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US20150132312 SYSTEMS AND METHODS FOR EXTRACORPOREAL BLOOD MODIFICATION  
The present invention generally relates to systems and methods for targeted removal of a substance or biomolecule such as a protein from a biological fluid, such as blood. In some cases, the blood...
US20110020358 Methods and Compositions for Detecting Amyotrophic Lateral Sclerosis  
The invention provides binding proteins that bind to misfolded or monomeric SOD1, and not to native homodimeric SOD1. The invention also includes methods of diagnosing, detecting or monitoring...
US20150247847 DIAGNOSTIC METHOD FOR DETECTING AN AUTOIMMUNE DISEASE AND RELATED SUBJECT-MATTER  
The present invention relates to a polypeptide or protein for use in a method of diagnosis or treatment of an autoimmune disease in a subject, characterized in that said polypeptide or protein...
US20110091471 TREATMENT METHOD FOR EPITHELIAL CANCEROUS ORGANISM  
It is an object of the present invention to provide a novel method for decreasing the number of clinical cases for which trastuzumab administration is ineffective. The present invention provides a...
US20110038872 METHODS OF DIAGNOSING AND TREATING AUTISM  
The present invention provides diagnostic methods for determining the risk of developing an autism spectrum disorder (ASD) in a fetus or child by detecting in a biological sample from the mother...
US20100098698 TARGETED APHERESIS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS  
This invention uses “targeted apheresis” to treat rheumatoid arthritis patients. “Targeted Apheresis” is a process whereby the RF and immune complexes responsible for causing the disease symptoms...
US20060159680 Targeted apherisis for the treatment of rheumatoid arthritis  
This invention uses “targeted apheresis” to treat rheumatoid arthritis patients. “Targeted Apheresis” is a process whereby the RF and immune complexes responsible for causing the disease symptoms...
US20150219667 PRE-TRANSPLANT IgG REACTIVITY TO APOPTOTIC CELLS CORRELATES WITH LATE KIDNEY ALLOGRAFT LOSS  
It has been discovered that significantly elevated levels of anti-apoptotic cell IgG is an important contributor to and predictor of late graft rejection. Kaplan-Meier survival analysis revealed...
US20050238641 Endotoxin-binding ligands and their use  
An affinity ligand-matrix conjugate of the structure Z-Spacer-[NX-A]m-NY-A-NK2 is useful for the isolation, separation, purification, characterization, identification or quantification of...
US20080063645 Endotoxin-adsorbent for the prevention and treatment of autoimmune diseases  
It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model...
US20050249724 Extracorporeal stablised expanded bed adsorption method for the treatment of sepsis  
The present invention provides an extracorporeal adsorption method for removing harmful substances from blood in a way that is practicable in everyday clinical practice and applicable for the...
US20050203281 Production of recombinant fragments of muscle acetylcholine receptor and their use for ex vivo immunoadsorption of anti-ch receptor antibodies from myasthenic patients  
A procedure which involves the production of extracellular domains (or larger parts including these domains) of human muscle acetylcholine receptor (AChR) expressed in heterologous or homologous...
US20150079098 Method of treating cancer  
A method is described to treat cancer by extracorporeally treating a bodily fluid of a patient. A patient's body fluid is treated extracorporeally using a moiety that targets an antigen in the...
US20110071073 Detection of mutations in a gene associated with resistance to viral infection, OAS1  
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided...
US20110002921 COMBINATION CANCER IMMUNOTHERAPY WITH CO-STIMULATORY MOLECULES  
Provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer by administering an effective...
US20110002920 COMBINATION CANCER IMMUNOTHERAPY WITH CO-STIMULATORY MOLECULES  
Provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer by administering an effective...
US20060030027 Capture and removal of biomolecules from body fluids using partial molecular imprints  
The invention provides methods and devices for the capture and removal of target biomolecules from a patient's body fluid, particularly blood or a blood component, using a partial imprint...
US20050103712 Methods and devices for treating severe peripheral bacterial infections  
The present invention relates to novel methods and devices for treating severe bacterial infections, such as septicemia, using an extracorporeal adsorption container. The device has a solid...
US20140161810 EXTRACORPOREAL REMOVAL OF MICROVESICULAR PARTICLES  
The invention described herein teaches methods of removing microvesicular particles, which include but are not limited to exosomes, from the systemic circulation of a subject in need thereof with...
US20110129479 IMMUNOGEN SELECTION DIRECTED IN IMMUNOGLOBULIN PACKAGES IN PLASMA AND COLOSTRUM AND METHOD OF MAKING AND USING SAME  
A method for the selection and production of group specific immunoglobulins to bind to specific microbes or their toxins is provided. The immunoglobulins are produced in animals and collected...
US20120294865 Integrin Alpha-2 Binding Agents and Use Thereof to Inhibit Cancer Cell Proliferation  
The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject,...
US20050214265 Method for improving bone marrow engraftment  
The present invention demonstrates that a delay in marrow infusion is associated with a decrease in the amount of conditioning required and improved engraftment. Surprisingly, it has been...
US20100203147 Viruses for the Treatment of Cellular Proliferative Disorders  
Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately...
US20090074755 Use of panton-valentine leukocidin for treating and preventing staphylococcus infections  
The present invention relates to compositions and methods for treating Staphylococcus aureus (S. aureus) infections. In particular, the present invention provides vaccines comprising a...
US20110171226 Novel Subtype of Closteridium Botulinum Neurotoxin Type A and Uses Thereof  
A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also disclosed.
US20050158306 Treatment for neuro-degenerative disease by a blood cleansing system using monoclonal antibodies  
Neuro-degenerative diseases such as Alzheimer's Disease with circulating molecules that pass through the Blood Brain Barrier which can generate a monoclonal antibodies specific to the offending...
US20080286278 Process for in vivo treatment of specific biological targets in bodily fluids  
A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive...
US20150071935 Treatment for the rapid amelioration of clinical depression  
The present invention relates to an article and method of extracorporeal treating a patient's body fluid, for example, CSF (cerebrospinal fluid), lymph, or blood. The treatment includes a...
US20070092509 Method for ex-vivo separation of apoptotic chromatin fragments from blood or plasma for prevention and treatment of diverse human diseases  
A method of prevention/treatment of pathological consequences of DNA damage triggered by incorporation of circulating apoptotic chromatin fragments into healthy cells of individuals/patients in...
US20060241040 Methods of treating disorders associated with toll-like receptor 4 (TLR4) signalling  
Described herein are methods and compositions for treating, preventing, and diagnosing disorders associated with TLR4 signalling, e.g., gram negative bacterial infection and sterile inflammations...
US20070160599 THIMEROSAL REMOVAL DEVICE  
A device for the removal of heavy metals and heavy metal complexes, such as thimerosal, from medications is provided wherein the device comprises a dosing device or a solid support having at least...
US20050169889 Immunogenic agent therapy using plasmapheresis or exchange transfusion  
Lowering the level of antibody or complement in the blood of a subject by plasmapheresis or exchange transfusion prior to administering an immunogenic therapeutic agent containing a foreign...
US20120093825 METHOD FOR PRODUCING ANTIBODY USING "NAKED" EXPRESSION VECTOR EXPRESSING TYPE II TRANSMEMBRANE FUSION PROTEIN  
Methods are disclosed for generating antibodies and an expression vector used to express protein(s) which provoke the antibody response. The expression vector may be useful in generating an...
US20050255099 Antigenic fusion protein carrying Galalpha 1,3Gal epitopes  
The present invention relates to an antigenic fusionprotein, which carries multiple Galα1,3Gal epitopes. The fusion protein according to the invention may also be comprised of a heavily...
US20140294850 EARLY CHILDHOOD MEMBRANOUS NEPHROPATHY DUE TO CATIONIC BOVINE SERUM ALBUMIN  
The invention concerns a biomarker for diagnosing or prognosing childhood Membranous Nephropathy (MN), said biomarker is (i) cationic Bovine Serum Albumin (BSA), and/or (ii) an antibody that binds...
US20060034837 Method and agents for the prevention, inhibition and therapy of cancers  
Disclosed are uses of Gangliosides GM1 and/or asialo-GM1 substances simulating the carbohydrate portion of said gangliosides with regard to bonding to anti-GM1 antibodies and/or anti-ADM1...
US20100310646 SELECTIVE EXOSITE INHIBITION OF PAPP-A ACTIVITY AGAINST IGFBP-4  
The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4,...
US20050271653 Methods and devices for targeting a site in a mammal and for removing species from a mammal  
Methods and devices for improved targeting to a site in an organism, particularly to a tumor target site and for extracorporeal affinity adsorption, particularly in the treatment of cancer,...
US20060024301 Prostate-specific polypeptides and fusion polypeptides thereof  
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions...
US20110086036 COMPOSITION COMPRISING VLP AND AMYLOID BETA PEPTIDE  
The present invention relates to novel uses of a construct consisting of virus-like particle (VLP) structure chemically coupled to a fragment of the A□-1-42 peptide and its pharmaceutically...
US20050220785 Methods and formulations for reducing circulating antibodies  
The invention provides methods for reducing circulating levels of antibodies, particularly disease-associated antibodies. The methods entail administering effective amounts of epitope-presenting...
US20080069795 Amelioration of Drug-Induced Toxicity  
Kidney toxicity which is induced by cisplatin and other therapeutic and diagnostic agents, limits the effectiveness of the therapy or diagnosis. Modulation or depletion of T cells ameliorates the...
US20100098688 METHOD FOR DIAGNOSIS OF A DISEASE INVOLVING AN ANTI-AT1-RECEPTOR ANTIBODY  
The present invention relates to a method for diagnosis of a disease selected from the group of diabetes, vasculitis, collagenosis, an inflammatory rheumatic disease and arteriosclerosis wherein,...
US20110044989 Zona Pellucida Binding Peptides, Expression Vectors, Compositions, and Methods for Species Specific Immunocontraception of Animals  
Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions...
US20070141050 Methods of depleting antibodies directed towards major histocompatibility complex  
The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants,...
US20130224287 Liposome-Based Construct Comprising a Peptide Modified Through Hydrophobic Moieties  
The present invention relates to method for preparing liposome-based constructs comprising a peptide, particularly an antigenic peptide, of interest modified through hydrophobic moieties...
US20070081989 Treatment of B cell diseases using anti-germline antibody binding agents  
Methods for reducing the number of pathologic antibody producing B cells in a patient suffering from an autoimmune disease by administration of an anti-germline antibody are described. Methods for...
US20090246203 METHOD FOR IMMUNOADSORPTION BY MEANS OF AUTOANITGENS  
The invention relates to a novel method for immunoadsorption therapy of human autoimmune diseases by means of immobilized or fixed autoantigens.
US20060210558 Hematopoietic cell selectin ligand polypeptides and methods of use thereof  
The invention feature methods and compositions for treating inflammatory disorders, hematopoietic disorders and non-hematopoietic disorders (e.g., non-hematopoietic cancers) and for isolating...
US20110104226 PEPTIDES HAVING BINDING AFFINITY TO AN ANTIBODY WHICH RECOGNIZES AN EPITOPE ON AN A1 LOOP 2 OR BETA2 LOOP 1 OF AN ADRENORECEPTOR  
A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the...

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