Matches 151 - 200 out of 248 < 1 2 3 4 5 >


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US20070231319 Methods of treating inflammatory and autoimmune diseases with natalizumab  
Natalizumab is a safe and efficacious treatment for inflammatory and autoimmune diseases, such as multiple sclerosis, Crohn's Disease, and rheumatoid arthritis. Chain swapping between natalizumab...
US20110064725 HIGH AFFINITY, ANTI-HUMAN IGE ANTIBODIES  
The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and...
US20140178362 METHODS AND COMPOSITIONS FOR TREATING DISEASES TARGETING MABA  
Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of Maba in disease cells compared to healthy cells. Also provided are...
US20140212408 Anti-CEA Antibodies  
The present invention provides antigen binding molecules (ABMs) which bind membrane-bound CEA, including ABMs with improved therapeutic properties, and methods of using the same.
US20120082661 ANTI-BCMA ANTIBODIES  
This invention provides antibodies that recognize the B Cell Maturation Antigen (BCMA) and that bind naïve B cells, plasma cells, and/or memory B cells. The invention further provides methods for...
US20140242068 JAML SPECIFIC BINDING AGENTS, ANTIBODIES, AND USES RELATED THERETO  
Disclosed are specific binding agents such as antibodies and chimera that bind to JAM-like protein. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as...
US20100226914 METHOD FOR PREPARATION OF SINGLE CHAIN ANTIBODIES  
This invention provides a method for identifying cells expressing a target single chain antibody (scFv) directed against a target antigen from a collection of cells that includes cells that do not...
US20070041966 Polypeptides including modified constant regions  
Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an FcγR, which processes comprise modifying the polypeptides by substitution of...
US20050220785 Methods and formulations for reducing circulating antibodies  
The invention provides methods for reducing circulating levels of antibodies, particularly disease-associated antibodies. The methods entail administering effective amounts of epitope-presenting...
US20110076265 MONOCLONAL ANTIBODIES HAVING HOMOSUBTYPE CROSS-NEUTRALIZATION PROPERTIES AGAINST INFLUENZA A VIRUSES SUBTYPE H1  
A monoclonal antibody directed against the influenza A virus is described, which is capable of binding human and animal isolates of influenza A viruses expressing the H1-subtype hemagglutinin. A...
US20130243749 Humanized Monoclonal Antibodies and Methods of Use  
Disclosed is a humanized monoclonal antibody that binds to the human immunoglobulin heavy chain variable region germline gene VHI-69. The antibody is derived from Mab G6 and recognizes the same...
US20050031609 Compositions for use in treating ige-associated disorders  
The present invention provides methods of treating IgE-associated disorders and products for use therein. The methods comprise administering to a subject an amount of a first composition...
US20100330075 MONOCLONAL HUMAN TUMOR-SPECIFIC ANTIBODY  
Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions...
US20140134155 Antibodies against prostate-specific stem cell antigen and use thereof  
The invention relates to recombinant antibodies which bind to prostate-specific stem cell antigen (PSCA). The antibody of the invention comprises complementarity-determining regions (CDR) having...
US20100247520 MUTATED NETRIN 4, FRAGMENTS THEREOF AND USES THEREOF AS DRUGS  
The present invention relates to a protein comprising or consisting of one of the following sequences: the sequence SEQ ID NO: 2 or SEQ ID NO: 4, or a fragment of said sequence represented by one...
US20090220416 IMMUNOGLOBULIN ASSOCIATED CELL-SURFACE DETERMINANTS IN THE TREATMENT OF B-CELL DISORDERS  
The present invention provides methods, compositions and vaccines for specifically targeting immunoglobulin associated cell-surface determinants that are not shed into the blood of a host. In some...
US20060233787 Human cd3-specific antibody with immunosuppressive properties  
Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a...
US20070086994 Anti-nik antibodies and uses thereof  
An antibody or antibody preparation being capable of specifically binding the amino acid sequence of NF-&kgr B-inducing kinase (NIK) MAP3K14, or a specific portion thereof, and of thereby...
US20070065425 ANTI-IDIOTYPIC ANTIBODY NEUTRALIZING THE INHIBITOR ACTIVITY OF A FACTOR VIII INHIBITOR ANTIBODY  
The present invention is related to a monoclonal anti-idiotypic antibody directed against a Factor VIII inhibitor antibody binding to the domain A2 of Factor VIII, and to a cell line producing...
US20110243924 NOVEL METHODS  
The invention provides methods of inhalation treatment of a respiratory disease or condition in a patient in need to such treatment without producing in said patient systemic antimuscarinic...
US20100310551 IMMUNOGENIC, MONOCLONAL ANTIBODY  
The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.
US20100247521 Therapeutic and Diagnostic Methods Using TIM-3  
The application relates to methods of treating chronic viral infection by modulating Tim-3 activity. In addition, the present application relates to methods of diagnosing or monitoring immune...
US20100215647 Immunological Compositions as Cancer Biomarkers and/or Therapeutics  
The present invention concerns antibodies that react immunologically with anti-tumor antigen antibodies and compositions and methods related thereto. In particular, the antibodies that react...
US20100260748 ANTI-FcRH5 ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE  
The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
US20100098688 METHOD FOR DIAGNOSIS OF A DISEASE INVOLVING AN ANTI-AT1-RECEPTOR ANTIBODY  
The present invention relates to a method for diagnosis of a disease selected from the group of diabetes, vasculitis, collagenosis, an inflammatory rheumatic disease and arteriosclerosis wherein,...
US20050152893 Methods and materials for the inhibition of transplant rejection  
The present invention provides compositions and methods of inhibiting transplant rejection in a mammal, comprising administering one or more transplant rejection inhibiting compounds to the...
US20070269426 Use of Soluble Gammadelta Cell Receptors for Regulating T Cell Function  
Disclosed is a method of using soluble γδ T cell receptors to regulate a γδ T cell-mediated immune response in a mammal.
US20100247522 LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS  
Aspects of the present invention concern compositions that induce and/or improve an immune response to hepatitis C virus (HCV). Methods of making and using compositions that include epitopes of...
US20140271618 ANTIBODIES TO CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE (CEACAM)  
The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, recognizing a specific epitope of the protein CEACAM1 and optionally...
US20090130094 Cytotoxic Antibodies Directed Against Antibodies Inhibiting Factor VIII  
The invention relates to an anti-idiotypical antibody targeting an antibody inhibiting the human factor VIII, said inhibiting antibody targeting the C2 region of the human factor VIII, the...
US20110274684 CYTOTOXIC ANTIBODIES DIRECTED AGAINST ANTIBODIES INHIBITING FACTOR VIII  
The invention relates to an anti-idiotypical antibody targeting an antibody inhibiting the human fact VIII, said inhibiting antibody targeting the C2 region of the human factor VIII, the variable...
US20150056182 DRUG CONTAINING CARRIER INTO CELL FOR FORMING IMMUNE COMPLEX  
The present inventors discovered that by forming a large immune complex comprising antigens containing two or more antigenic binding units (epitopes) and two or more antigen-binding molecules (for...
US20100316630 ANTI-IDIOTYPE ANTIBODIES OF THE HUMAN MONOCLONAL ANTIBODY SC-1, AND THEIR PRODUCTION AND USE  
The invention features anti-idiotype antibodies of the human monoclonal antibody SC-1, as well as methods for producing and using the anti-idiotype antibodies.
US20100135948 Anti-Autoimmune Antibodies for Treatment of Pemphigus  
This invention relates to compositions and methods for the use of anti-autoimmune reagents that specifically bind to anti-desmoglein antibodies, which are responsible for both pemphigus vulgaris...
US20070274984 METHODS FOR TREATING AUTOIMMUNE DISEASES USING A TACI-IG FUSION MOLECULE  
In various embodiments, the present invention provides methods and compositions for treatment of autoimmune diseases, including rheumatoid arthritis, for example comprising administering to a...
US20060239999 Preventive and/or therapeutic drugs for asthma  
The present invention provides an agent for prevention and/or treatment of asthma comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active...
US20050147603 Autoantibodies utilized as carrier agents for pharmaceutical compounds used in tumor imaging and cancer treatment  
This invention describes a method whereby human autoimmune antibodies are used as carrier compounds to deliver imaging agents and pharmaceutical drugs to the tumor in the human patient. These...
US20150191547 HUMAN ANTI-KIR ANTIBODIES  
Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a...
US20070071717 Treatment of B cells with IL-21 and B cell activators induces Granzyme B production  
The present invention involves the combined use of IL-21 and TLR agonists such as CpG oligonucleotides in the treatment of B cell cancers and B cell-related immune pathologies such as autoimmune...
US20100291032 COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION  
Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or...
US20100183588 Mutated Netrin-4, Fragments Thereof And Their Use As Medicines  
Described is use of a netrin selected among netrin-4, mutated netrin-4, netrin-1, netrin G1 or netrin-3, or one of their fragments or a nucleotide sequence encoding one of the netrins or one of...
US20070178083 Medicinal compositions containing Fc receptor gamma-chain activator  
The present invention provides pharmaceutical compositions composing, as an active ingredient, a substance capable of activating the γ chain of Fc receptors (FcRγ) (provided that the substance is...
US20110236373 Method of detecting antibodies and antibody-hiv virion complexes  
The present invention relates, in general, to HIV and, in particular to a method of detecting anti-HIV antibodies and antibody-HIV virion complexes.
US20080274102 Antibodies to Nik, Their Preparation and Use  
An antibody or antibody fragment preparation being capable of specifically binding the amino acid sequence 60-76, 86-98, 135-149, 215-227, 363-377, 385-397, 405-419, 427-440, 509-522, 605-619,...
US20130078234 ANTI B7-H3 ANTIBODY  
An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods...
US20070081989 Treatment of B cell diseases using anti-germline antibody binding agents  
Methods for reducing the number of pathologic antibody producing B cells in a patient suffering from an autoimmune disease by administration of an anti-germline antibody are described. Methods for...
US20070003543 Low dose histone peptide treatment for autoimmune disorders  
The present invention provides low dose compositions comprising peptides and methods of using the same to treat autoimmune disorders, such as lupus. In particular, the present invention provides...
US20060165677 DELETION FORMS OF IgE-DEPENDENT HISTAMINE RELEASING FACTOR HAVING HISTAMINE RELEASING ACTIVITY, HRF-BINDING PEPTIDES AND THE USES THEREOF  
The present invention relates to IgE-dependent histamine releasing factor (HRF) and HRF-binding peptides, more precisely, deletion forms of HRF which are able to be formed as dimers containing...
US20130302314 ANTI-C EPSILON MX ANTIBODIES CAPABLE OF BINDING TO HUMAN MIGE ON B LYMPHOCYTES  
The invention pertains to the generation and utility of antibodies that can bind effectively to CεmX domain on membrane-bound IgE (mIgE) expressed on the surface of human B lymphocytes. The CεmX...
US20120207746 Anti-C epsilon mX antibodies capable of binding to human mIgE on B Lymphocytes  
The invention pertains to the generation and utility of antibodies that can bind effectively to CεmX domain on membrane-bound IgE (mIgE) expressed on the surface of human B lymphocytes. The CεmX...

Matches 151 - 200 out of 248 < 1 2 3 4 5 >