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US20120052010 IMAGING TUMOR PERFUSION, OXIDATIVE METABOLISM USING DYNAMIC ACE PET IN PATIENTS WITH HEAD AND NECK CANCER DURING RADIOTHERAPY  
The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Non-invasive methods for assessing tumor perfusion and oxidative metabolism for in vivo...
US20120207678 Labeled Adenosine for Use in Positron Emission Tomography  
Radiolabeled adenosine or radiolabeled adenosine containing molecules for use in positron emission tomography for assessing alterations in adenylate metabolism in a patient are provided.
US20120121508 RADIOLABELED CGRP ANTAGONISTS  
The present invention is directed to radiolabeled CGRP receptor antagonists which are useful for the quantitative imaging of CGRP receptors in mammals.
US20120064004 ISOTOPOLOGUES OF THALIDOMIDE  
Provided herein are thalidomide, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are...
US20110293520 NEW DRUG FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES  
The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of...
US20130084245 PET MONITORING OF A-BETA-DIRECTED IMMUNOTHERAPY  
The present invention provides methods of monitoring Aβ-directed immunotherapy. The methods involve administering a PET ligand that binds to amyloid deposits and detecting the PET ligand in the...
US20130034495 ISOTOPOLOGUES OF 4-[9-(TETRAHYDRO-FURAN-3-YL)-8-(2,4,6-TRIFLUORO-PHENYLAMINO)-9H-PURIN-2-YLAMINO]-CYCLOHEXAN-1-OL  
Provided herein are isotopologues of Compound 1, which are enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and...
US20140079635 MOLECULAR PROBES FOR DETECTING LIPID COMPOSITION  
A method of detecting myelin in a subject includes administering to the subject a molecular probe that includes a fluorescent trans stilbene derivative and detecting the amount or distribution of...
US20130164217 METHOD OF DIAGNOSING, PREVENTING AND/OR TREATING DEMENTIA & RELATED DISORDERS  
Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild...
US20150157743 Dose Synthesis Card for Use with Automated Biomarker Production System  
Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron...
US20120276006 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING  
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds...
US20150079001 IMAGING AGENTS AND METHODS OF IMAGING NAALADASE OR PSMA  
The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of...
US20120276007 IMAGING AGENTS AND METHODS OF IMAGING NAALADASE OR PSMA  
The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of...
US20100310456 IMAGING OF MYELIN BASIC PROTEIN  
The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering...
US20120039803 PRETARGETING KIT, METHOD AND AGENTS USED THEREIN  
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal...
US20130034496 POSITRON EMISSION TOMOGRAPHY TRACER  
The present invention relates to positron emission tomography tracers and methods of using these tracers.
US20140086836 METHOD FOR DETECTION OF A NEUROLOGICAL DISEASE  
The present invention provides methods for predicting whether a subject will develop a disease capable of affecting cognitive function. More specifically, the present invention relates to the...
US20130084244 METHOD OF DIFFERENTIALLY DIAGNOSING DIFFERENT TYPES OF DEMENTIA  
The present invention relates to a method of differentially diagnosing different types of dementia. In particular, the method relates to the use of specific SPECT tracers for differentially...
US20130230459 RADIOLABELLED mGluR2 PET LIGANDS  
The present invention relates to novel, selective, radiolabelled mGluR2 ligands which are useful for imaging and quantifying the metabotropic glutamate receptor mGluR2 in tissues, using...
US20140004044 USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING  
The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including for the treatment of...
US20150157745 PROBE FOR A BIOLOGICAL SPECIMEN AND LABELLING METHOD AND SCREENING METHOD USING THE PROBE  
Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent...
US20110008254 RADIOPHARMACEUTICAL COMPOSITION  
The present invention relates to radiopharmaceuticals and in particular to a radiopharmaceutical composition comprising a compound of Formula (I): and polysorbate as an excipient. The...
US20130259805 DEVELOPMENT AND SCREENING OF CONTRAST AGENTS FOR IN VIVO IMAGING OF PARKINSON'S DISEASE  
The invention provides compounds and a method for imaging aggregated α-synuclein, e.g., Lewy bodies or Lewy neurites, in a tissue or organ.
US20120321561 CANCER DIAGNOSIS AND IMAGING  
The present invention provides a method for imaging a disease or condition in a mammal which includes the steps of; administering a therapeutically effective amount of a cell cycle inhibitor to...
US20110189090 MOLECULAR PROBES FOR IMAGING OF MYELIN  
A molecular probe for labeling myelin includes a fluorescent trans-stilbene derivative.
US20130302246 COMPOSITIONS AND METHODS FOR DELIVERING A SUBSTANCE TO A BIOLOGICAL TARGET  
The present application provides compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reaction for rapid and specific covalent delivery of a “payload” to...
US20120128588 ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME  
Disclosed are: labeled NSAIDs compounds which can be produced within a short time, can be used suitably for a PET method, and enable the imaging of cyclooxygenase-2; and a process for producing...
US20140369932 USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING  
The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including their use to diagnose...
US20120107238 COMPOUND CONTAINING A CARBON OR AN OXYGEN ISOTOPE, PREPARATION AND USE THEREOF, AND COMPOSITION COMPRISING THEREOF  
The present disclosure relates to a compound comprising at least one of a carbon or an oxygen isotope and a process for preparing the compound. The process comprises irradiating a compound...
US20130156699 RADIOLABELED COMPOUNDS AND USES THEREOF  
The present invention relates to Radiolabeled Compounds labeled with fluorine, bromine, iodine, carbon, or tritium isotopes and methods of use thereof for treating or preventing a psychiatric...
US20110293518 DIAGNOSIS OF WHIPLASH ASSOCIATED DISORDERS (WAD) BY USING PET WITH D-[METHYL-11C]-DEPRENYL (DDE)  
Positron Emission Tomography (PET) tracers such as D-[methyl-11C]-Deprenyl (DDE) and [11C]-GR205171 (GLD), methods for and methods of preparing biological mechanisms that identify treatment...
US20120183474 Methods and System for Detecting Soluble Amyloid-Beta  
The present invention provides methods of detecting soluble amyloid β using curcumin-derived near infrared (NIR) imaging probes. Upon interacting with soluble amyloid β, these probes undergo a...
US20100329979 Method and Composition to Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using a Breath Test  
The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath...
US20110091382 NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION  
Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective...
US20140301947 METHODS TO PREDICT BINDING AFFINITY OF TSPO IMAGING AGENTS TO TSPO  
A method for aiding in selecting or adjusting a dose of TSPO imaging or therapeutic agent for use with a subject, the method comprising the step of determining the subject's genotype for TSPO...
US20110208064 Curcumin Derivatives for Amyloid-Beta Plaque Imaging  
The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid β aggregates, these probes undergo a range of changes, qualifying them as “smart”...
US20120251448 Compounds for Use in the Detection of Neurodegenerative Diseases  
Provided are the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of pathological characteristics unique to synuclein diseases, such as Parkinson's...
US20110212025 TSPO-TARGETING COMPOUNDS AND USES THEREOF  
Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
US20130272959 AGENTS FOR CLEARING BIOMOLECULES FROM CIRCULATION  
Described is a method, and a combination of agents for used therein, by which an agent administered to a subject can be rapidly cleared from circulation. This is achieved by providing an...
US20130101508 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID  
Radiopharmaceutical compositions, and related methods, useful for medical imaging are provided. The radiopharmaceutical compositions include one or more radiopharmaceutical compounds, together...
US20120237445 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID  
Radiopharmaceutical compositions, and related methods, useful for medical imaging are provided. The radiopharmaceutical compositions include one or more radiopharmaceutical compounds, together...
US20110305635 MYELIN DETECTION USING BENZOFURAN DERIVATIVES  
The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope...
US20130156700 FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2  
A method for positron emission tomography (PET) imaging of LRRK2 in tissue of a subject, the method comprising: administering a compound of formula I, formula II or formula III, or a...
US20100196274 Methods for Diagnosing Diseases and Evaluating Treatments Therefor Using Pet  
The present invention relates to methods for determining whether a mammal has a disease, such as diabetes, using PET data analysis techniques. These methods include administering to a mammal a...
US20140134105 HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY  
The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable...
US20130315826 Beta-Amyloid Plaque Imaging Agents  
Various compounds, compositions, and methods for binding to β-amyloid plaque and norepinephrine transporters are presented. Especially preferred compounds include those with a PET-detectable label.
US20120189545 ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS  
Benzofuran compounds which contain at least one detectable label selected from the group consisting of 131I, 123I, 124I, 125I, 76Br, 75Br, 18F, 19F, 11C, 13C, 14C and 3H are provided as amyloid...
US20140112868 NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES  
The invention relates to a new class of compounds with high affinity and selectivity towards P-glycoprotein. The invention also relates to the utilization of such compounds in the in vivo...
US20070196273 Oral DTPA for radionuclide chelation  
A composition for oral radionuclide chelation therapy comprises a DTPA chelate selected from Zn-DTPA and Ca-DTPA and a permeation enhancer that preferentially increases jejunal uptake of the DTPA...
US20150202332 LABELED MOLECULAR IMAGING AGENTS AND METHODS OF USE  
Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting...
Matches 1 - 50 out of 171 1 2 3 4 >