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US20130034539 |
SR-BI AS A PREDICTOR OF HUMAN FEMALE INFERTILITY AND RESPONSIVENESS TO TREATMENT
Methods of diagnosis and treatment of diseases and disorders related to de novo synthesis of cholesterol, based on allelic variants of the scavenger receptor class B type I receptor, and kits for...
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US20120121580 |
METHODS FOR PRODUCING HIGH CONCENTRATION LYOPHILIZED PHARMACEUTICAL FORMULATIONS
The present invention relates to methods of producing lyophilized pharmaceutical compositions comprising a high concentration of therapeutic protein or antibody prior to lyophilization, wherein the...
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US20120183495 |
AVIAN COLONY STIMULATING FACTOR 1 RECEPTOR BINDING PROTEINS
The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit immunomodulatory properties.
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US20120189626 |
TREATMENT OF COMPLEMENT-ASSOCIATED DISORDERS
The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.
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US20110104147 |
Identification of Tumor-Associated Markers for Diagnosis and Therapy
The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which...
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US20110212079 |
ADAPTIVE BIOCHEMICAL SIGNATURES
The present invention is related to methods of generating adaptive biochemical signatures in live cells and the use of said signatures to identify diagnostic and therapeutic modalities for human...
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US20120064036 |
Methods of Administration of Thrombopoietin Agonist Compounds
The embodiments provide methods of administering a high dose or a loading dose of a TPO modulator to a subject. The embodiments further provide methods of treating thrombocytopenia and/or...
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US20130121990 |
PHARMACEUTICAL FORMULATIONS
A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.
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US20100297106 |
Pharmaceutical Formulations
A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.
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US20120148566 |
PRODUCT AND METHOD FOR TREATMENT OF CONDITIONS ASSOCIATED WITH RECEPTOR-DESENSITIZATION
Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell...
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US20100196351 |
SECRETED PATE-LIKE PROTEINS
Novel PATE-like polynucleotides and polypeptides, are provided. Also described are splice-variants resulting in smaller polypeptides including five cysteine residues and capable of forming...
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US20100316650 |
SOLUBLE MIC POLYPEPTIDES AS MARKERS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT OF CANCER AND AUTOIMMUNE DISEASES OR CONDITIONS
The present invention provides prognostic and diagnostic methods for cancer, as well as methods for monitoring or staging cancer. Methods involve assaying for tumor-derived soluble MIC...
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US20110014185 |
METHODS INVOLVING GRAF POLYPEPTIDES
The invention relates to a method of identifying a modulator of clathrin-independent endocytosis, said method comprising (i) providing a GRAF protein, said GRAF protein comprising a GAP domain;(ii)...
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US20120134983 |
Method for Identifying Interventions that Control the Translational Activity of Ribosomal Proteins in Different MRNA Expression
The present invention relates to systems and methods for screening compounds and/or mutant ribosomal proteins in a eukaryotic cell that increase or decrease the translation of a target gene and...
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US20110274739 |
METHODS FOR GOVERNING TISSUE GROWTH
Resorbable polymer barrier membranes and methods of their applications are disclosed. In a broad embodiment, methods of governing tissue growth, or preventing tissue growth into a certain spatial...
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US20100316593 |
Pharmaceutical Formulations
A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active...
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US20100310585 |
THE USE OF MONOMYCOLYL GLYCEROL (MMG) AS AN ADJUVANT
Here we identify MMG and its alpha- and ketomycolic acid derivatives as highly bioactive lipids derived from M. bovis BCG (Copenhagen) capable of stimulating and activating human DC's at...
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US20110206617 |
MODIFIED POLYSACCHARIDES FOR DRUG AND CONTRAST AGENT DELIVERY
According to one embodiment, the disclosure provides a delivery formulation including a chitosan in which the primary amines are partially modified with 4-imidazole acetic acid monohydrochloride...
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US20110091444 |
Methods and compositions for treatment and prevention of major depressive disorder
The present invention relates to methods of diagnosing, prognosing or treating diseases or disorders in which elevated levels of Abeta protein, including abeta1-42 are prevalent. In particular, the...
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US20130108617 |
PLASMA-DERIVED IMMUNOGLOBULIN FOR USE IN THE TREATMENT AND PREVENTION OF IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME (IRIS)
The present invention relates to plasma-derived immunoglobulin for use in the treatment of immune reconstitution inflammatory syndrome (IRIS). Moreover, the present invention relates to a kit of...
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US20110311512 |
Genetic Variants Underlying Human Cognition and Methods of Use Thereof as Diagnostic and Therapeutic Targets
Compositions and methods for the detection and treatment of neurological disorders, including ASD, are provided.
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US20120321692 |
Methods and Dressings for Sealing Internal Injuries
Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal...
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US20110059089 |
Protein Markers for Cardiovascular Events
The present invention relates to a method for predicting the risk of a subject developing a cardiovascular event comprising detecting at least one biomarker in (a sample of) the cardiovascular...
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US20110123454 |
Method for modulating appetite
The present invention provides a method of modulating appetite and/or body weight in a subject, said method comprising administering to said subject an effective amount of a MIC-1-modulating agent,...
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US20110123521 |
METHODS FOR MODULATING EXPRESSION OF RBP4
Methods are provided for modulating RBP4 by administering a RBP4-specific modulator. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or...
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US20130095093 |
METHODS AND COMPOSITIONS FOR TREATMENT OF IMMUNE DYSFUNCTION DISORDERS
Methods and compositions are disclosed for modulating the immune system of animals. Applicant has identified that oral administration of immunoglubulin or plasma fractions purified from animal...
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US20100316628 |
AGENTS AND METHODS FOR TREATING RESPIRATORY DISORDERS
The present invention relates to a novel method of preventing and/or treating respiratory disorders and respiratory-related complications in a subject by inhibiting the release of nitric oxide from...
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US20080075696 |
Treatment Of Hepatitis C In The Asian Population With Interferon-Beta
The invention relates to the use of IFN-beta in the manufacture of a medicament for the treatment of an HCV infection in a treatment-naïve patient belonging to the Asian population.
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US20110027278 |
REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A ...
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US20110086022 |
Methods for diagnosing and treating neuroendocrine cancer
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods...
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US20120020961 |
METHODS AND COMPOSITIONS FOR LIVER CANCER THERAPY
The present disclosure provides methods of treating liver cancer and preventing liver cancer recurrence with anti-progastrin antibodies, methods of monitoring treatment efficacy of anti-progastrin...
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US20120164136 |
Compositions and Methods for Treatment of Cancer by Disrupting the LH/LHR Signaling Pathway
The present invention discloses compositions and methods for treating diseases such as cancer by targeting luteinizing hormone (LH) or its receptor (LHR) involved in androgen synthesis or...
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US20130095094 |
ASSAY
The invention provides assays and apparatuses for assessing the ability of certain orally-ingestible samples, such as saliva or foodstuffs to cause inflammation, and thus the health risk such...
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US20110243923 |
ORGANIC COMPOUNDS
The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7, 25-dihydroxycholesterol) (“7,25DHC”) and...
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US20120148495 |
METHODS FOR TREATING NICOTINIC ACETYLCHOLINE RECEPTOR ASSOCIATED DISEASES
The present invention provides methods and compositions for treating subjects suffering from a disorder associated with a nicotinic acetylcholine receptor (nAChR), methods for treating a subject...
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US20120141484 |
METHODS OF PREVENTING INFLAMMATION AND TREATING PAIN USING ANTI-NGF COMPOSITIONS
Monovalent agents, including Fab fragments and monovalent monoclonal antibodies analogous to MetMab, having binding specificity to human Nerve Growth Factor (“NGF”), and methods treating pain in ...
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US20120315264 |
ZWITTERIONIC IMMUNOMODULATORS FOR THE TEATMENT OF ASTHMA AND ALLERGY
Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic...
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US20120321719 |
Sustained Delivery of Therapeutic Agents to an Eye Compartment
Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a...
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US20120150087 |
SOLID DRESSING FOR TREATING WOUNDED TISSUE
Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and thrombin,...
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US20120171198 |
USE OF IGG1 IMMUNOGLOBULINS AND/OR LIGANDS OF THE CD32 RECEPTOR FOR TREATING INFLAMMATORY DISEASES AND MANIFESTATIONS VIA THE MUCOSAL ROUTE
The present invention concerns the use of immunoglobulins of IgG1 type, and more generally of ligands of the CD32 receptor, for the treatment of inflammatory diseases and manifestations, in...
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US20110217288 |
Involvement of Androgen/Androgen Receptor Pathway in Fabry Disease
Novel therapies for the treatment of Fabry disease by using androgen/androgen receptor (AR) pathway-related molecules as biomarkers and use of approaches targeting androgen/AR pathway are presented...
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US20110123535 |
Use of Nogo Receptor-1 (NGR1) for Promoting Oligodendrocyte Survival
The invention provides methods of treating diseases, disorders or injuries involving oligodendrocyte death, demyelination and dysmyelination, including spinal cord injury, by the administration of...
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US20120294866 |
PHARMACEUTICAL FORMULATION FOR PROTEINS
The present invention provides a liquid pharmaceutical formulation comprising a therapeutic protein, a surfactant and at least an antioxidant selected from the group of radical scavengers,...
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US20110165149 |
TARGETING ABCB5 FOR CANCER THERAPY
The invention related to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules...
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US20110129422 |
Viscous Terpolymers as Drug Delivery Platform
Disclosed are terpolymer compositions of lactide, glycolide, and caprolactone and methods of making such polymers with an initiator. Methods of using the terpolymers as a drug delivery platform are...
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US20110010780 |
KCNN3 AS DIAGNOSTIC AND THERAPEUTIC TARGET FOR NEURODEGENERATIVE DISEASES
The present invention discloses a dysregulation of the KCNN3 gene and the protein products thereof in Alzheimer's disease patients and individuals being at risk of developing Alzheimer's disease....
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US20110150877 |
EPHRIN-B RECEPTOR PROTEIN INVOLVED IN CARCINOMA
The present invention provides a polypeptide (CCMP-1) of use in the diagnosis, screening, treatment and prophylaxis of carcinoma. Also provided are compositions comprising the protein, vaccines and...
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US20110200585 |
CD127 BINDING PROTEINS
Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in...
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US20110020359 |
METHODS AND COMPOSITIONS FOR TREATING NEURONAL DAMAGE OR DEGENERATION
This invention provides methods and compositions for reducing chondroitin-sulfate-proteoglycan-mediated inhibition of neuronal growth. The methods and compositions provided herein are particularly...
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US20100330071 |
METHOD TO PRODUCE A HIGHLY CONCENTRATED IMMUNOGLOBULIN PREPARATION FOR SUBCUTANEOUS USE
The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20%...
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