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US20110123444 |
Use of radioactively labelled molecule specifically binding to ED-B fibronection in a method of treatment of Hodgkin lymphoma
The invention relates to the use of a radioactively labelled molecule specifically binding to ED-B fibronectin in a method of treatment for patients with Hodgkin lymphoma, in particular primary...
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US20110250131 |
Antigens Associated with Endometriosis, Psoriatic Arthritis and Psoriasis
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, and/or for use in delivery to the...
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US20110027173 |
EPHRIN TYPE-A RECEPTOR 10 PROTEIN
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer,...
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US20120114555 |
METHOD FOR TREATING IMMUNE DISORDERS
The present invention relates to the treatment of B-cell mediated immune disorders such as rheumatoid arthritis, systemic lupus erythromatomus, diabetes mellitus, and multiple sclerosis. In...
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US20110195019 |
NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 251P5G2 USEFUL IN TREATMENT AND DETECTION OF CANCER
A novel gene 251P5G2 and its encoded protein, and variants thereof, are described wherein 251P5G2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
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US20110171127 |
NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 162P1E6 USEFUL IN TREATMENT AND DETECTION OF CANCER
A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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US20100297006 |
NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 191P4D12(b) USEFUL IN TREATMENT AND DETECTION OF CANCER
A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in...
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US20100297005 |
NUCLEIC ACIDS AND CORRESPONDING PROTEIN ENTITLED 125P5C8 USEFUL IN TREATMENT AND DETECTION OF CANCER
A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in...
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US20110002845 |
METHODS OF TREATING, DIAGNOSING OR DETECTING FGF21-ASSOCIATED DISORDERS
The invention provides, inter alia, methods for treating cancer and vascular disease, compositions for treating cancer and vascular disease, and methods and compositions for diagnosing and/or...
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US20110091378 |
Methods and Compositions for Treating Fibrosis Related Disorders Using IL-17 Antagonists
The present invention relates methods and compositions for treating interleukin-17 (IL-17) related conditions, such as IL-17A or IL-17F, or muteins thereof in patients having fibrosis using IL-17...
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US20110305630 |
MISFOLDED PROTEINS IN CANCER TREATMENT AND DIAGNOSIS
Cancer cells are identified and inhibited using agents that bind to epitopes unique to misfolded forms of surface proteins presented by the cancer cells. In one embodiment, cancer cells are...
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US20120121505 |
THERAPEUTIC COMPOSITIONS AND METHODS
The present application provides novel binding proteins, including human binding proteins that specifically bind to the human ErbB2.
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US20110236307 |
IN VIVO IMAGING METHOD
The present invention provides an in vivo imaging method that facilitates the diagnosis of Parkinson's disease (PD) at an early stage. Early diagnosis is particularly advantageous as...
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US20120087860 |
METHODS FOR IN VIVO CANCER DETECTION, DIAGNOSIS AND THERAPY USING MULTIDOMAIN BIOTAGS
In another embodiment, a method for detecting and/or diagnosing a cancer in a subject is provided. The method may include administering an effective dose of a biotag to a subject, or alternatively,...
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US20110262349 |
Methods and Agents for the Diagnosis and Treatment of Hepatocellular Carcinoma
The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to polypeptide antagonists of PLVAP proteins,...
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US20110085973 |
Methods and Agents for the Diagnosis and Treatment of Hepatocellular Carcinoma
The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as...
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US20110014119 |
Methods for Manipulating Phagocytosis Mediated by CD47
Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
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US20110059011 |
DIAGNOSIS AND TREATMENT OF DISEASED AND DAMAGED TISSUE
The present invention relates to the diagnosis and treatment of leukemia and cardiovascular disease, as well as the detection of diseased and damaged tissue. More particularly, the present...
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US20110123443 |
PANCREATIC BETA-CELL MASS BIOMARKER
A biomarker for pancreatic beta-cell mass comprising measuring the levels of CFC1 in the serum of a subject is described. The biomarker provides a noninvasive means for measuring pancreatic beta...
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US20110085972 |
NANOTUBES FOR CANCER THERAPY AND DIAGNOSTICS
The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT),...
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US20110085971 |
NANOTUBES FOR CANCER THERAPY AND DIAGNOSTICS
The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT),...
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US20110027174 |
NANOTUBES FOR CANCER THERAPY AND DIAGNOSTICS
The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT),...
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US20110280800 |
IL-1 BINDING PROTEINS
Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL...
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US20110165071 |
Methods Of Treating Cancer
Disclosed are methods of treating subjects having cancers including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human...
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US20110008250 |
Treatment of Autoimmune Diseases
The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
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US20120082618 |
PROSTATE CANCER DIAGNOSIS AND TREATMENT
The present invention relates to novel antibodies and their use for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastasis thereof. The present invention also...
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US20110064654 |
PROSTATE CANCER DIAGNOSIS AND TREATMENT
The present invention relates to novel antibodies and their use for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastasis thereof. The present invention also...
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US20120034161 |
PRETARGETING KIT, METHOD AND AGENTS USED THEREIN
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal...
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US20110212024 |
MARKER FOR INFLAMMATORY CONDITIONS
Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
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US20100143246 |
Interleukin 17 Receptor-Like Protein
The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human...
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US20110217232 |
Method for Determination of the Responsiveness of an Individual to Misletoe Lectin
A method for the determination of the responsiveness of an individual to mistletoe lectin or to (an) mistletoe lectin single chain(s), wherein the expression of a membrane-bound receptor for...
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US20120003150 |
THERAPEUTIC RIBONUCLEASES
The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
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US20110212023 |
TADG-15: an extracellular serine protease overexpossed in carcinomas
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression...
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US20120045390 |
Composition and Methods for the Diagnosis and Treatment of Tumor
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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US20110300069 |
Methods of Using Labeled Ligands Having Human CD4 Specificity
The invention concerns the use of a labelled ligand having specificity for the human CD4 molecule to produce a diagnostic agent for analysing migration and/or distribution patterns of certain cell...
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US20110243842 |
MAMMALIAN RECEPTOR PROTEINS; RELATED REAGENTS AND METHODS
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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US20110081292 |
Methods Of Treating Viral Hepatitis
Disclosed are methods of treating viral hepatitis including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal...
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US20110076232 |
SPECIFIC BINDING PROTEINS AND USES THEREOF
The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR...
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US20120107233 |
Cytotoxicity Mediation of Cells Evidencing Surface Expression of CD44
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease...
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US20110189086 |
Diagnostic Method for Atherosclerosis
The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible...
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US20110052488 |
Methods For Treating, Diagnosing, and Monitoring Rheumatoid Arthritis
Methods of identifying, diagnosing, and prognosing rheumatoid arthritis are provided, as well as methods of treating rheumatoid arthritis. Also provided are methods for identifying effective...
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US20110003710 |
SELECTIN LIGANDS USEFUL IN THE DIAGNOSIS AND TREATMENT OF CANCER
The present invention provides methods and compositions useful in the diagnosis and treatment of cancer. More specifically, the present invention provides compositions and methods of use comprising...
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US20110038791 |
METHODS FOR INHIBITING SIX1 AND EYA PROTEINS
In some aspects, the invention provides a method of inhibiting interaction of Six1 with Eya2 comprising contacting a cell expressing Six1 and Eya2 with an agent that inhibits binding of Six1 to...
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US20100221176 |
METHODS AND COMPOSITIONS FOR PROTEIN LABELLING
A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
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US20050129615 |
Non-invasive system for detecting skin cancer
The invention concerns methods and compositions for the diagnosis of cancer. The invention further concerns diagnostic patches which may be contacted topically with an externally accessible tissue...
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US20110262350 |
BREAST ENDOTHELIAL CELL EXPRESSION PATTERNS
To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from...
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US20110091377 |
BIOMARKERS FOR MELANOMA
The present invention relates to methods of determining melanoma status in a subject. The invention also relates to kits for determining melanoma status in a subject. The invention further relates...
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US20110223103 |
Multimodal Imaging of Atherosclerotic Plaque Targeted to LOX-1
The present invention provides multiple modalities for detecting LOX-1. More particularly, an imaging composition is provided that allows for the in vivo imaging of atherosclerotic plaque.
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US20080118432 |
Monitoring cancer stem cells
The present invention is directed to methods of monitoring cancer stem cells in patients undergoing cancer therapy to determine whether the cancer therapy is an effective cancer therapy. The...
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US20120121503 |
Inhibition Of CD69 For Treatment Of Inflammatory Conditions
A method of treating or reducing at least one inflammatory condition or the susceptibility to at least one inflammatory condition is provided involving administering at least one CD69 antagonist to...
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