for screening and identifying compounds which modulate signaling of toll-like receptor 4 (TLR4) pathway via CD 14 and a ligand. Methods are provided for...
US20130011407 PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF OSTEOARTHRITIS, AND METHOD OF PRODUCTION THEREFOR  
Pharmaceutical compositions for treating or preventing diseases classified as any of grade 1 to 3 according to the ICRS classification of osteoarthritis, classified as any of grade 1 to 3...
US20100061994 MEDICAL USES OF 39-DESMETHOXYRAPAMYCIN AND ANALOGUES THEREOF  
The present invention relates to medical uses of 39-desmethoxyrapamycin analogues.