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US20120010601 ORTHOPEDIC CEMENT AND USE OF SAME IN RADIATION THERAPY  
A method of treating diseased tissue in a patient, the diseased tissue being proximate a hardened previously implanted bone cement including relatively high atomic number elements in a patient....
US20110054237 Methods and Systems for Magnetic Focusing of Therapeutic, Diagnostic or Prophylactic Agents to Deep Targets  
Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the...
US20130230454 Therapeutic Angiogenesis for Treatment of the Spine and Other Tissues  
Methods for the diagnosis and treatment of ischemic spinal conditions, degenerative disc disease, back pain and/or other tissue pathologies. Patients with ischemic spine disease can be categorized...
US20140363374 COUPLED IDENTIFICATION AND TREATMENT OF CANCER  
Provided are methods to treat cancer, in which (1) a patient is first identified as having a cancer that is likely to be susceptible to gallium therapy, by the use of a gallium scan or other...
US20140314662 METHODS AND KITS FOR THE PROGNOSIS OF COLORECTAL CANCER  
The invention relates to methods for predicting the risk of relapse of cancer patients as well as methods for providing personalized medicine to said patients based on the expression levels of...
US20100168554 Evaluating Cardiac Function With Dynamic Imaging Techniques and Contrast Media  
Methods suitable for use in diagnostic imaging or to generate a central circulatory turnover (CCT) index for an evaluation of cardiac function of a patient are provided. The resultant CCT index...
US20120201747 System and Method for Diagnosis and Treatment  
This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy...
US20130259800 COMPOSITIONS AND METHODS FOR CANCER TREATMENT  
The invention described herein pertains to the use of oxazolidinone antibiotics, alone or in combination, in the treatment of cancer. In particular, the invention pertains to the treatment of...
US20150167103 GENE SIGNATURES FOR CANCER PROGNOSIS  
Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.
US20120123189 ONCOLOGY THERAPIES EMPLOYING RADIOACTIVE SEEDS  
An oncology therapy method comprises implanting a radioactive seed (10, 20, 30, 40, 50) in an oncology subject (S). In some embodiments the radioactive seed comprises a radioactive material (12,...
US20120014868 METHODS TO DIAGNOSE DEGENERATIVE DISC DISEASE  
Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck or back pain so as to improve the diagnosis of...
US20130121912 MICRORNA-198 AS A TUMOR SUPPRESSOR IN PANCREATIC CANCER  
A novel network of tumorigenic prognostic factors is identified that plays a critical role in advanced pancreatic cancer (PC) pathogenesis. This interactome is interconnected through a central...
US20120039798 METHODS OF MODIFYING P53 ACETYLATION AND TREATING CANCER USING AVRA  
The present invention relates to methods and compositions for the treatment of cancer. The methods and compositions involve the use of the Salmonella effector protein AvrA, as well as variants or...
US20120010599 INORGANICALLY SURFACE-MODIFIED POLYMERS AND METHODS FOR MAKING AND USING THEM  
In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned)...
US20150125384 MODULAR NANODEVICES FOR SMART ADAPTABLE VACCINES  
Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric...
US20110033376 Treatment of Melanoma  
There is described dexanabinol, or a derivative thereof, for the treatment of melanoma. There is also described a method of treating a patient suffering from melanoma.
US20130230455 USE OF GELSOLIN TO TREAT MULTIPLE SCLEROSIS AND TO DIAGNOSE NEUROLOGIC DISEASES  
The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
US20120107231 METALLOPROTEINASE BINDING PROTEINS  
Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
US20140356281 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20140271458 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20120282167 METHOD FOR PREDICTING THE SENSITIVITY OF A TUMOR TO AN EPIGENETIC TREATMENT  
The present invention provides a method for determining the RES phenotype in a tumor. The present invention further provides a method for predicting the sensitivity of a tumor to an epigenetic...
US20120030780 TARGETING OF SALL4 FOR THE TREATMENT AND DIAGNOSIS OF PROLIFERATIVE DISORDERS ASSOCIATED WITH MYELODYSPLASTIC SYNDROME (MDS)  
The present invention discloses nucleic acids, proteins, and antibodies for SALL4 (including isoforms SALL4A, SALL4B, and SALL4C), a zinc finger transcriptional factor. Further, methods are...
US20140271453 METHODS FOR THE EARLY DETECTION OF LUNG CANCER  
Provided are methods of diagnosing lung cancer, particularly at an early stage, such as stage I, by detecting the presence and/or amount of at least four biomarkers of lung cancer in a sample from...
US20140219913 Dual Specific Binding Proteins Having a Receptor Sequence  
Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20120063997 DELIVERY SYSTEM WITH SCAFFOLDS  
An injectable, agent delivery system comprising a composition comprising: (i) an injectable scaffold material comprising discrete particles, which are capable of interacting to form a scaffold;...
US20130129614 Microorganisms for imaging and/or treatment of tumors  
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in...
US20120244068 Microorganisms for imaging and/or treatment of tumors  
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in...
US20120321552 Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin  
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
US20110104050 Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin  
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
US20130129616 GEL COMPOSITION FOR FILLING A BREAST MILK DUCT PRIOR TO SURGICAL EXCISION OF THE DUCT OR OTHER BREAST TISSUE  
The invention is a gel composition for delivery to a breast milk duct prior to surgical excision of breast tissue including cancerous lesions. The invention also provides methods of mapping all or...
US20110044894 Immunoglobulin and/or Toll-Like Receptor Proteins Associated with Myelogenous Haematological Proliferative Disorders and Uses Thereof  
The disclosure relates to methods and compositions effective in the diagnosis, prognosis and treatment of human hematopoietic cancers. In particular, the disclosure provides tumor-associated genes...
US20130202525 MULTIFUNCTIONAL NANOPLATFORMS FOR FLUORESCENCE IMAGING AND PHOTODYNAMIC THERAPY DEVELOPED BY POST-LOADING PHOTOSENSITIZER AND FLUOROPHORE TO POLYACRYLAMIDE NANOPARTICLES  
A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.
US20130084241 DEVELOPMENT OF miRNA DIAGNOSTICS TOOLS IN BLADDER CANCER  
The present invention includes methods and compositions related to diagnosis of bladder cancer, including the presence of bladder cancer and/or the type or stage of bladder cancer. In specific...
US20110250131 Antigens Associated with Endometriosis, Psoriatic Arthritis and Psoriasis  
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, and/or for use in delivery to the...
US20110135568 THICKENED BEVERAGES FOR DYSPHAGIA  
The present invention relates to thickened beverage compositions. More particularly the invention relates to beverage compositions thickened for the management of dysphagia. More particularly this...
US20130302244 METHOD OF PREPARING IODINE SEED FOR TREATING EYE DISEASE OR CANCER, AND IODINE SEED PREPARED THEREBY  
The present invention provides a technique for adsorbing I-125 on a support for treating cancer and a method of preparing an I-125 seed using the same. Since a method of preparing iodine according...
US20140161719 PORPHYRIN MODIFIED TELODENDRIMERS  
The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include...
US20120251439 Antigens Associated with Inflammatory Bowel Disease Including Ulcerative Colitis  
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of inflammatory bowel disease such as ulcerative colitis...
US20120052003 MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY  
Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by...
US20110064650 MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY  
Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by...
US20140248211 METHOD OF TREATING CANCER  
The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and...
US20140227172 DIAGNOSIS AND TREATMENT OF PROSTATE CANCER  
The methods of the present disclosure are directed toward methods of diagnosis and treatment of cancer in a subject. The present disclosure provides methods of diagnosing abnormal cells in a...
US20130266508 THERMOSENSITIVE HYDROGEL FOR COATING RADIOISOTOPE AND CHEMOTHERAPEUTIC AGENT TO TREAT CANCER AND METHOD FOR PREPARING THE SAME  
A thermosensitive hydrogel for coating radioisotopes and chemotherapeutic agents to treat cancer and a method for preparing the same are revealed. The anticancer drugs such as radiopharmaceuticals...
US20120128580 PRESELECTION OF SUBJECTS FOR THERAPEUTIC TREATMENT WITH ELESCLOMOL BASED ON HYPOXIC STATUS  
The present invention provides methods for the preselection of a subject for therapeutic treatment with elesclomol based on modulated levels of hypoxia in the subject. In one embodiment, the...
US20100310451 ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A)  
The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a...
US20110044895 METHODS AND COMPOSITIONS FOR REDUCING STEMNESS IN ONCOGENESIS  
The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The...
US20140271457 Dual Specific Binding Proteins Directed Against TNF  
Engineered multivalent and multispecific binding proteins that bind TNFα and IL-13, TNFα and PGE2, or TNFα and NGF are provided, along with methods of making and uses in the prevention, diagnosis,...
US20140199232 Targeted Therapeutic Nanoparticles  
Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides...
US20140056807 LARGE ONCOSOMES IN HUMAN TUMORS AND IN CIRCULATION IN PATIENTS WITH CANCER  
The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes in a subject in need thereof.
US20110085968 ARTICLES COMPRISING NANO-MATERIALS FOR GEOMETRY-GUIDED STEM CELL DIFFERENTIATION AND ENHANCED BONE GROWTH  
The present invention provides articles of manufacture comprising biocompatible nanostructures comprising significantly increased surface area for, e.g., organ, tissue and/or cell growth, e.g.,...