IODININ AS AN ANTI-HYPERTENSIVE AGENT
United States Patent 3764679
A method of reducing blood pressure in hypertensive patients by administering a therapeutically effective amount of iodinin to said patients.
Inventors:
Jones, Peter Hadley (Lake Forest, IL)
Somani, Pitambar (Village of Libertyville, IL)
Somani, Pitambar (Village of Libertyville, IL)
Application Number:
05/236179
Publication Date:
10/09/1973
Filing Date:
03/20/1972
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Export Citation:
Assignee:
Abbott Laboratories (North Chicago, IL)
Primary Class:
International Classes:
A61K31/495; A61K27/00
Field of Search:
424/250
Other References:
Chemical Abstracts 71: 79596 W (1969)..
Primary Examiner:
Goldberg, Jerome D.
Claims:
We claim
1. A method of lowering blood pressure in a hypertensive patient comprising administering a therapeutically effective amount of iodinin to said patient.
1. A method of lowering blood pressure in a hypertensive patient comprising administering a therapeutically effective amount of iodinin to said patient.
Description:
DETAILED DESCRIPTION OF THE INVENTION
This invention relates to a method of reducing blood pressure in hypertensive patients using iodinin as the anti-hypertensive agent.
Iodinin is represented by the formula ##SPC1##
The compound can be prepared according to the method described by U.S. Pat. No. 3,432,505.
Iodinin has previously been reported to be an antibacterial agent (see U.S. Pat. No. 3,432,505). We have unexpectedly found that iodinin is an effective anti-hypertensive agent.
The anti-hypertensive activity of iodinin was first established in the spontaneously hypertensive rat procedure, Tabei et al. Clin. Pharmac. and Therap., 11 (2): 269-274, (1970).
Iodinin is effective as an anti-hypertensive agent at dosages of from approximately 0.1 to approximately 300 mg./kg. of body weight daily and is administered to hypertensive patients at such dosages, preferably by the oral route in divided dosages i.e., 3 to 4 times daily. It may also be co-administered with, for example, diuretics or tranquilizers.
The oral LD 50 of iodinin is greater than 1 gram/kg. Therefore, a good therapeutic index of safety is present.
While iodinin can be administered alone, that is, as a sole component of a filled capsule, it is preferred to formulate the compound in various dosage forms for oral or parenteral administration, such as tablets, syrups, sterile aqueous or non-aqueous suspensions and the like. The oral dosage forms are prepared by the methods well known in the art, as are the parenteral and generally include a pharmaceutically acceptable carrier or diluent.
This invention relates to a method of reducing blood pressure in hypertensive patients using iodinin as the anti-hypertensive agent.
Iodinin is represented by the formula ##SPC1##
The compound can be prepared according to the method described by U.S. Pat. No. 3,432,505.
Iodinin has previously been reported to be an antibacterial agent (see U.S. Pat. No. 3,432,505). We have unexpectedly found that iodinin is an effective anti-hypertensive agent.
The anti-hypertensive activity of iodinin was first established in the spontaneously hypertensive rat procedure, Tabei et al. Clin. Pharmac. and Therap., 11 (2): 269-274, (1970).
Iodinin is effective as an anti-hypertensive agent at dosages of from approximately 0.1 to approximately 300 mg./kg. of body weight daily and is administered to hypertensive patients at such dosages, preferably by the oral route in divided dosages i.e., 3 to 4 times daily. It may also be co-administered with, for example, diuretics or tranquilizers.
The oral LD 50 of iodinin is greater than 1 gram/kg. Therefore, a good therapeutic index of safety is present.
While iodinin can be administered alone, that is, as a sole component of a filled capsule, it is preferred to formulate the compound in various dosage forms for oral or parenteral administration, such as tablets, syrups, sterile aqueous or non-aqueous suspensions and the like. The oral dosage forms are prepared by the methods well known in the art, as are the parenteral and generally include a pharmaceutically acceptable carrier or diluent.